CUSIP: 000899104 | NYSE | Healthcare · Biotechnology | Mid Cap | 844 institutional holders
5%+ stakes reported outside the quarterly cycle. A 13D is due within five business days of the event below, so these figures lead the holders table until the filer's next 13F catches up to them.
| Holder | Shares | % of Class | Change | Event Date | vs 13F |
|---|---|---|---|---|---|
| 13GState Street Corporation with SSgA Funds Management, Inc. | 17,116,022 | 7.4% | New 5%+ stake | Jun 30, 2026 | No 13F filer matched |
| Style | Turnover | Location | Filed | ||||
|---|---|---|---|---|---|---|---|
| 3,544,600 | $35.6M | 0.0% | Index | Low | Austin, TX | 2026-11-04 | |
| 1,877,688 | $18.8M | 0.0% | Core | Low | Des Moines, IA | 2026-11-02 | |
| 361,308 | $3.6M | 0.7% | Core | Low | Hunt Valley, MD | 2026-10-23 | |
| 265,689 | $2.7M | 0.6% | Value | Medium | Lake Oswego, OR | 2026-10-29 | |
| 261,234 | $2.6M | 0.0% | Core | Medium | New York, NY | 2026-11-04 | |
| 189,577 | $1.9M | 0.0% | Core | Very Low | Albany, NY | 2026-10-22 | |
| 184,617 | $1.9M | 0.0% | Index | Very Low | Overland Park, KS | 2026-11-02 | |
| 156,500 | $1.6M | 0.0% | Core | Medium | Columbus, OH | 2026-10-30 | |
| 151,840 | $1.5M | 0.0% | Value | Very High | Hong Kong, South Korea | 2026-10-16 | |
| 95,400 | $956.9K | 0.0% | Index | Low | Baton Rouge, LA | 2026-10-20 | |
| 93,132 | $933.0K | 0.0% | Core | Very Low | Juneau, AK | 2026-10-15 | |
| 88,283 | $885.5K | 0.0% | Growth | Medium | Alexandria, VA | 2026-10-27 | |
| 83,837 | $840.9K | 0.0% | Core | Medium | Richmond, VA | 2026-10-28 | |
| 81,607 | $818.5K | 0.0% | Value | Very High | Greenwich, CT | 2026-11-02 | |
| 77,152 | $773.8K | 0.0% | Growth | Low | Bethesda, MD | 2026-10-29 | |
| 71,110 | $713.2K | 0.0% | Core | Low | Trenton, NJ | 2026-11-05 | |
| 68,227 | $684.3K | 0.0% | Core | Very High | Chicago, IL | 2026-11-04 | |
| 63,495 | $636.9K | 0.0% | Yield | Low | Denver, CO | 2026-11-03 | |
| 63,222 | $634.1K | 0.0% | GARP | High | Meridian, ID | 2026-10-22 | |
| 62,990 | $631.8K | 0.0% | Growth | Very Low | Seattle, WA | 2026-10-27 | |
| 62,053 | $622.4K | 0.0% | Index | Very Low | Phoenix, AZ | 2026-11-03 | |
| 58,364 | $585.4K | 0.0% | Index | Very Low | Bloomfield Hills, MI | 2026-10-22 | |
| 58,246 | $584.0K | 0.0% | Core | Very Low | New York, NY | 2026-10-23 | |
| 57,017 | $424.2K | 0.0% | Core | Low | Plymouth, MN | 2026-10-13 | |
| 54,480 | $546.4K | 0.0% | Core | Low | New York, NY | 2026-10-26 | |
| 52,774 | $529.3K | 0.0% | Core | Low | Harrisburg, PA | 2026-11-03 | |
| 50,299 | $504.5K | 0.0% | Index | Very Low | Tigard, OR | 2026-10-30 | |
| 48,056 | $482.0K | 0.0% | Growth | Medium | Helsinki, Hungary | 2026-11-05 | |
| 43,500 | $436.3K | 0.3% | Momentum | Medium | Forest, VA | 2026-10-28 | |
| 41,036 | $411.6K | 0.0% | Growth | Medium | Carouge, Switzerland | 2026-11-03 | |
| 40,868 | $407.0K | 0.0% | Growth | Medium | Shanghai, France | 2026-10-28 | |
| 39,323 | $394.4K | 0.0% | Growth | Low | Bethesda, MD | 2026-10-29 | |
| 37,628 | $377.4K | 0.3% | ETF | Medium | Troy, MI | 2026-10-08 | |
| 32,699 | $328.0K | 0.0% | Growth | Low | Los Angeles, CA | 2026-11-04 | |
| 32,087 | $318.6K | 0.0% | Core | Medium | Charlotte, NC | 2026-11-04 | |
| 31,623 | $317.2K | 0.0% | Core | Low | Zurich, Switzerland | 2026-11-03 | |
| 29,951 | $300.0K | 0.1% | Core | Medium | Bountiful, UT | 2026-10-28 | |
| 28,940 | $290.3K | 0.1% | ETF | Very Low | Sugar Land, TX | 2026-10-21 | |
| 25,558 | $256.3K | 0.0% | Index | Low | New York, NY | 2026-10-23 | |
| 23,300 | $233.7K | 0.0% | ETF | Low | Waltham, MA | 2026-11-02 | |
| 23,041 | $231.1K | 0.0% | Core | Medium | Baton Rouge, LA | 2026-10-19 | |
| 21,906 | $219.7K | 0.0% | Index | Very Low | Philadelphia, PA | 2026-11-03 | |
| 17,700 | $177.5K | 0.0% | Deep Value | Low | Modesto, CA | 2026-10-30 | |
| 17,427 | $174.8K | 0.0% | Core | Medium | Raleigh, NC | 2026-10-14 | |
| 16,719 | $167.7K | 0.0% | GARP | Medium | Houston, TX | 2026-11-02 | |
| 16,644 | $166.9K | 0.0% | Value | High | Cheyenne, WY | 2026-10-28 | |
| 16,300 | $163.5K | 0.1% | ETF | Medium | Sister Bay, WI | 2026-10-13 | |
| 15,952 | $164.8K | 0.0% | Growth | Low | Plymouth, MN | 2026-10-13 | |
| 15,575 | $156.2K | 0.0% | Agg Growth | Low | Tokyo, Mexico | 2026-10-22 | |
| 15,288 | $153.3K | 0.0% | Growth | Medium | Provo, UT | 2026-10-20 | |
| 14,963 | $149.0K | 0.0% | Core | Medium | London, United Kingdom | 2026-11-04 | |
| 14,319 | $144.0K | 0.0% | ETF | Low | Fairfield, IA | 2026-11-02 | |
| 13,038 | $130.8K | 0.0% | Core | Low | New York, NY | 2026-11-03 | |
| 12,744 | $127.8K | 0.1% | Growth | High | Plano, TX | 2026-10-21 | |
| 12,330 | $123.7K | 0.0% | Index | Very Low | Atlanta, GA | 2026-10-23 | |
| 12,139 | $121.8K | 0.0% | GARP | Medium | Bellevue, WA | 2026-10-23 | |
| 11,805 | $118.4K | 0.0% | Core | Low | Westborough, MA | 2026-10-29 | |
| 11,446 | $114.8K | 0.0% | Growth | Low | Seoul, Malaysia | 2026-11-03 | |
| 11,229 | $119.9K | 0.0% | GARP | Low | Chicago, IL | 2026-10-27 | |
| 10,639 | $106.7K | 0.1% | Core | High | San Juan, PR | 2026-11-03 | |
| 10,214 | $102.4K | 0.0% | Index | Very Low | Cincinnati, OH | 2026-10-22 | |
| 10,000 | $100.3K | 0.0% | ETF | Medium | Libertyville, IL | 2026-10-09 | |
| 7,791 | $78.0K | 0.0% | Core | Medium | Brussels, Czech Republic | 2026-10-22 | |
| 7,679 | $77.0K | 0.0% | GARP | Medium | Charlotte, NC | 2026-10-22 | |
| 6,500 | $65.2K | 0.0% | ETF | Low | Southfied, MI | 2026-10-26 | |
| 6,119 | $61.4K | 0.0% | Index | Very Low | Foster City, CA | 2026-10-08 | |
| 5,757 | $57.7K | 0.0% | Index | Very Low | St. Louis, MO | 2026-10-20 | |
| 5,721 | $57.4K | 0.0% | GARP | Low | Mansfield, OH | 2026-10-27 | |
| 5,490 | $55.1K | 0.0% | Agg Growth | Medium | Guangzhou, France | 2026-10-26 | |
| 3,896 | $39.1K | 0.0% | Index | Low | Atlanta, GA | 2026-10-23 | |
| 3,181 | $31.9K | 0.0% | Index | Low | San Francisco, CA | 2026-10-08 | |
| 2,941 | $29.8K | 0.0% | Core | Low | Stamford, CT | 2026-10-22 | |
| 2,773 | $27.8K | 0.0% | ETF | Very Low | Richmond, VA | 2026-10-29 | |
| 2,569 | $26.0K | 0.0% | ETF | Low | Lake Forest, IL | 2026-10-23 | |
| 2,447 | $24.5K | 0.0% | Core | Medium | Birmingham, AL | 2026-11-04 | |
| 1,696 | $17.0K | 0.0% | ETF | Very Low | Sylvania, OH | 2026-10-26 | |
| 1,162 | $11.7K | 0.0% | Index | Very Low | Tokyo, Mexico | 2026-11-05 | |
| 1,100 | $11.0K | 0.0% | Value | High | Chicago, IL | 2026-10-22 | |
| 1,000 | $10.0K | 0.0% | Agg Growth | Medium | Boca Raton, FL | 2026-10-15 | |
| 1,000 | $10.0K | 0.0% | Growth | Low | Morristown, NJ | 2026-10-13 | |
| 903 | $9.1K | 0.0% | Core | Low | Wilmington, DE | 2026-10-23 | |
| 812 | $8.1K | 0.0% | ETF | Very Low | Gap, PA | 2026-11-04 | |
| 806 | $8.1K | 0.0% | Index | Low | San Francisco, CA | 2026-11-03 | |
| 643 | $6.4K | 0.0% | ETF | Low | Fort Lauderdale, FL | 2026-10-30 | |
| 592 | $5.9K | 0.0% | Growth | Very High | Hong Kong, South Korea | 2026-10-29 | |
| 572 | $5.7K | 0.0% | Value | Medium | Rancho Santa Fe, CA | 2026-10-14 | |
| 516 | $5.2K | 0.0% | Growth | Low | Saratoga Springs, NY | 2026-10-14 | |
| 479 | $4.8K | 0.0% | ETF | Medium | Encinitas, CA | 2026-10-21 | |
| 450 | $4.5K | 0.0% | Index | Low | Greenwood Village, CO | 2026-10-20 | |
| 425 | $4.3K | 0.0% | Core | Very Low | Saint Louis, MO | 2026-10-27 | |
| 415 | $4.2K | 0.0% | Growth | Very Low | Beverly Hills, CA | 2026-10-27 | |
| 338 | $3.4K | 0.0% | Core | Low | Springfield, MA | 2026-10-05 | |
| 259 | $2.6K | 0.0% | ETF | Medium | Akron, OH | 2026-10-13 | |
| 237 | $2.4K | 0.0% | Core | Very Low | Lincoln, NE | 2026-10-22 | |
| 210 | $2.1K | 0.0% | ETF | Low | Dallas, TX | 2026-11-03 | |
| 119 | $1.2K | 0.0% | Growth | N/A | Kansas City, MO | 2026-10-19 | |
| 112 | $1.1K | 0.0% | GARP | Low | Phoenix, AZ | 2026-10-02 | |
| 100 | $1.0K | 0.0% | Core | Medium | Birmingham, AL | 2026-10-26 | |
| 57 | $572 | 0.0% | Growth | Low | Tampa, FL | 2026-10-16 | |
| 51 | $512 | 0.0% | ETF | Low | Concord, CA | 2026-10-21 | |
| 50 | $502 | 0.0% | ETF | Low | Bethlehem, PA | 2026-10-23 | |
| 45 | $452 | 0.0% | Growth | Low | Denver, CO | 2026-10-09 | |
| 44 | $442 | 0.0% | ETF | Very Low | Orinda, CA | 2026-10-29 | |
| 40 | $401 | 0.0% | ETF | Very Low | Lake Oswego, OR | 2026-10-15 | |
| 37 | $372 | 0.0% | ETF | Very Low | Hermitage, PA | 2026-11-03 | |
| 24 | $241 | 0.0% | ETF | Medium | Scottsdale, AZ | 2026-10-14 | |
| 22 | $259 | 0.0% | ETF | Low | Herndon, VA | 2026-10-30 | |
| 21 | $211 | 0.0% | ETF | Low | San Diego, CA | 2026-10-28 | |
| 19 | $191 | 0.0% | ETF | Low | Hunt Valley, MD | 2026-10-23 | |
| 16 | $160 | 0.0% | ETF | Very Low | Manhattan, KS | 2026-10-09 | |
| 13 | $130 | 0.0% | Core | Low | Jacksonville, FL | 2026-10-08 | |
| 12 | $120 | 0.0% | ETF | Very Low | Boca Raton, FL | 2026-10-15 | |
| 10 | $100 | 0.0% | ETF | Medium | Southfield, MI | 2026-10-08 | |
| 10 | $101 | 0.0% | ETF | Very Low | Franklin, TN | 2026-10-26 | |
| 5 | $0 | 0.0% | ETF | Low | Shaker Heights, OH | 2026-10-27 | |
| 4 | $40 | 0.0% | ETF | Very Low | Mesa, AZ | 2026-10-27 | |
| 4 | $41 | 0.0% | ETF | Low | Beaver, PA | 2026-10-16 | |
| 2 | $20 | 0.0% | ETF | Medium | Hunt Valley, MD | 2026-11-03 | |
| 1 | $11 | 0.0% | ETF | Very Low | Chester, MD | 2026-10-15 | |
| 1 | $10 | 0.0% | ETF | Low | Newport Beach, CA | 2026-10-16 |