Spyre Therapeutics Inc (SYRE)

CUSIP: 00773J202 | NYSE | Healthcare · Biotechnology | Mid Cap | 387 institutional holders

Compare Detailed Historical Funds Options 13D/13G Peers Targeting Trading Summary Profile

Beneficial Ownership — 13D / 13G

5%+ stakes reported outside the quarterly cycle. A 13D is due within five business days of the event below, so these figures lead the holders table until the filer's next 13F catches up to them.

Holder	Shares	% of Class	Change	Event Date	vs 13F
13D/AKiselak Tomas with Fairmount Funds Management LLC, Fairmount Healthcare Fund II L.P.	10,185,961	10.0%	+518,760	Oct 7, 2026	No 13F filer matched
13GParadigm BioCapital Advisors LP with Paradigm BioCapital International Fund Ltd.

Institutional Holders — Q3 2026

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Assenagon Asset Management S.A.599,224

0.1% of portfolio$53.3M

Pictet Asset Management Holding SA479,135

0.0% of portfolio$42.7M

Candriam S.C.A.448,570

0.2% of portfolio$40.1M

Bank of New York Mellon Corp261,592

0.0% of portfolio$23.3M

SEB Asset Management AB89,950

0.0% of portfolio$8.0M

Dimensional Fund Advisors LP72,290

0.0% of portfolio$6.4M

Principal Financial Group Inc63,936

0.0% of portfolio$5.7M

Moody Aldrich Partners LLC44,195

0.8% of portfolio$3.9M

Citigroup Inc41,205

0.0% of portfolio$3.7M

Creative Planning29,618

0.0% of portfolio$2.6M

Profund Advisors LLC26,406

0.1% of portfolio$2.4M

State of New Jersey Common Pension Fund D19,783

0.0% of portfolio$1.8M

Arizona State Retirement System17,268

0.0% of portfolio$1.5M

China Universal Asset Management Co., Ltd.16,088

0.1% of portfolio$1.4M

Strs Ohio13,500

0.0% of portfolio$1.2M

Virginia Retirement Systems ET Al13,050

0.0% of portfolio$1.2M

ProShare Advisors LLC12,653

0.0% of portfolio$1.1M

New York Life Investment Management LLC11,660

0.0% of portfolio$1.0M

B. Metzler seel. Sohn & Co. AG10,852

0.0% of portfolio$966.2K

Calamos Advisors LLC7,410

0.0% of portfolio$659.7K

Xponance LLC7,251

0.0% of portfolio$645.6K

Assetmark, Inc7,232

0.0% of portfolio$643.9K

AlphaCentric Advisors LLC6,956

0.5% of portfolio$619.3K

Allspring Global Investments Holdings, LLC6,355

0.0% of portfolio$571.5K

High Net Worth Advisory Group LLC6,000

0.1% of portfolio$534.2K

Inspire Investing, LLC4,544

0.0% of portfolio$404.6K

Mirae Asset Global Investments Co., Ltd.4,506

0.0% of portfolio$401.2K

Atria Investments, Inc4,098

0.0% of portfolio$364.8K

Swiss Life Asset Management Ltd3,870

0.0% of portfolio$344.5K

Wealth Enhancement Advisory Services, LLC3,227

0.0% of portfolio$257.8K

State of Wyoming3,202

0.0% of portfolio$285.1K

Nisa Investment Advisors, LLC2,918

0.0% of portfolio$259.8K

Oppenheimer Asset Management Inc.2,806

0.0% of portfolio$249.8K

Sterling Capital Management LLC2,522

0.0% of portfolio$224.5K

CIBC Asset Management Inc2,429

0.0% of portfolio$216.3K

Elevation Point Wealth Partners, LLC2,251

0.0% of portfolio$200.2K

GF Fund Management Co. Ltd.2,216

0.0% of portfolio$197.3K

KBC Group NV1,796

0.0% of portfolio$160.0K

Parallel Advisors, LLC1,560

0.0% of portfolio$138.9K

DekaBank Deutsche Girozentrale1,389

0.0% of portfolio$125

Farther Finance Advisors, LLC1,110

0.0% of portfolio$98.8K

SBI Securities Co., Ltd.1,026

0.0% of portfolio$91.3K

EverSource Wealth Advisors, LLC954

0.0% of portfolio$84.9K

Gamma Investing LLC825

0.0% of portfolio$73.5K

IFP Advisors, Inc802

0.0% of portfolio$71.4K

Harbor Investment Advisory, LLC674

0.0% of portfolio$60.0K

J.Safra Asset Management Corp466

0.0% of portfolio$41.5K

Bayforest Capital Ltd226

0.0% of portfolio$20.1K

Leonteq Securities AG101

0.0% of portfolio$9.0K

Caitong International Asset Management Co., Ltd86

0.0% of portfolio$7.7K

Covestor Ltd84

0.0% of portfolio$7

Parkside Financial Bank & Trust80

0.0% of portfolio$7.1K

Signaturefd, LLC74

0.0% of portfolio$6.6K

Larson Financial Group LLC57

0.0% of portfolio$5.1K

Redwood Park Advisors LLC42

0.0% of portfolio$3.7K

Cullen T Bankers, Inc.30

0.0% of portfolio$2.7K

Mather Group, Llc.29

0.0% of portfolio$2.6K

Private Trust Co NA26

0.0% of portfolio$2.3K

Physician Wealth Advisors, Inc.26

0.0% of portfolio$2.3K

Silver Grove Financial Group, Inc.25

0.0% of portfolio$2.2K

Cape Investment Advisory, Inc.21

0.0% of portfolio$1.9K

Bare Financial Services, Inc16

0.0% of portfolio$1.4K

Burk Holdings LLC8

0.0% of portfolio$712

Hughes Financial Services, LLC6

0.0% of portfolio$594

Ascentis Wealth Management, LLC3

0.0% of portfolio$267

Essential Partners LLC2

0.0% of portfolio$178

Root Financial Partners, LLC1

0.0% of portfolio$89

				Style	Turnover	Location	Filed
Assenagon Asset Management S.A.	599,224	$53.3M	0.1%	Growth	High	Senningerberg, Netherlands	2026-10-15
Pictet Asset Management Holding SA	479,135	$42.7M	0.0%	Growth	Medium	Carouge, Switzerland	2026-11-03
Candriam S.C.A.	448,570	$40.1M	0.2%	Growth	Medium	Strassen, Netherlands	2026-11-03
Bank of New York Mellon Corp	261,592	$23.3M	0.0%	Core	Low	New York, NY	2026-11-05
SEB Asset Management AB	89,950	$8.0M	0.0%	Core	N/A	Stockholm, Sweden	2026-11-04
Dimensional Fund Advisors LP	72,290	$6.4M	0.0%	Index	Low	Austin, TX	2026-11-04
Principal Financial Group Inc	63,936	$5.7M	0.0%	Core	Low	Des Moines, IA	2026-11-02
Moody Aldrich Partners LLC	44,195	$3.9M	0.8%	Value	High	Marblehead, MA	2026-10-27
Citigroup Inc	41,205	$3.7M	0.0%	Core	Medium	New York, NY	2026-11-04
Creative Planning	29,618	$2.6M	0.0%	Index	Very Low	Overland Park, KS	2026-11-02
Profund Advisors LLC	26,406	$2.4M	0.1%	Growth	Low	Bethesda, MD	2026-10-29
State of New Jersey Common Pension Fund D	19,783	$1.8M	0.0%	Core	Low	Trenton, NJ	2026-11-05
Arizona State Retirement System	17,268	$1.5M	0.0%	Index	Very Low	Phoenix, AZ	2026-11-03
China Universal Asset Management Co., Ltd.	16,088	$1.4M	0.1%	Growth	Medium	Shanghai, France	2026-10-28
Strs Ohio	13,500	$1.2M	0.0%	Core	Medium	Columbus, OH	2026-10-30
Virginia Retirement Systems ET Al	13,050	$1.2M	0.0%	Core	Medium	Richmond, VA	2026-10-28
ProShare Advisors LLC	12,653	$1.1M	0.0%	Growth	Low	Bethesda, MD	2026-10-29
New York Life Investment Management LLC	11,660	$1.0M	0.0%	Growth	Low	New York, NY	2026-11-04
B. Metzler seel. Sohn & Co. AG	10,852	$966.2K	0.0%	Growth	Medium	Frankfurt, Hong Kong	2026-10-30
Calamos Advisors LLC	7,410	$659.7K	0.0%	Growth	Medium	Naperville, IL	2026-11-02
Xponance LLC	7,251	$645.6K	0.0%	Index	Very Low	Philadelphia, PA	2026-11-03
Assetmark, Inc	7,232	$643.9K	0.0%	ETF	Low	Concord, CA	2026-10-21
AlphaCentric Advisors LLC	6,956	$619.3K	0.5%	Core	High	San Juan, PR	2026-11-03
Allspring Global Investments Holdings, LLC	6,355	$571.5K	0.0%	Core	Medium	Charlotte, NC	2026-11-04
High Net Worth Advisory Group LLC	6,000	$534.2K	0.1%	ETF	Very Low	Naples, FL	2026-10-26
Inspire Investing, LLC	4,544	$404.6K	0.0%	GARP	High	Meridian, ID	2026-10-22
Mirae Asset Global Investments Co., Ltd.	4,506	$401.2K	0.0%	Growth	Low	Seoul, Malaysia	2026-11-03
Atria Investments, Inc	4,098	$364.8K	0.0%	Core	Medium	Charlotte, NC	2026-10-15
Swiss Life Asset Management Ltd	3,870	$344.5K	0.0%	Core	Low	Zurich, Switzerland	2026-11-03
Wealth Enhancement Advisory Services, LLC	3,227	$257.8K	0.0%	Core	Low	Plymouth, MN	2026-10-13
State of Wyoming	3,202	$285.1K	0.0%	Value	High	Cheyenne, WY	2026-10-28
Nisa Investment Advisors, LLC	2,918	$259.8K	0.0%	Index	Very Low	St. Louis, MO	2026-10-20
Oppenheimer Asset Management Inc.	2,806	$249.8K	0.0%	Core	Medium	New York, NY	2026-10-27
Sterling Capital Management LLC	2,522	$224.5K	0.0%	GARP	Medium	Charlotte, NC	2026-10-22
CIBC Asset Management Inc	2,429	$216.3K	0.0%	GARP	Low	Toronto, South Africa	2026-11-05
Elevation Point Wealth Partners, LLC	2,251	$200.2K	0.0%	Core	High	Denver, CO	2026-11-05
GF Fund Management Co. Ltd.	2,216	$197.3K	0.0%	Agg Growth	Medium	Guangzhou, France	2026-10-26
KBC Group NV	1,796	$160.0K	0.0%	Core	Medium	Brussels, Czech Republic	2026-10-22
Parallel Advisors, LLC	1,560	$138.9K	0.0%	Index	Low	San Francisco, CA	2026-11-03
DekaBank Deutsche Girozentrale	1,389	$125	0.0%	Core	Low	Frankfurt, Hong Kong	2026-10-27
Farther Finance Advisors, LLC	1,110	$98.8K	0.0%	Index	Low	San Francisco, CA	2026-10-08
SBI Securities Co., Ltd.	1,026	$91.3K	0.0%	Agg Growth	Low	Tokyo, Mexico	2026-10-22
EverSource Wealth Advisors, LLC	954	$84.9K	0.0%	Core	Medium	Birmingham, AL	2026-11-04
Gamma Investing LLC	825	$73.5K	0.0%	Index	Very Low	Foster City, CA	2026-10-08
IFP Advisors, Inc	802	$71.4K	0.0%	Growth	Low	Tampa, FL	2026-10-16
Harbor Investment Advisory, LLC	674	$60.0K	0.0%	Growth	Low	Lutherville, MD	2026-10-13
J.Safra Asset Management Corp	466	$41.5K	0.0%	ETF	Low	New York, NY	2026-11-03
Bayforest Capital Ltd	226	$20.1K	0.0%	Deep Value	Very High	London, United Kingdom	2026-11-03
Leonteq Securities AG	101	$9.0K	0.0%	Core	High	Zurich, Switzerland	2026-10-29
Caitong International Asset Management Co., Ltd	86	$7.7K	0.0%	Growth	Very High	Hong Kong, South Korea	2026-10-29
Covestor Ltd	84	$7	0.0%	Value	High	London, United Kingdom	2026-10-30
Parkside Financial Bank & Trust	80	$7.1K	0.0%	Core	Very Low	Saint Louis, MO	2026-10-27
Signaturefd, LLC	74	$6.6K	0.0%	Index	Low	Atlanta, GA	2026-10-23
Larson Financial Group LLC	57	$5.1K	0.0%	Growth	Low	St Louis, MO	2026-11-05
Redwood Park Advisors LLC	42	$3.7K	0.0%	ETF	Very Low	Redwood City, CA	2026-11-02
Cullen T Bankers, Inc.	30	$2.7K	0.0%	Growth	Low	San Antonio, TX	2026-10-28
Mather Group, Llc.	29	$2.6K	0.0%	ETF	Medium	Chicago, IL	2026-10-14
Private Trust Co NA	26	$2.3K	0.0%	Core	Low	Cleveland, OH	2026-10-20
Physician Wealth Advisors, Inc.	26	$2.3K	0.0%	ETF	Medium	Midvale, UT	2026-10-20
Silver Grove Financial Group, Inc.	25	$2.2K	0.0%	Core	Medium	Orchard Park, NY	2026-11-05
Cape Investment Advisory, Inc.	21	$1.9K	0.0%	ETF	Low	Mcdonough, GA	2026-10-13
Bare Financial Services, Inc	16	$1.4K	0.0%	ETF	Very Low	Gap, PA	2026-11-04
Burk Holdings LLC	8	$712	0.0%	ETF	Very Low	Tulsa, OK	2026-11-05
Hughes Financial Services, LLC	6	$594	0.0%	ETF	Low	Herndon, VA	2026-10-30
Ascentis Wealth Management, LLC	3	$267	0.0%	Agg Growth	Low	Dallas, TX	2026-11-03
Essential Partners LLC	2	$178	0.0%	Value	Medium	Rancho Santa Fe, CA	2026-10-14
Root Financial Partners, LLC	1	$89	0.0%	ETF	Medium	Encinitas, CA	2026-10-21