CUSIP: 528872302 | NYSE | Healthcare · Biotechnology | Small Cap | 596 institutional holders
5%+ stakes reported outside the quarterly cycle. A 13D is due within five business days of the event below, so these figures lead the holders table until the filer's next 13F catches up to them.
| Holder | Shares | % of Class | Change | Event Date | vs 13F |
|---|---|---|---|---|---|
| 13G/AFMR LLC | 66,743,390 | 15.0% | +14,961,345 | Sep 30, 2026 | 92d ahead of 13F (51,782,045 sh) · +14,961,345 |
| 13D/AArtal International Management S.A. with Raymond Debbane, Invus Global Management, LLC, Invus, L.P., +8 more | 175,156,062 | 39.4% | +20,421,735 | Apr 30, 2026 | No 13F filer matched |
| 13D/AMr. Amaury Wittouck with Mr. Raymond Debbane, Invus, L.P., Ulys, L.L.C. | 154,734,327 | 36.2% | New 5%+ stake | Jan 29, 2026 | No 13F filer matched |
| Style | Turnover | Location | Filed | ||||
|---|---|---|---|---|---|---|---|
| 535,048 | $1.0M | 0.0% | Core | Low | New York, NY | 2026-11-05 | |
| 480,000 | $900.0K | 0.0% | Growth | Medium | 1204 Geneva, Switzerland | 2026-11-04 | |
| 340,479 | $638.4K | 0.0% | Growth | Low | Bethesda, MD | 2026-10-29 | |
| 217,452 | $407.7K | 0.3% | Core | N/A | West Chester, OH | 2026-10-13 | |
| 154,665 | $290.0K | 0.0% | Core | Medium | New York, NY | 2026-11-04 | |
| 71,428 | $133.9K | 0.0% | Core | High | Austin, TX | 2026-11-03 | |
| 68,142 | $127.8K | 0.0% | Core | Low | Trenton, NJ | 2026-11-05 | |
| 62,666 | $117.5K | 0.0% | ETF | Low | Jenison, MI | 2026-10-23 | |
| 59,532 | $111.6K | 0.0% | Index | Very Low | Phoenix, AZ | 2026-11-03 | |
| 35,300 | $66.2K | 0.0% | Core | Medium | Richmond, VA | 2026-10-28 | |
| 29,921 | $56.1K | 0.0% | Core | Very High | Chicago, IL | 2026-11-04 | |
| 28,615 | $53.7K | 0.0% | Core | Low | New York, NY | 2026-10-20 | |
| 28,509 | $53.5K | 0.0% | Growth | Low | Bethesda, MD | 2026-10-29 | |
| 26,226 | $49.2K | 0.0% | Core | Low | Des Moines, IA | 2026-11-02 | |
| 25,326 | $47.5K | 0.0% | Growth | Very High | Hong Kong, South Korea | 2026-10-29 | |
| 23,242 | $43.6K | 0.0% | Index | Very Low | Overland Park, KS | 2026-11-02 | |
| 22,210 | $41.6K | 0.0% | Index | Very Low | Philadelphia, PA | 2026-11-03 | |
| 21,835 | $40.9K | 0.0% | Growth | Medium | Carouge, Switzerland | 2026-11-03 | |
| 20,000 | $38 | 0.0% | Core | Low | Pasadena, CA | 2026-10-22 | |
| 20,000 | $37.5K | 0.0% | Growth | Medium | Bend, OR | 2026-10-28 | |
| 15,012 | $28.1K | 0.0% | Value | High | Cheyenne, WY | 2026-10-28 | |
| 14,000 | $26.3K | 0.0% | Core | Low | Charlotte, NC | 2026-10-30 | |
| 13,102 | $24.6K | 0.0% | GARP | Low | Toronto, South Africa | 2026-11-05 | |
| 11,765 | $20.7K | 0.0% | Core | Low | Plymouth, MN | 2026-10-13 | |
| 11,378 | $21.3K | 0.0% | Growth | Low | Mount Pleasant, SC | 2026-10-23 | |
| 10,000 | $18.8K | 0.0% | Core | Low | Norwich, NY | 2026-10-21 | |
| 7,491 | $14.0K | 0.0% | GARP | Medium | Charlotte, NC | 2026-10-22 | |
| 4,208 | $7.9K | 0.0% | Agg Growth | Low | Tokyo, Mexico | 2026-10-22 | |
| 3,646 | $6.8K | 0.0% | Index | Very Low | St. Louis, MO | 2026-10-20 | |
| 1,412 | $2.6K | 0.0% | ETF | Medium | Midvale, UT | 2026-10-20 | |
| 1,115 | $2 | 0.0% | ETF | Low | The Woodlands, TX | 2026-11-04 | |
| 1,000 | $1.9K | 0.0% | ETF | Very Low | Mclean, VA | 2026-10-27 | |
| 957 | $1.8K | 0.0% | Core | Low | Springfield, MA | 2026-10-05 | |
| 706 | $1.3K | 0.0% | ETF | Medium | Scottsdale, AZ | 2026-10-14 | |
| 505 | $945 | 0.0% | Core | Very Low | Saint Louis, MO | 2026-10-27 | |
| 247 | $463 | 0.0% | Index | Low | San Francisco, CA | 2026-11-03 | |
| 184 | $0 | 0.0% | Value | High | London, United Kingdom | 2026-10-30 | |
| 152 | $285 | 0.0% | Index | Very Low | Foster City, CA | 2026-10-08 | |
| 142 | $267 | 0.0% | ETF | Medium | Boca Raton, FL | 2026-11-04 | |
| 5 | $10 | 0.0% | Core | Medium | Berkeley, CA | 2026-10-26 | |
| 2 | $4 | 0.0% | Index | Low | San Francisco, CA | 2026-10-08 |