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Upstream BIO Inc (UPB)

CUSIP: 91678A107 | NYSE | Healthcare · Biotechnology | Small Cap | 230 institutional holders

Quarters

Q3 2026Q2 2026Q1 2026Q4 2025Q3 2025
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Beneficial Ownership — 13D / 13G

Full history →

5%+ stakes reported outside the quarterly cycle. A 13D is due within five business days of the event below, so these figures lead the holders table until the filer's next 13F catches up to them.

HolderShares% of ClassChangeEvent Datevs 13F
13G/ADecheng Capital Global Life Sciences Fund IV, L.P.2,724,8684.9%Newly reportedSep 30, 2026No 13F filer matched
13G/ADecheng Capital Global Life Sciences Fund IV, L.P.2,724,868

Institutional Holders — Q3 2026

SEB Asset Management AB878,473
0.0% of portfolio›$4.6M
Y-Intercept (Hong Kong) Ltd642,574
0.1% of portfolio›$3.4M
Dimensional Fund Advisors LP374,836
0.0% of portfolio›$2.0M
Bank of New York Mellon Corp97,148
0.0% of portfolio›$512.0K
Alps Advisors Inc72,045
0.0% of portfolio›$379.7K
Simplify Asset Management Inc.62,113
0.0% of portfolio›$327.3K
Allspring Global Investments Holdings, LLC44,947
0.0% of portfolio›$236.9K
Citigroup Inc35,733
0.0% of portfolio›$188.3K
Strs Ohio30,600
0.0% of portfolio›$161.3K
Creative Planning15,456
0.0% of portfolio›$81.5K
China Universal Asset Management Co., Ltd.9,994
0.0% of portfolio›$51.9K
Simplex Trading, LLC3,078
0.0% of portfolio›$16.2K
Parallel Advisors, LLC3,050
0.0% of portfolio›$16.1K
Mirae Asset Global Investments Co., Ltd.2,799
0.0% of portfolio›$14.8K
Nisa Investment Advisors, LLC2,734
0.0% of portfolio›$14.4K
Gamma Investing LLC1,628
0.0% of portfolio›$8.6K
GF Fund Management Co. Ltd.1,245
0.0% of portfolio›$6.6K
Caitong International Asset Management Co., Ltd1,161
0.0% of portfolio›$6.1K
Sterling Capital Management LLC740
0.0% of portfolio›$3.9K
SJS Investment Consulting Inc.383
0.0% of portfolio›$2.0K
Farther Finance Advisors, LLC254
0.0% of portfolio›$1.3K
Signaturefd, LLC242
0.0% of portfolio›$1.3K
EverSource Wealth Advisors, LLC238
0.0% of portfolio›$1.3K
Essential Partners LLC95
0.0% of portfolio›$501
IFP Advisors, Inc90
0.0% of portfolio›$474
Silver Grove Financial Group, Inc.33
0.0% of portfolio›$174
Provenance Wealth Advisors, LLC30
0.0% of portfolio›$158
Covestor Ltd24
0.0% of portfolio›$0
Capital Advisors, Ltd. LLC11
0.0% of portfolio›$0
Root Financial Partners, LLC3
0.0% of portfolio›$16
True Wealth Design, LLC2
0.0% of portfolio›$11
StyleTurnoverLocationFiled
SEB Asset Management AB
878,473$4.6M0.0%CoreN/AStockholm, Sweden2026-11-04
Y-Intercept (Hong Kong) Ltd
642,574$3.4M0.1%ValueVery HighHong Kong, South Korea2026-10-16
Dimensional Fund Advisors LP
374,836$2.0M0.0%IndexLowAustin, TX2026-11-04
Bank of New York Mellon Corp
97,148$512.0K0.0%CoreLowNew York, NY2026-11-05
Alps Advisors Inc
72,045$379.7K0.0%YieldLowDenver, CO2026-11-03
Simplify Asset Management Inc.
62,113$327.3K0.0%CoreLowLas Vegas, NV2026-10-27
Allspring Global Investments Holdings, LLC
44,947$236.9K0.0%CoreMediumCharlotte, NC2026-11-04
Citigroup Inc
35,733$188.3K0.0%CoreMediumNew York, NY2026-11-04
Strs Ohio
30,600$161.3K0.0%CoreMediumColumbus, OH2026-10-30
Creative Planning
15,456$81.5K0.0%IndexVery LowOverland Park, KS2026-11-02
China Universal Asset Management Co., Ltd.
9,994$51.9K0.0%GrowthMediumShanghai, France2026-10-28
Simplex Trading, LLC
3,078$16.2K0.0%CoreVery HighChicago, IL2026-11-04
Parallel Advisors, LLC
3,050$16.1K0.0%IndexLowSan Francisco, CA2026-11-03
Mirae Asset Global Investments Co., Ltd.
2,799$14.8K0.0%GrowthLowSeoul, Malaysia2026-11-03
Nisa Investment Advisors, LLC
2,734$14.4K0.0%IndexVery LowSt. Louis, MO2026-10-20
Gamma Investing LLC
1,628$8.6K0.0%IndexVery LowFoster City, CA2026-10-08
GF Fund Management Co. Ltd.
1,245$6.6K0.0%Agg GrowthMediumGuangzhou, France2026-10-26
Caitong International Asset Management Co., Ltd
1,161$6.1K0.0%GrowthVery HighHong Kong, South Korea2026-10-29
Sterling Capital Management LLC
740$3.9K0.0%GARPMediumCharlotte, NC2026-10-22
SJS Investment Consulting Inc.
383$2.0K0.0%ETFVery LowSylvania, OH2026-10-26
Farther Finance Advisors, LLC
254$1.3K0.0%IndexLowSan Francisco, CA2026-10-08
Signaturefd, LLC
242$1.3K0.0%IndexLowAtlanta, GA2026-10-23
EverSource Wealth Advisors, LLC
238$1.3K0.0%CoreMediumBirmingham, AL2026-11-04
Essential Partners LLC
95$5010.0%ValueMediumRancho Santa Fe, CA2026-10-14
IFP Advisors, Inc
90$4740.0%GrowthLowTampa, FL2026-10-16
Silver Grove Financial Group, Inc.
33$1740.0%CoreMediumOrchard Park, NY2026-11-05
Provenance Wealth Advisors, LLC
30$1580.0%ETFLowFort Lauderdale, FL2026-10-30
Covestor Ltd
24$00.0%ValueHighLondon, United Kingdom2026-10-30
Capital Advisors, Ltd. LLC
11$00.0%ETFLowShaker Heights, OH2026-10-27
Root Financial Partners, LLC
3$160.0%ETFMediumEncinitas, CA2026-10-21
True Wealth Design, LLC
2$110.0%ETFMediumAkron, OH2026-10-13
4.9% of class · Sep 30, 2026
Newly reported
No 13F filer matched