Q4 2022 Holdings
Filed 2023-02-14 | 36 holdings | $6.7B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| United Therapeutics Corp(UTHR) | Common | 91307C102 | $796.7M | 2,865,000 | 11.9% |
| Horizon Therapeutics PLC | Common | G46188101 | $796.6M | 7,000,000 | 11.9% |
| Apellis Pharmaceuticals Inc(APLS) | Common | 03753U106 | $549.4M | 10,625,000 | 8.2% |
| Madrigal Pharmaceuticals Inc(MDGL) | Common | 558868105 | $481.8M | 1,660,000 | 7.2% |
| Argenx SE(ARGX) | Sponsored ADR | 04016X101 | $479.4M | 1,265,555 | 7.2% |
| Sarepta Therapeutics Inc(SRPT) | Common | 803607100 | $411.4M | 3,175,000 | 6.1% |
| Ascendis Pharma(ASND) | Sponsored ADR | 04351P101 | $378.6M | 3,100,000 | 5.7% |
| Biomarin Pharmaceutical Inc(BMRN) | Common | 09061G101 | $368.0M | 3,555,555 | 5.5% |
| Amicus Therapeutics Inc(FOLD) | Common | 03152W109 | $327.2M | 26,800,000 | 4.9% |
| Alnylam Pharmaceuticals Inc(ALNY) | Common | 02043Q107 | $262.6M | 1,105,000 | 3.9% |
| Mirati Therapeutics Inc(MRTXEUR) | Common | 60468T105 | $251.7M | 5,555,555 | 3.8% |
| Seagen Inc(SGENUSD) | Common | 81181C104 | $242.2M | 1,885,000 | 3.6% |
| Xenon Pharmaceuticals Inc(XENE) | Common | 98420N105 | $193.2M | 4,900,000 | 2.9% |
| Iveric BIO Inc(OPHTEUR) | Common | 46583P102 | $144.5M | 6,750,000 | 2.2% |
| Krystal Biotech Inc(KRYS) | Common | 501147102 | $111.7M | 1,410,000 | 1.7% |
| Biocryst Pharmaceuticals Inc(BCRX) | Common | 09058V103 | $103.9M | 9,050,000 | 1.6% |
| Kymera Therapeutics Inc(KYMR) | Common | 501575104 | $96.1M | 3,850,000 | 1.4% |
| Dice Therapeutics Inc | Common | 23345J104 | $78.8M | 2,525,555 | 1.2% |
| Syndax Pharmaceuticals Inc(SNDX) | Common | 87164F105 | $67.4M | 2,650,000 | 1.0% |
| Cymabay Therapeutics Inc(CBAYUSD) | Common | 23257D103 | $64.6M | 10,300,000 | 1.0% |
| Mannkind Corp(MNKD) | Common | 56400P706 | $48.0M | 9,100,000 | 0.7% |
| Nuvalent Inc(NUVL) | Common | 670703107 | $46.3M | 1,555,555 | 0.7% |
| Avidity Biosciences Inc(RNA) | Common | 05370A108 | $45.5M | 2,050,000 | 0.7% |
| Iovance Biotherapeutics Inc(IOVA) | Common | 462260100 | $44.9M | 7,020,000 | 0.7% |
| Mersana Therapeutics Inc | Common | 59045L106 | $44.2M | 7,550,000 | 0.7% |
| Kura Oncology Inc(KURA) | Common | 50127T109 | $38.5M | 3,105,000 | 0.6% |
| Aadi Biosciences Inc(WHWK) | Common | 00032Q104 | $36.6M | 2,849,402 | 0.5% |
| Ultragenyx Pharmaceutical Inc(RARE) | Common | 90400D108 | $34.7M | 750,000 | 0.5% |
| Monte Rosa Therapeutics Inc(GLUE) | Common | 61225M102 | $32.9M | 4,325,000 | 0.5% |
| PMV Pharmaceuticals Inc(PMVP) | Common | 69353Y103 | $26.6M | 3,060,000 | 0.4% |
| Design Therapeutics Inc(DSGN) | Common | 25056L103 | $23.3M | 2,272,222 | 0.3% |
| Amylyx Pharmaceuticals Inc(AMLX) | Common | 03237H101 | $23.3M | 630,000 | 0.3% |
| Marinus Pharmaceuticals Inc(MRNS*) | Common | 56854Q200 | $12.5M | 3,150,000 | 0.2% |
| Tango Therapeutics Inc(TNGX) | Common | 87583X109 | $11.9M | 1,640,000 | 0.2% |
| Fennec Pharmaceuticals Inc(FENC) | Common | 31447P100 | $11.5M | 1,200,000 | 0.2% |
| IO Biotech Inc(IOBT) | Common | 449778109 | $4.7M | 2,055,883 | 0.1% |