Q4 2022 Holdings
Filed 2023-02-14 | 113 holdings | $16.7B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Seagen Inc.(SGENUSD) | COM | 81181C104 | $6.0B | 46,912,266 | 36.2% |
| Incyte Corporation(INCY) | COM | 45337C102 | $2.9B | 36,154,971 | 17.4% |
| BeiGene, Ltd.(ONC) | SPONSORED ADR | 07725L102 | $2.6B | 11,668,897 | 15.4% |
| BioMarin Pharmaceutical Inc.(BMRN) | COM | 09061G101 | $788.6M | 7,620,494 | 4.7% |
| Acadia Pharmaceuticals Inc.(ACAD) | COM | 004225108 | $667.4M | 41,923,486 | 4.0% |
| Ascendis Pharma A/S(ASND) | SPONSORED ADR | 04351P101 | $605.1M | 4,954,855 | 3.6% |
| Madrigal Pharmaceuticals, Inc.(MDGL) | COM | 558868105 | $448.5M | 1,545,113 | 2.7% |
| Rhythm Pharmaceuticals, Inc.(RYTM) | COM | 76243J105 | $185.0M | 6,354,608 | 1.1% |
| BioCryst Pharmaceuticals, Inc.(BCRX) | COM | 09058V103 | $145.9M | 12,710,818 | 0.9% |
| Immunocore Holdings plc(IMCR) | ADS | 45258D105 | $143.9M | 2,520,731 | 0.9% |
| Akero Therapeutics, Inc.(AKRO) | COM | 00973Y108 | $129.8M | 2,368,378 | 0.8% |
| Replimune Group, Inc.(REPL) | COM | 76029N106 | $124.5M | 4,578,280 | 0.7% |
| Kodiak Sciences Inc.(KOD) | COM | 50015M109 | $123.9M | 17,310,490 | 0.7% |
| Horizon Therapeutics Public Ltd Co | SHS | G46188101 | $110.4M | 969,727 | 0.7% |
| argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $106.1M | 280,159 | 0.6% |
| AbCellera Biologics Inc.(ABCL) | COM | 00288U106 | $105.9M | 10,450,180 | 0.6% |
| Kymera Therapeutics, Inc.(KYMR) | COM | 501575104 | $71.9M | 2,879,825 | 0.4% |
| Chinook Therapeutics, Inc.(290A) | COM | 16961L106 | $66.4M | 2,534,102 | 0.4% |
| Entrada Therapeutics, Inc.(TRDA) | COM | 29384C108 | $65.8M | 4,865,819 | 0.4% |
| Mirati Therapeutics, Inc.(MRTXEUR) | COM | 60468T105 | $63.9M | 1,409,784 | 0.4% |
| Prelude Therapeutics Inc.(PRLD) | COM | 74065P101 | $61.1M | 10,123,824 | 0.4% |
| Cerus Corporation(CERS) | COM | 157085101 | $58.6M | 16,067,558 | 0.4% |
| Aerovate Therapeutics, Inc. | COM | 008064107 | $57.9M | 1,976,868 | 0.3% |
| IGM Biosciences, Inc.(1K0) | COM | 449585108 | $53.7M | 3,156,102 | 0.3% |
| Immatics N.V.(IMTX) | SHS | N44445109 | $45.2M | 5,187,081 | 0.3% |
| Nurix Therapeutics, Inc.(NRIX) | COM | 67080M103 | $42.6M | 3,882,125 | 0.3% |
| Kiniksa Pharmaceuticals, Ltd. | COM CL A | G5269C101 | $41.9M | 2,799,577 | 0.3% |
| SpringWorks Therapeutics, Inc. | COM | 85205L107 | $39.8M | 1,528,538 | 0.2% |
| Ideaya Biosciences, Inc.(IDYA) | COM | 45166A102 | $30.3M | 1,668,355 | 0.2% |
| Denali Therapeutics Inc.(DNLI) | COM | 24823R105 | $30.3M | 1,088,738 | 0.2% |
| Xenon Pharmaceuticals Inc.(XENE) | COM | 98420N105 | $29.6M | 751,639 | 0.2% |
| Verve Therapeutics, Inc. | COM | 92539P101 | $27.4M | 1,416,530 | 0.2% |
| Dice Therapeutics, Inc. | COM | 23345J104 | $26.9M | 862,207 | 0.2% |
| Travere Therapeutics, Inc.(TVTX) | COM | 89422G107 | $25.8M | 1,225,255 | 0.2% |
| Bicycle Therapeutics plc(BCYC) | SPONSORED ADS | 088786108 | $25.0M | 843,814 | 0.1% |
| AnaptysBio, Inc.(ANAB) | COM | 032724106 | $24.0M | 775,924 | 0.1% |
| Krystal Biotech, Inc.(KRYS) | COM | 501147102 | $24.0M | 302,716 | 0.1% |
| DBV Technologies S.A. | SPONSORED ADR | 23306J101 | $22.4M | 14,614,264 | 0.1% |
| FibroGen, Inc.(FGENEUR) | COM | 31572Q808 | $22.0M | 1,375,211 | 0.1% |
| Ultragenyx Pharmaceutical Inc.(RARE) | COM | 90400D108 | $21.8M | 470,974 | 0.1% |
| Heron Therapeutics, Inc.(HRTX) | COM | 427746102 | $20.3M | 8,131,678 | 0.1% |
| 2seventy bio, Inc.(TSVT*) | COM | 901384107 | $19.3M | 2,062,744 | 0.1% |
| Insmed Incorporated | Note 0.75% 6/1/2028 | 457669AB5 | $19.2M | $23,500,000 | 0.1% |
| Prime Medicine, Inc.(PRME) | COM | 74168J101 | $19.1M | 1,028,466 | 0.1% |
| Biomea Fusion, Inc.(BMEA) | COM | 09077A106 | $17.7M | 2,104,559 | 0.1% |
| bluebird bio, Inc. | COM | 09609G100 | $17.3M | 2,499,715 | 0.1% |
| ARS Pharmaceuticals, Inc.(SPRY) | COM | 82835W108 | $17.1M | 2,006,451 | 0.1% |
| Invitae Corporation(NVTA1EUR) | COM | 46185L103 | $15.6M | 8,402,035 | 0.1% |
| Opthea Limited | SPONSORED ADS | 68386J208 | $14.4M | 2,691,391 | 0.1% |
| Adaptimmune Therapeutics plc(ADAPY) | SPONSORED ADR | 00653A107 | $14.4M | 9,830,877 | 0.1% |