Q1 2023 Holdings
Filed 2023-05-15 | 105 holdings | $18.4B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Seagen Inc.(SGENUSD) | COM | 81181C104 | $9.5B | 46,913,769 | 51.7% |
| Incyte Corporation(INCY) | COM | 45337C102 | $2.6B | 36,175,400 | 14.2% |
| BeiGene, Ltd.(ONC) | SPONSORED ADR | 07725L102 | $2.5B | 11,668,897 | 13.7% |
| Acadia Pharmaceuticals Inc.(ACAD) | COM | 004225108 | $789.3M | 41,938,486 | 4.3% |
| Madrigal Pharmaceuticals, Inc.(MDGL) | COM | 558868105 | $374.3M | 1,545,113 | 2.0% |
| BioMarin Pharmaceutical Inc.(BMRN) | COM | 09061G101 | $370.5M | 3,810,248 | 2.0% |
| Immunocore Holdings plc(IMCR) | ADS | 45258D105 | $124.6M | 2,520,731 | 0.7% |
| Rhythm Pharmaceuticals, Inc.(RYTM) | COM | 76243J105 | $115.9M | 6,498,267 | 0.6% |
| Kodiak Sciences Inc.(KOD) | COM | 50015M109 | $107.3M | 17,310,490 | 0.6% |
| BioCryst Pharmaceuticals, Inc.(BCRX) | COM | 09058V103 | $106.0M | 12,710,818 | 0.6% |
| argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $104.4M | 280,159 | 0.6% |
| Akero Therapeutics, Inc.(AKRO) | COM | 00973Y108 | $90.6M | 2,368,378 | 0.5% |
| Kymera Therapeutics, Inc.(KYMR) | COM | 501575104 | $85.3M | 2,879,825 | 0.5% |
| Replimune Group, Inc.(REPL) | COM | 76029N106 | $80.9M | 4,578,280 | 0.4% |
| AbCellera Biologics Inc.(ABCL) | COM | 00288U106 | $78.8M | 10,450,180 | 0.4% |
| SpringWorks Therapeutics, Inc. | COM | 85205L107 | $70.9M | 2,753,502 | 0.4% |
| Entrada Therapeutics, Inc.(TRDA) | COM | 29384C108 | $70.6M | 4,865,819 | 0.4% |
| Biomea Fusion, Inc.(BMEA) | COM | 09077A106 | $65.4M | 2,108,949 | 0.4% |
| Revolution Medicines, Inc.(RVMD) | COM | 76155X100 | $58.3M | 2,691,493 | 0.3% |
| Prelude Therapeutics Inc.(PRLD) | COM | 74065P101 | $57.7M | 10,123,824 | 0.3% |
| Mirati Therapeutics, Inc.(MRTXEUR) | COM | 60468T105 | $52.4M | 1,409,784 | 0.3% |
| FibroGen, Inc.(FGENEUR) | COM | 31572Q808 | $49.2M | 2,637,384 | 0.3% |
| Cerus Corporation(CERS) | COM | 157085101 | $47.7M | 16,067,558 | 0.3% |
| IGM Biosciences, Inc.(1K0) | COM | 449585108 | $43.4M | 3,156,656 | 0.2% |
| Aerovate Therapeutics, Inc. | COM | 008064107 | $39.6M | 1,963,479 | 0.2% |
| Immatics N.V.(IMTX) | SHS | N44445109 | $35.8M | 5,187,081 | 0.2% |
| Roivant Sciences Ltd.(ROIV) | SHS | G76279101 | $35.3M | 4,777,430 | 0.2% |
| Nurix Therapeutics, Inc.(NRIX) | COM | 67080M103 | $34.5M | 3,882,125 | 0.2% |
| Chinook Therapeutics, Inc.(290A) | COM | 16961L106 | $33.7M | 1,455,202 | 0.2% |
| Kiniksa Pharmaceuticals, Ltd. | COM CL A | G5269C101 | $30.1M | 2,799,577 | 0.2% |
| Dice Therapeutics, Inc. | COM | 23345J104 | $29.7M | 1,035,786 | 0.2% |
| Xenon Pharmaceuticals Inc.(XENE) | COM | 98420N105 | $26.9M | 751,639 | 0.1% |
| 2seventy bio, Inc.(TSVT*) | COM | 901384107 | $25.5M | 2,497,526 | 0.1% |
| Denali Therapeutics Inc.(DNLI) | COM | 24823R105 | $25.1M | 1,088,738 | 0.1% |
| DBV Technologies S.A. | SPONSORED ADR | 23306J101 | $24.7M | 14,614,264 | 0.1% |
| Krystal Biotech, Inc.(KRYS) | COM | 501147102 | $24.2M | 302,716 | 0.1% |
| Verve Therapeutics, Inc. | COM | 92539P101 | $20.4M | 1,416,530 | 0.1% |
| Ultragenyx Pharmaceutical Inc.(RARE) | COM | 90400D108 | $18.9M | 470,974 | 0.1% |
| Bicycle Therapeutics plc(BCYC) | SPONSORED ADS | 088786108 | $17.9M | 843,814 | 0.1% |
| Stoke Therapeutics, Inc.(STOK) | COM | 86150R107 | $17.6M | 2,115,416 | 0.1% |
| AnaptysBio, Inc.(ANAB) | COM | 032724106 | $16.9M | 775,924 | 0.1% |
| Avidity Biosciences, Inc.(RNA) | COM | 05370A108 | $15.4M | 1,004,051 | 0.1% |
| Blueprint Medicines Corporation(2L9) | COM | 09627Y109 | $15.0M | 333,665 | 0.1% |
| ARS Pharmaceuticals, Inc.(SPRY) | COM | 82835W108 | $13.1M | 2,006,451 | 0.1% |
| Pacific Biosciences of California, Inc.(PACB) | COM | 69404D108 | $13.1M | 1,127,782 | 0.1% |
| Prime Medicine, Inc.(PRME) | COM | 74168J101 | $12.7M | 1,028,466 | 0.1% |
| Heron Therapeutics, Inc.(HRTX) | COM | 427746102 | $12.3M | 8,131,678 | 0.1% |
| Invitae Corporation(NVTA1EUR) | COM | 46185L103 | $12.0M | 8,881,104 | 0.1% |
| Ideaya Biosciences, Inc.(IDYA) | COM | 45166A102 | $11.4M | 832,769 | 0.1% |
| Cabaletta Bio, Inc.(CABA) | COM | 12674W109 | $11.1M | 1,344,000 | 0.1% |