Q2 2025 Holdings
Filed 2025-08-14 | 89 holdings | $10.3B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| BeOne Medicines Ltd.(ONC) | SPONSORED ADS | 07725L102 | $2.1B | 8,799,053 | 20.7% |
| Incyte Corporation(INCY) | COM | 45337C102 | $2.1B | 30,743,275 | 20.3% |
| Acadia Pharmaceuticals Inc.(ACAD) | COM | 004225108 | $925.3M | 42,896,690 | 9.0% |
| Insmed Incorporated(INSM) | COM PAR $.01 | 457669307 | $776.2M | 7,712,900 | 7.5% |
| Summit Therapeutics Inc.(SMMT) | COM | 86627T108 | $717.6M | 33,722,974 | 7.0% |
| Madrigal Pharmaceuticals, Inc.(MDGL) | COM | 558868105 | $598.0M | 1,976,018 | 5.8% |
| Rhythm Pharmaceuticals, Inc.(RYTM) | COM | 76243J105 | $354.1M | 5,604,483 | 3.4% |
| Revolution Medicines, Inc.(RVMD) | COM | 76155X100 | $344.5M | 9,364,972 | 3.3% |
| Kymera Therapeutics, Inc.(KYMR) | COM | 501575104 | $290.3M | 6,651,429 | 2.8% |
| Alkermes plc(ALKS) | SHS | G01767105 | $183.4M | 6,410,603 | 1.8% |
| Replimune Group, Inc.(REPL) | COM | 76029N106 | $102.6M | 11,045,336 | 1.0% |
| Ultragenyx Pharmaceutical Inc.(RARE) | COM | 90400D108 | $100.8M | 2,772,692 | 1.0% |
| Edgewise Therapeutics, Inc.(EWTX) | COM | 28036F105 | $95.8M | 7,305,940 | 0.9% |
| AbCellera Biologics Inc.(ABCL) | COM | 00288U106 | $94.4M | 27,525,640 | 0.9% |
| Immunovant, Inc.(IMVT) | COM | 45258J102 | $87.3M | 5,457,881 | 0.8% |
| Grail, Inc.(GRAL) | COM | 384747101 | $83.8M | 1,630,125 | 0.8% |
| Kiniksa Pharmaceuticals International, plc(KNSA) | ORD SHS CL A | G52694109 | $78.2M | 2,824,669 | 0.8% |
| Bicycle Therapeutics plc(BCYC) | SPONSORED ADS | 088786108 | $75.7M | 10,885,357 | 0.7% |
| Immunocore Holdings plc(IMCR) | ADS | 45258D105 | $72.9M | 2,322,656 | 0.7% |
| Celcuity Inc.(CELC) | COM | 15102K100 | $72.8M | 5,450,445 | 0.7% |
| Kodiak Sciences Inc.(KOD) | COM | 50015M109 | $64.6M | 17,310,490 | 0.6% |
| Immatics N.V.(IMTX) | SHS | N44445109 | $54.7M | 10,168,901 | 0.5% |
| Stoke Therapeutics, Inc.(STOK) | COM | 86150R107 | $52.6M | 4,633,838 | 0.5% |
| Denali Therapeutics Inc.(DNLI) | COM | 24823R105 | $52.2M | 3,731,695 | 0.5% |
| Structure Therapeutics Inc.(GPCR) | SPONSORED ADS | 86366E106 | $52.0M | 2,508,767 | 0.5% |
| Ideaya Biosciences, Inc.(IDYA) | COM | 45166A102 | $44.5M | 2,118,728 | 0.4% |
| Nurix Therapeutics, Inc.(NRIX) | COM | 67080M103 | $44.2M | 3,882,125 | 0.4% |
| Roivant Sciences Ltd.(ROIV) | SHS | G76279101 | $42.5M | 3,767,773 | 0.4% |
| BioNTech SE(BNTX) | SPONSORED ADS | 09075V102 | $39.3M | 368,923 | 0.4% |
| Entrada Therapeutics, Inc.(TRDA) | COM | 29384C108 | $32.7M | 4,865,819 | 0.3% |
| Merus N.V. | COM | N5749R100 | $30.2M | 574,377 | 0.3% |
| Praxis Precision Medicines, Inc.(PRAX) | COM | 74006W207 | $29.0M | 689,488 | 0.3% |
| Intellia Therapeutics, Inc.(NTLA) | COM | 45826J105 | $25.1M | 2,675,674 | 0.2% |
| Viridian Therapeutics, Inc.(VRDN) | COM | 92790C104 | $24.4M | 1,744,406 | 0.2% |
| Monte Rosa Therapeutics, Inc.(GLUE) | COM | 61225M102 | $22.2M | 4,916,095 | 0.2% |
| Verona Pharma plc(VRNA) | SPONSORED ADS | 925050106 | $21.2M | 223,843 | 0.2% |
| Vaxcyte, Inc.(PCVX) | COM | 92243G108 | $20.8M | 640,885 | 0.2% |
| argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $20.8M | 37,760 | 0.2% |
| Verve Therapeutics, Inc. | COM | 92539P101 | $19.0M | 1,691,530 | 0.2% |
| Cerus Corporation(CERS) | COM | 157085101 | $18.2M | 12,883,844 | 0.2% |
| Disc Medicine, Inc.(IRON) | COM | 254604101 | $17.9M | 337,050 | 0.2% |
| Akero Therapeutics, Inc.(AKRO) | COM | 00973Y108 | $17.3M | 324,630 | 0.2% |
| Blueprint Medicines Corporation(2L9) | COM | 09627Y109 | $16.1M | 125,538 | 0.2% |
| Sera Prognostics, Inc.(SERA) | CLASS A COM | 81749D107 | $15.2M | 5,498,170 | 0.1% |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | COM | 04280A100 | $14.8M | 939,174 | 0.1% |
| Neurogene Inc.(NGNE) | COM | 64135M105 | $14.8M | 991,691 | 0.1% |
| Dianthus Therapeutics, Inc.(DNTH) | COM | 252828108 | $14.7M | 789,759 | 0.1% |
| Celldex Therapeutics, Inc.(CLDX) | COM | 15117B202 | $13.5M | 665,370 | 0.1% |
| DBV Technologies S.A.(DBVT) | SPONSORED ADS | 23306J309 | $13.4M | 1,461,425 | 0.1% |
| Xenon Pharmaceuticals Inc.(XENE) | COM | 98420N105 | $11.6M | 370,208 | 0.1% |