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Sio Capital Management, LLC

Q4 2025 Holdings

Filed 2026-02-17 | 68 holdings | $635.7M | 13F-HR | View on SEC ↗ · Holdings Table ↗

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IssuerClassCUSIPValue ↓Shares% Portfolio
Celcuity Inc(CELC)COM15102K100$47.6M477,0677.5%
The Cigna Group(CI)COM125523100$47.4M172,2037.5%
Sanofi SA(SNY)SPONSORED ADR80105N105$47.1M971,6867.4%
Maximus Inc(MMS)COM577933104$43.2M500,3046.8%
Zimmer Biomet Holdings Inc(ZBH)COM98956P102$34.7M385,6425.5%
Rhythm Pharmaceuticals Inc(RYTM)PutCOM76243J105$28.4M265,7004.5%
Kenvue Inc(KVUE)COM49177J102$25.3M1,465,4424.0%
Organon & Co(OGN)COMMON STOCK68622V106$24.5M3,421,7653.9%
Icon PLC(ICLR)SHSG4705A100$23.2M127,2023.6%
Waystar Hldg Corp(WAY)COM946784105$20.1M613,7253.2%
Livanova PLC(LIVN)SHSG5509L101$19.8M322,3823.1%
Dianthus Therapeutics Inc(DNTH)COM252828108$19.6M474,5033.1%
Biohaven LTD(BHVN)COMG1110E107$14.1M1,244,7642.2%
Structure Therapeutics Inc(GPCR)SPONSORED ADS86366E106$14.0M201,5002.2%
Biomarin Pharmaceutical Inc(BMRN)COM09061G101$13.8M232,6882.2%
Tyra Biosciences Inc(TYRA)COM90240B106$13.8M526,0022.2%
Brightspring Health Svcs Inc(BTSG)COM10950A106$11.5M308,0101.8%
Centene Corp del(CNC)COM15135B101$11.3M274,3501.8%
Charles RIV Labs Intl Inc(CRL)COM159864107$11.0M54,9851.7%
Teleflex Incorporated(TFX)COM879369106$10.6M86,8761.7%
Anteris Technologies Global(AVR)COM03675P102$9.4M1,874,6411.5%
Protara Therapeutics Inc(TARA)COM STK74365U107$9.1M1,715,3941.4%
Cross Ctry Healthcare Inc(CCRN)COM227483104$8.7M1,068,8211.4%
Haemonetics Corp Mass(HAE)COM405024100$7.4M92,6311.2%
ANI Pharmaceuticals Inc(ANIP)COM00182C103$6.9M87,2721.1%
Aquestive Therapeutics Inc(AQST)COM03843E104$6.4M993,0951.0%
Bright Minds Biosciences Inc(DRUG)COM NEW10919W405$6.4M81,8831.0%
Edgewise Therapeutics Inc(EWTX)COM28036F105$5.9M237,4810.9%
Abivax SA(ABVX)SPONSORED ADS00370M103$5.8M43,1240.9%
Crinetics Pharmaceuticals in(CRNX)COM22663K107$5.8M124,8410.9%
Rapport Therapeutics Inc(RAPP)COM75383L102$5.6M185,2650.9%
Cencora Inc(COR)COM03073E105$5.4M15,9000.8%
Mckesson Corp(MCK)COM58155Q103$5.2M6,4000.8%
Disc Medicine Inc(IRON)COM254604101$4.6M57,5860.7%
Proqr Therapeutics N VSHS EURON71542109$4.4M2,164,1810.7%
Fulcrum Therapeutics Inc(FULC)COM359616109$4.3M382,0000.7%
Savara Inc(SVRA)COM805111101$3.7M613,8880.6%
Oruka Therapeutics Inc(ORKA)COM687604108$3.6M118,1260.6%
Ventyx Biosciences Inc(VTYX)COM92332V107$3.5M387,7510.6%
PMV Pharmaceuticals Inc(PMVP)COM69353Y103$3.3M2,636,5480.5%
Shoulder Innovations Inc(SI)COMMON STOCK82537J108$3.3M227,9710.5%
Aligos Therapeutics Inc(ALGS)COM NEW01626L204$3.1M335,9370.5%
VIR Biotechnology Inc(VIR)COM92764N102$2.9M478,3430.5%
Alkermes PLC(ALKS)SHSG01767105$2.7M95,3530.4%
Ideaya Biosciences Inc(IDYA)COM45166A102$2.6M75,7300.4%
Kymera Therapeutics Inc(KYMR)COM501575104$2.5M32,2350.4%
Elicio Therapeutics Inc(ELTX)PutCOM28657F103$2.4M296,9000.4%
Ovid Therapeutics Inc(OVID)COM690469101$2.3M1,427,4950.4%
Context Therapeutics Inc(CNTX)COM21077P108$2.0M1,341,6360.3%
Hyperfine Inc(HYPR)COM CL A44916K106$2.0M2,000,0000.3%
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