Q4 2022 Holdings
Filed 2023-02-14 | 60 holdings | $2.4B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Immunovant Inc(IMVT) | COM | 45258J102 | $172.4M | 9,710,000 | 7.2% |
| Iveric BIO Inc(OPHTEUR) | COM | 46583P102 | $168.7M | 7,878,119 | 7.1% |
| Jazz Pharmaceuticals PLC(JAZZ) | SHS USD | G50871105 | $139.2M | 873,553 | 5.8% |
| Travere Therapeutics Inc(TVTX) | COM | 89422G107 | $96.4M | 4,582,000 | 4.0% |
| Ascendis Pharma A/S(ASND) | SPONSORED ADR | 04351P101 | $85.5M | 700,000 | 3.6% |
| Insmed Inc(INSM) | COM PAR $.01 | 457669307 | $85.2M | 4,264,292 | 3.6% |
| Bicycle Therapeutics PLC(BCYC) | SPONSORED ADS | 088786108 | $83.4M | 2,819,045 | 3.5% |
| Verona Pharma PLC(VRNA) | SPONSORED ADS | 925050106 | $83.3M | 3,187,415 | 3.5% |
| Biogen Inc(BIIB) | COM | 09062X103 | $83.1M | 300,000 | 3.5% |
| Springworks Therapeutics Inc | COM | 85205L107 | $80.9M | 3,109,886 | 3.4% |
| Chinook Therapeutics Inc(290A) | COM | 16961L106 | $78.6M | 3,000,000 | 3.3% |
| Sarepta Therapeutics Inc(SRPT) | COM | 803607100 | $68.4M | 528,244 | 2.9% |
| Agenus Inc(AGENEUR) | COM NEW | 00847G705 | $64.8M | 27,000,000 | 2.7% |
| 4D Molecular Therapeutics in(FDMT) | COM | 35104E100 | $59.0M | 2,656,901 | 2.5% |
| Horizon Therapeutics PUB L | SHS | G46188101 | $56.9M | 500,000 | 2.4% |
| Horizon Therapeutics PUB LPut | SHS | G46188101 | $56.9M | 500,000 | 2.4% |
| Dice Therapeutics Inc | COM | 23345J104 | $54.1M | 1,734,143 | 2.3% |
| Viridian Therapeutics Inc(VRDN) | COM | 92790C104 | $51.7M | 1,771,154 | 2.2% |
| 89Bio Inc(ETNBGBP) | COM | 282559103 | $49.0M | 3,850,000 | 2.1% |
| Beam Therapeutics Inc(BEAM) | COM | 07373V105 | $45.6M | 1,166,473 | 1.9% |
| Ionis Pharmaceuticals Inc(IONS) | COM | 462222100 | $45.5M | 1,205,773 | 1.9% |
| Allakos Inc(ALLKGUSD) | COM | 01671P100 | $41.3M | 4,899,179 | 1.7% |
| Repare Therapeutics Inc(RPTX) | COM | 760273102 | $40.1M | 2,727,606 | 1.7% |
| Albireo Pharma Inc(BDQM) | COM | 01345P106 | $36.8M | 1,704,000 | 1.5% |
| Pliant Therapeutics Inc(PLRX) | COM | 729139105 | $33.5M | 1,732,946 | 1.4% |
| Dyne Therapeutics Inc(DYN) | COM | 26818M108 | $31.1M | 2,684,200 | 1.3% |
| Ascendis Pharma A/S(ASND)Call | SPONSORED ADR | 04351P101 | $30.4M | 249,300 | 1.3% |
| Edgewise Therapeutics Inc(EWTX) | COM | 28036F105 | $30.2M | 3,374,394 | 1.3% |
| Silence Therapeutics PLC(SLN) | ADS | 82686Q101 | $29.8M | 1,951,580 | 1.2% |
| Autolus Therapeutics PLC(AUTL) | SPON ADS | 05280R100 | $28.5M | 15,000,000 | 1.2% |
| Astria Therapeutics Inc(CATBUSD) | COM | 04635X102 | $27.0M | 1,816,531 | 1.1% |
| Vigil Neuroscience Inc(VIGL) | COM | 92673K108 | $26.3M | 2,104,174 | 1.1% |
| Rapt Therapeutics Inc(RAPTEUR) | COM | 75382E109 | $25.8M | 1,304,940 | 1.1% |
| Esperion Therapeutics Inc NE(ESPR) | COM | 29664W105 | $24.9M | 4,000,000 | 1.0% |
| Nurix Therapeutics Inc(NRIX) | COM | 67080M103 | $24.9M | 2,266,569 | 1.0% |
| Dynavax Technologies Corp(DVAX) | COM NEW | 268158201 | $24.8M | 2,327,951 | 1.0% |
| Intellia Therapeutics Inc(NTLA) | COM | 45826J105 | $24.4M | 700,000 | 1.0% |
| Acumen Pharmaceuticals Inc(ABOS) | COM | 00509G209 | $21.3M | 3,952,000 | 0.9% |
| Biomarin Pharmaceutical Inc(BMRN) | COM | 09061G101 | $19.6M | 189,800 | 0.8% |
| Crinetics Pharmaceuticals in(CRNX) | COM | 22663K107 | $19.2M | 1,048,829 | 0.8% |
| Geron Corp(GERN) | COM | 374163103 | $17.9M | 7,414,693 | 0.8% |
| Heron Therapeutics Inc(HRTX) | COM | 427746102 | $16.2M | 6,496,976 | 0.7% |
| Nuvation BIO Inc(NUVB) | COM CL A | 67080N101 | $15.8M | 8,221,188 | 0.7% |
| Syndax Pharmaceuticals Inc(SNDX) | COM | 87164F105 | $12.7M | 500,000 | 0.5% |
| Relmada Therapeutics Inc(RLMD) | COM | 75955J402 | $9.9M | 2,837,818 | 0.4% |
| Protagonist Therapeutics Inc(PTGX) | COM | 74366E102 | $9.5M | 871,493 | 0.4% |
| Nkarta Inc(NKTX) | COM | 65487U108 | $8.1M | 1,354,200 | 0.3% |
| Avidity Biosciences Inc(RNA) | COM | 05370A108 | $6.7M | 300,000 | 0.3% |
| Viking Therapeutics Inc(VKTX) | COM | 92686J106 | $5.7M | 610,083 | 0.2% |
| Fulcrum Therapeutics Inc(FULC) | COM | 359616109 | $5.6M | 768,607 | 0.2% |