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Siren, L.L.C.

Portfolio Profile

CIK: 0002005245 | New York, NY

Investment Profile

Style

Growth

Turnover

Medium

Orientation

Concentrated trader
$4.9B
AUM
115
Positions
44.77%
Top 10 Conc.
69.42%
Top 25 Conc.

Top Holdings

#SecuritySharesValue% of Portfolio
1Scholar Rock Holding Corp(SRRK)9,575,013$526.6M10.66%
2Kymera Therapeutics Inc(KYMR)2,935,830$336.7M6.81%
3Erasca Inc(ERAS)11,397,781$208.8M4.23%
4Veradermics Inc(MANE)1,655,374$203.5M4.12%
5Tango Therapeutics Inc(TNGX)6,179,364$193.2M3.91%

Sector Allocation

Latest filing, equity positions only

Healthcare82.96% · $4.1B
Unclassified11.86% · $584.1M
Technology3.31% · $163.0M
Communication Services0.71% · $35.0M
Financial Services0.7% · $34.4M
Consumer Cyclical0.43% · $21.3M
Real Estate0.03% · $1.5M

AUM History

$2.0B | 112 pos.
$2.3B | 119 pos.
$1.8B | 117 pos.
$1.9B | 111 pos.
$2.6B | 117 pos.
$3.4B | 115 pos.
6
Revolution Medicines Inc(RVMD)
900,000
$168.6M
3.41%
7Bicara Therapeutics Inc(BCAX)5,602,970$166.4M3.37%
8Arrowhead Pharmaceuticals Inc(ARWR)1,715,476$139.8M2.83%
9BeOne Medicines AG(ONC)465,000$132.5M2.68%
10Edgewise Therapeutics Inc(EWTX)3,184,629$129.4M2.62%

Sector Rotation

Quarter-over-quarter weight changes

SectorPrev %Curr %Change
Healthcare88.78%82.96%-5.82%
Unclassified6.29%11.86%+5.57%
Financial Services0%0.7%+0.7%
Consumer Cyclical0.77%0.43%-0.34%
Communication Services0.52%0.71%+0.19%
Technology3.48%3.31%-0.17%
Industrials0.08%0%-0.08%
Consumer Defensive0.03%0%-0.03%
Real Estate0.04%0.03%-0.01%

Cap Size Rotation

Quarter-over-quarter weight changes by market cap

Cap SizePrev %Curr %Change
Mid Cap56.93%50.7%-6.23%
Small Cap24.45%25.06%+0.61%
Unclassified6.29%11.86%+5.57%
Large Cap8.18%8.01%-0.17%
Mega Cap2.45%2.27%-0.18%
Micro Cap1.7%2.1%+0.4%
$3.6B | 102 pos.
$4.9B | 119 pos.
Q3
24
Q4
24
Q1
25
Q2
25
Q3
25
Q4
25
Q1
26
Q2
26

Recent Activity

Quarter-over-quarter position changes

26
New
9
Closed
32
Increased
21
Decreased
38
Unchanged