Q4 2024 Holdings
Filed 2025-02-14 | 95 holdings | $9.4B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Incyte Corporation(INCY) | COM | 45337C102 | $2.1B | 30,739,466 | 22.7% |
| BeiGene, Ltd.(ONC) | SPONSORED ADR | 07725L102 | $1.8B | 9,531,880 | 18.8% |
| Acadia Pharmaceuticals Inc.(ACAD) | COM | 004225108 | $786.8M | 42,877,916 | 8.4% |
| Madrigal Pharmaceuticals, Inc.(MDGL) | COM | 558868105 | $609.3M | 1,974,590 | 6.5% |
| Summit Therapeutics Inc.(SMMT) | COM | 86627T108 | $435.9M | 24,424,865 | 4.7% |
| Revolution Medicines, Inc.(RVMD) | COM | 76155X100 | $347.2M | 7,936,972 | 3.7% |
| Insmed Incorporated(INSM) | COM PAR $.01 | 457669307 | $345.7M | 5,006,863 | 3.7% |
| Rhythm Pharmaceuticals, Inc.(RYTM) | COM | 76243J105 | $340.6M | 6,084,249 | 3.6% |
| Kymera Therapeutics, Inc.(KYMR) | COM | 501575104 | $241.2M | 5,995,929 | 2.6% |
| Kodiak Sciences Inc.(KOD) | COM | 50015M109 | $172.2M | 17,310,490 | 1.8% |
| Edgewise Therapeutics, Inc.(EWTX) | COM | 28036F105 | $164.4M | 6,155,940 | 1.8% |
| Bicycle Therapeutics plc(BCYC) | SPONSORED ADS | 088786108 | $152.4M | 10,885,357 | 1.6% |
| Replimune Group, Inc.(REPL) | COM | 76029N106 | $133.8M | 11,045,336 | 1.4% |
| Alkermes plc(ALKS) | SHS | G01767105 | $120.3M | 4,181,751 | 1.3% |
| Insmed Incorporated | Note 0.75% 6/1/2028 | 457669AB5 | $92.9M | $42,850,000 | 1.0% |
| Entrada Therapeutics, Inc.(TRDA) | COM | 29384C108 | $84.1M | 4,865,819 | 0.9% |
| AbCellera Biologics Inc.(ABCL) | COM | 00288U106 | $80.7M | 27,525,640 | 0.9% |
| Denali Therapeutics Inc.(DNLI) | COM | 24823R105 | $76.1M | 3,731,695 | 0.8% |
| Nurix Therapeutics, Inc.(NRIX) | COM | 67080M103 | $73.1M | 3,882,125 | 0.8% |
| argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $68.8M | 111,904 | 0.7% |
| Ultragenyx Pharmaceutical Inc.(RARE) | COM | 90400D108 | $66.3M | 1,576,114 | 0.7% |
| Kiniksa Pharmaceuticals International, plc(KNSA) | ORD SHS CL A | G52694109 | $55.7M | 2,818,323 | 0.6% |
| Immatics N.V.(IMTX) | SHS | N44445109 | $51.7M | 7,275,830 | 0.6% |
| Crispr Therapeutics AG(CRSP) | NAMEN AKT | H17182108 | $51.5M | 1,308,011 | 0.5% |
| Stoke Therapeutics, Inc.(STOK) | COM | 86150R107 | $51.1M | 4,633,838 | 0.5% |
| Immunocore Holdings plc(IMCR) | ADS | 45258D105 | $44.7M | 1,515,318 | 0.5% |
| Roivant Sciences Ltd.(ROIV) | SHS | G76279101 | $44.6M | 3,767,773 | 0.5% |
| Sera Prognostics, Inc.(SERA) | CLASS A COM | 81749D107 | $44.2M | 5,434,399 | 0.5% |
| Immunovant, Inc.(IMVT) | COM | 45258J102 | $42.3M | 1,707,881 | 0.5% |
| Xenon Pharmaceuticals Inc.(XENE) | COM | 98420N105 | $39.0M | 993,679 | 0.4% |
| Celcuity Inc.(CELC) | COM | 15102K100 | $35.1M | 2,678,553 | 0.4% |
| Monte Rosa Therapeutics, Inc.(GLUE) | COM | 61225M102 | $34.1M | 4,916,095 | 0.4% |
| Akero Therapeutics, Inc.(AKRO) | COM | 00973Y108 | $30.5M | 1,097,082 | 0.3% |
| Cerus Corporation(CERS) | COM | 157085101 | $30.0M | 19,477,339 | 0.3% |
| Ionis Pharmaceuticals, Inc. | Note 1.75% 6/15/2028 | 462222AF7 | $29.5M | $30,000,000 | 0.3% |
| Grail, Inc.(GRAL) | COM | 384747101 | $29.1M | 1,630,125 | 0.3% |
| Ideaya Biosciences, Inc.(IDYA) | COM | 45166A102 | $27.3M | 1,062,123 | 0.3% |
| Krystal Biotech, Inc.(KRYS) | COM | 501147102 | $26.6M | 169,934 | 0.3% |
| Candel Therapeutics, Inc.(CADL) | COM | 137404109 | $25.9M | 2,981,983 | 0.3% |
| Praxis Precision Medicines, Inc.(PRAX) | COM | 74006W207 | $25.5M | 331,533 | 0.3% |
| IGM Biosciences, Inc.(1K0) | COM | 449585108 | $25.0M | 4,094,304 | 0.3% |
| Centessa Pharmaceuticals plc(CNTA) | SPONSORED ADS | 152309100 | $20.6M | 1,227,178 | 0.2% |
| Merus N.V. | COM | N5749R100 | $18.9M | 450,000 | 0.2% |
| Dyne Therapeutics, Inc.(DYN) | COM | 26818M108 | $15.8M | 672,096 | 0.2% |
| Neurogene Inc.(NGNE) | COM | 64135M105 | $15.4M | 674,450 | 0.2% |
| Xencor, Inc.(XNCR) | COM | 98401F105 | $15.4M | 670,431 | 0.2% |
| Bicara Therapeutics Inc.(BCAX) | COM | 055477103 | $14.5M | 833,333 | 0.2% |
| Prelude Therapeutics Inc.(PRLD) | COM | 74065P101 | $12.9M | 10,123,824 | 0.1% |
| Ionis Pharmaceuticals, Inc.(IONS) | COM | 462222100 | $12.5M | 357,915 | 0.1% |
| Alumis Inc.(ALMS) | COM | 022307102 | $12.3M | 1,562,500 | 0.1% |