Q4 2024 Holdings
Filed 2025-02-14 | 90 holdings | $7.5B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Ascendis Pharma A/S(ASND) | SH | 04351P101 | $1.4B | 10,112,744 | 18.5% |
| Vaxcyte Inc(PCVX) | SH | 92243G108 | $711.3M | 8,689,190 | 9.5% |
| Janux Therapeutics Inc(JANX) | SH | 47103J105 | $555.0M | 10,365,652 | 7.4% |
| Rhythm Pharmaceuticals Inc(RYTM) | SH | 76243J105 | $340.6M | 6,084,412 | 4.5% |
| Legend Biotech Corp(LEGN) | SH | 52490G102 | $244.3M | 7,506,934 | 3.3% |
| Edgewise Therapeutics Inc(EWTX) | SH | 28036F105 | $237.9M | 8,909,091 | 3.2% |
| Newamsterdam Pharma Co NV(NAMS) | SH | N62509109 | $227.3M | 8,845,000 | 3.0% |
| Wave Life Sciences LTD(WVE) | SH | Y95308105 | $225.2M | 18,202,009 | 3.0% |
| Arcellx Inc(ACLX) | SH | 03940C100 | $213.8M | 2,787,327 | 2.8% |
| Avidity Biosciences Inc(RNA) | SH | 05370A108 | $183.2M | 6,300,408 | 2.4% |
| Septerna Inc(SEPN) | SH | 81734D104 | $160.2M | 6,995,858 | 2.1% |
| Dyne Therapeutics Inc(DYN) | SH | 26818M108 | $150.3M | 6,381,144 | 2.0% |
| Tyra Biosciences Inc(TYRA) | SH | 90240B106 | $147.9M | 10,637,290 | 2.0% |
| Rxsight Inc(RXST) | SH | 78349D107 | $128.7M | 3,743,018 | 1.7% |
| Bicara Therapeutics Inc(BCAX) | SH | 055477103 | $121.2M | 6,955,993 | 1.6% |
| Lenz Therapeutics Inc(LENZ) | SH | 52635N103 | $120.6M | 4,178,823 | 1.6% |
| ARS Pharmaceuticals Inc(SPRY) | SH | 82835W108 | $114.6M | 10,860,977 | 1.5% |
| 89Bio Inc(ETNBGBP) | SH | 282559103 | $110.9M | 14,175,398 | 1.5% |
| Spdr S&P Biotech ETF(XBI) | SH | 78464A870 | $110.6M | 1,228,240 | 1.5% |
| Geron Corp(GERN) | SH | 374163103 | $106.2M | 30,009,536 | 1.4% |
| Artiva Biotherapeutics Inc(ARTV) | SH | 04317A107 | $99.3M | 9,853,302 | 1.3% |
| Axsome Therapeutics Inc(AXSM) | SH | 05464T104 | $84.6M | 1,000,000 | 1.1% |
| Verona Pharma PLC(VRNA) | SH | 925050106 | $82.1M | 1,766,830 | 1.1% |
| DAY One Biopharmaceuticals I(DAWN) | SH | 23954D109 | $72.9M | 5,755,577 | 1.0% |
| Apogee Therapeutics Inc(APGE) | SH | 03770N101 | $71.1M | 1,569,491 | 0.9% |
| Mineralys Therapeutics Inc(MLYS) | SH | 603170101 | $59.7M | 4,850,984 | 0.8% |
| Praxis Precision Medicines I(PRAX) | SH | 74006W207 | $58.6M | 761,955 | 0.8% |
| Climb BIO Inc(CLYM) | SH | 28658R106 | $56.6M | 31,419,267 | 0.8% |
| Recursion Pharmaceuticals(RXRX) | SH | 75629V104 | $52.2M | 7,725,096 | 0.7% |
| Tourmaline BIO Inc(TRML) | SH | 89157D105 | $51.5M | 2,538,925 | 0.7% |
| Acrivon Therapeutics Inc(ACRV) | SH | 004890109 | $50.2M | 8,340,508 | 0.7% |
| Fulcrum Therapeutics Inc(FULC) | SH | 359616109 | $48.1M | 10,229,099 | 0.6% |
| 10X Genomics Inc(TXG) | SH | 88025U109 | $47.1M | 3,279,401 | 0.6% |
| GH Research PLC(GHRS) | SH | G3855L106 | $46.8M | 6,686,689 | 0.6% |
| Astria Therapeutics Inc(CATBUSD) | SH | 04635X102 | $45.6M | 5,105,213 | 0.6% |
| VOR Biopharma Inc | SH | 929033108 | $44.0M | 39,646,039 | 0.6% |
| Structure Therapeutics Inc(GPCR) | SH | 86366E106 | $41.2M | 1,517,418 | 0.5% |
| Dianthus Therapeutics Inc(DNTH) | SH | 252828108 | $40.7M | 1,866,400 | 0.5% |
| Pepgen Inc(PEPG) | SH | 713317105 | $40.5M | 10,689,545 | 0.5% |
| Evolent Health Inc(EVH) | SH | 30050B101 | $40.2M | 3,577,197 | 0.5% |
| Kura Oncology Inc(KURA) | SH | 50127T109 | $38.8M | 4,451,041 | 0.5% |
| Ideaya Biosciences Inc(IDYA) | SH | 45166A102 | $34.6M | 1,347,252 | 0.5% |
| ZAI LAB LTD(ZLAB) | SH | 98887Q104 | $33.9M | 1,295,040 | 0.5% |
| Chimerix Inc(CMRXEUR) | SH | 16934W106 | $30.6M | 8,800,000 | 0.4% |
| Cidara Therapeutics Inc(CDTX) | SH | 171757206 | $29.4M | 1,092,796 | 0.4% |
| MBX Biosciences Inc(MBX) | SH | 55287L101 | $27.9M | 1,511,334 | 0.4% |
| Nkarta Inc(NKTX) | SH | 65487U108 | $26.9M | 10,805,129 | 0.4% |
| Acumen Pharmaceuticals Inc(ABOS) | SH | 00509G209 | $25.7M | 14,932,063 | 0.3% |
| 4D Molecular Therapeutics in(FDMT) | SH | 35104E100 | $25.4M | 4,563,211 | 0.3% |
| Nurix Therapeutics Inc(NRIX) | SH | 67080M103 | $25.1M | 1,333,333 | 0.3% |