Q1 2025 Holdings
Filed 2025-05-15 | 86 holdings | $6.0B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Ascendis Pharma A/S(ASND) | SH | 04351P101 | $1.6B | 10,281,496 | 26.8% |
| Vaxcyte Inc(PCVX) | SH | 92243G108 | $460.3M | 12,189,149 | 7.7% |
| Rhythm Pharmaceuticals Inc(RYTM) | SH | 76243J105 | $322.3M | 6,084,412 | 5.4% |
| Janux Therapeutics Inc(JANX) | SH | 47103J105 | $302.1M | 11,189,693 | 5.0% |
| Newamsterdam Pharma Co NV(NAMS) | SH | N62509109 | $207.5M | 10,138,938 | 3.5% |
| Arcellx Inc(ACLX) | SH | 03940C100 | $199.2M | 3,036,527 | 3.3% |
| Edgewise Therapeutics Inc(EWTX) | SH | 28036F105 | $196.0M | 8,909,091 | 3.3% |
| Avidity Biosciences Inc(RNA) | SH | 05370A108 | $186.0M | 6,300,408 | 3.1% |
| Wave Life Sciences LTD(WVE) | SH | Y95308105 | $147.1M | 18,202,009 | 2.5% |
| 89Bio Inc(ETNBGBP) | SH | 282559103 | $144.6M | 19,889,683 | 2.4% |
| ARS Pharmaceuticals Inc(SPRY) | SH | 82835W108 | $136.6M | 10,860,977 | 2.3% |
| Sionna Therapeutics Inc(SION) | SH | 829401108 | $109.3M | 10,445,322 | 1.8% |
| Lenz Therapeutics Inc(LENZ) | SH | 52635N103 | $107.4M | 4,178,823 | 1.8% |
| Dyne Therapeutics Inc(DYN) | SH | 26818M108 | $101.6M | 9,714,392 | 1.7% |
| Tyra Biosciences Inc(TYRA) | SH | 90240B106 | $98.9M | 10,637,290 | 1.7% |
| Mineralys Therapeutics Inc(MLYS) | SH | 603170101 | $97.6M | 6,147,280 | 1.6% |
| Geron Corp(GERN) | SH | 374163103 | $96.0M | 60,379,366 | 1.6% |
| Rxsight Inc(RXST) | SH | 78349D107 | $94.5M | 3,743,018 | 1.6% |
| Bicara Therapeutics Inc(BCAX) | SH | 055477103 | $90.6M | 6,955,993 | 1.5% |
| Disc Medicine Inc(IRON) | SH | 254604101 | $78.3M | 1,577,106 | 1.3% |
| GH Research PLC(GHRS) | SH | G3855L106 | $76.6M | 6,944,648 | 1.3% |
| Apogee Therapeutics Inc(APGE) | SH | 03770N101 | $58.6M | 1,569,491 | 1.0% |
| Dianthus Therapeutics Inc(DNTH) | SH | 252828108 | $52.0M | 2,866,733 | 0.9% |
| ZAI LAB LTD(ZLAB) | SH | 98887Q104 | $46.8M | 1,295,040 | 0.8% |
| DAY One Biopharmaceuticals I(DAWN) | SH | 23954D109 | $45.6M | 5,755,577 | 0.8% |
| Septerna Inc(SEPN) | SH | 81734D104 | $40.5M | 6,995,858 | 0.7% |
| Tourmaline BIO Inc(TRML) | SH | 89157D105 | $38.6M | 2,538,925 | 0.6% |
| Climb BIO Inc(CLYM) | SH | 28658R106 | $38.3M | 31,419,267 | 0.6% |
| Scholar Rock Holding Corp(SRRK) | SH | 80706P103 | $36.5M | 1,136,453 | 0.6% |
| Urogen Pharma LTD(URGN) | SH | M96088105 | $35.5M | 3,206,271 | 0.6% |
| Artiva Biotherapeutics Inc(ARTV) | SH | 04317A107 | $29.6M | 9,853,302 | 0.5% |
| Fulcrum Therapeutics Inc(FULC) | SH | 359616109 | $29.5M | 10,229,099 | 0.5% |
| VOR Biopharma Inc | SH | 929033108 | $28.4M | 39,646,039 | 0.5% |
| Astria Therapeutics Inc(CATBUSD) | SH | 04635X102 | $27.3M | 5,105,213 | 0.5% |
| Kura Oncology Inc(KURA) | SH | 50127T109 | $26.4M | 4,004,610 | 0.4% |
| Structure Therapeutics Inc(GPCR) | SH | 86366E106 | $26.3M | 1,517,418 | 0.4% |
| Cidara Therapeutics Inc(CDTX) | SH | 171757206 | $23.5M | 1,092,796 | 0.4% |
| Aerovate Therapeutics Inc | SH | 008064107 | $23.1M | 9,192,092 | 0.4% |
| Ideaya Biosciences Inc(IDYA) | SH | 45166A102 | $22.1M | 1,347,252 | 0.4% |
| Iteos Therapeutics Inc(5E7) | SH | 46565G104 | $21.8M | 3,649,057 | 0.4% |
| Travere Therapeutics Inc(TVTX) | SH | 89422G107 | $20.6M | 1,150,000 | 0.3% |
| Nkarta Inc(NKTX) | SH | 65487U108 | $19.9M | 10,805,129 | 0.3% |
| Glaukos Corp(GKOS) | SH | 377322102 | $18.7M | 190,256 | 0.3% |
| Monopar Therapeutics Inc(MNPR) | SH | 61023L207 | $18.6M | 511,207 | 0.3% |
| Metsera Inc | SH | 59267L107 | $18.4M | 675,525 | 0.3% |
| Eyepoint Pharmaceuticals Inc(EYPT) | SH | 30233G209 | $17.2M | 3,181,818 | 0.3% |
| 10X Genomics Inc(TXG) | SH | 88025U109 | $17.0M | 1,944,247 | 0.3% |
| Acrivon Therapeutics Inc(ACRV) | SH | 004890109 | $16.9M | 8,340,508 | 0.3% |
| Enliven Therapeutics Inc(ELVN) | SH | 29337E102 | $16.7M | 848,986 | 0.3% |
| Acumen Pharmaceuticals Inc(ABOS) | SH | 00509G209 | $16.4M | 14,932,063 | 0.3% |