Q3 2025 Holdings
Filed 2025-11-14 | 68 holdings | $8.1B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Ascendis Pharma A/S(ASND) | SH | 04351P101 | $2.0B | 10,281,496 | 25.2% |
| Rhythm Pharmaceuticals Inc(RYTM) | SH | 76243J105 | $573.8M | 5,681,359 | 7.1% |
| Vaxcyte Inc(PCVX) | SH | 92243G108 | $431.0M | 11,965,991 | 5.3% |
| Avidity Biosciences Inc(RNA) | SH | 05370A108 | $376.5M | 8,641,031 | 4.6% |
| Cidara Therapeutics Inc(CDTX) | SH | 171757206 | $322.3M | 3,365,523 | 4.0% |
| Sionna Therapeutics Inc(SION) | SH | 829401108 | $307.2M | 10,445,322 | 3.8% |
| 89Bio Inc(ETNBGBP) | SH | 282559103 | $292.4M | 19,889,683 | 3.6% |
| Newamsterdam Pharma Co NV(NAMS) | SH | N62509109 | $288.4M | 10,138,938 | 3.6% |
| Mineralys Therapeutics Inc(MLYS) | SH | 603170101 | $277.7M | 7,323,750 | 3.4% |
| Janux Therapeutics Inc(JANX) | SH | 47103J105 | $273.5M | 11,189,693 | 3.4% |
| Arcellx Inc(ACLX) | SH | 03940C100 | $249.3M | 3,036,527 | 3.1% |
| Lenz Therapeutics Inc(LENZ) | SH | 52635N103 | $194.6M | 4,178,823 | 2.4% |
| Tyra Biosciences Inc(TYRA) | SH | 90240B106 | $170.7M | 12,198,625 | 2.1% |
| Edgewise Therapeutics Inc(EWTX) | SH | 28036F105 | $169.1M | 10,428,437 | 2.1% |
| Wave Life Sciences LTD(WVE) | SH | Y95308105 | $133.2M | 18,202,009 | 1.6% |
| Septerna Inc(SEPN) | SH | 81734D104 | $131.6M | 6,995,858 | 1.6% |
| Dianthus Therapeutics Inc(DNTH) | SH | 252828108 | $112.8M | 2,866,733 | 1.4% |
| Bicara Therapeutics Inc(BCAX) | SH | 055477103 | $109.8M | 6,955,993 | 1.4% |
| GH Research PLC(GHRS) | SH | G3855L106 | $109.8M | 7,676,697 | 1.4% |
| ARS Pharmaceuticals Inc(SPRY) | SH | 82835W108 | $109.2M | 10,860,977 | 1.3% |
| Nuvalent Inc(NUVL) | SH | 670703107 | $107.8M | 1,246,456 | 1.3% |
| Disc Medicine Inc(IRON) | SH | 254604101 | $104.2M | 1,577,106 | 1.3% |
| VOR Biopharma Inc(VOR) | SH | 929033207 | $96.6M | 1,982,301 | 1.2% |
| Fulcrum Therapeutics Inc(FULC) | SH | 359616109 | $94.1M | 10,229,099 | 1.2% |
| Pepgen Inc(PEPG) | SH | 713317105 | $92.7M | 20,064,545 | 1.1% |
| Geron Corp(GERN) | SH | 374163103 | $82.7M | 60,379,366 | 1.0% |
| Taysha Gene Therapies Inc(TSHA) | SH | 877619106 | $77.0M | 23,555,648 | 0.9% |
| Belite BIO Inc(BLTE) | SH | 07782B104 | $64.8M | 875,000 | 0.8% |
| Climb BIO Inc(CLYM) | SH | 28658R106 | $63.2M | 31,419,267 | 0.8% |
| Scholar Rock Holding Corp(SRRK) | SH | 80706P103 | $43.5M | 1,166,788 | 0.5% |
| Structure Therapeutics Inc(GPCR) | SH | 86366E106 | $42.5M | 1,517,418 | 0.5% |
| Monopar Therapeutics Inc(MNPR) | SH | 61023L207 | $41.8M | 511,207 | 0.5% |
| 4D Molecular Therapeutics in(FDMT) | SH | 35104E100 | $39.7M | 4,563,211 | 0.5% |
| Solid Biosciences Inc(SLDB) | SH | 83422E204 | $35.9M | 5,811,423 | 0.4% |
| Metsera Inc | SH | 59267L107 | $35.4M | 675,525 | 0.4% |
| Artiva Biotherapeutics Inc(ARTV) | SH | 04317A107 | $28.3M | 9,853,302 | 0.3% |
| LB Pharmaceuticals Inc(LBRX) | SH | 50180M108 | $28.1M | 1,776,958 | 0.3% |
| Travere Therapeutics Inc(TVTX) | SH | 89422G107 | $27.5M | 1,150,000 | 0.3% |
| Assembly Biosciences Inc(ASMB) | SH | 045396207 | $26.1M | 1,020,410 | 0.3% |
| Acumen Pharmaceuticals Inc(ABOS) | SH | 00509G209 | $25.5M | 14,932,063 | 0.3% |
| Contineum Therapeutics Inc(CTNM) | SH | 21217B100 | $24.9M | 2,122,000 | 0.3% |
| Nkarta Inc(NKTX) | SH | 65487U108 | $22.4M | 10,805,129 | 0.3% |
| Larimar Therapeutics Inc(LRMR) | SH | 517125100 | $19.5M | 6,045,351 | 0.2% |
| Invivyd Inc(IVVD) | SH | 00534A102 | $18.8M | 17,119,096 | 0.2% |
| Tango Therapeutics Inc(TNGX) | SH | 87583X109 | $16.8M | 2,000,000 | 0.2% |
| Prime Medicine Inc(PRME) | SH | 74168J101 | $16.6M | 3,000,000 | 0.2% |
| Arcus Biosciences Inc(RCUS) | SH | 03969F109 | $15.5M | 1,136,364 | 0.2% |
| Acrivon Therapeutics Inc(ACRV) | SH | 004890109 | $15.1M | 8,340,508 | 0.2% |
| Werewolf Therapeutics Inc(HOWL) | SH | 95075A107 | $13.2M | 6,681,307 | 0.2% |
| Uniqure NV(QURE) | SH | N90064101 | $11.7M | 200,000 | 0.1% |