Q4 2022 Holdings
Filed 2023-02-14 | 77 holdings | $4.9B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Alnylam Pharmaceuticals Inc(ALNY) | COM | 02043Q107 | $400.1M | 1,683,362 | 8.2% |
| Prometheus Biosciences Inc | COM | 74349U108 | $369.0M | 3,354,303 | 7.5% |
| Rocket Pharmaceuticals Inc(RCKT) | COM | 77313F106 | $346.1M | 17,687,772 | 7.1% |
| Immunocore Hldgs PLC(IMCR) | ADS | 45258D105 | $317.3M | 5,559,322 | 6.5% |
| Thermo Fisher Scientific Inc(TMO) | COM | 883556102 | $239.8M | 435,500 | 4.9% |
| Axsome Therapeutics Inc(AXSM) | COM | 05464T104 | $229.9M | 2,980,482 | 4.7% |
| Masimo Corp(MASI) | COM | 574795100 | $222.1M | 1,501,493 | 4.5% |
| PTC Therapeutics Inc(PTCT) | COM | 69366J200 | $214.3M | 5,615,387 | 4.4% |
| Ultragenyx Pharmaceutical in(RARE) | COM | 90400D108 | $183.8M | 3,966,915 | 3.8% |
| Argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $182.7M | 482,195 | 3.7% |
| Mirati Therapeutics Inc(MRTXEUR) | COM | 60468T105 | $165.1M | 3,643,114 | 3.4% |
| Establishment Labs Hldgs Inc(ESTA) | COM | G31249108 | $155.9M | 2,374,138 | 3.2% |
| Penumbra Inc(PEN) | COM | 70975L107 | $155.4M | 698,371 | 3.2% |
| Celldex Therapeutics Inc New(CLDX) | COM NEW | 15117B202 | $137.5M | 3,084,215 | 2.8% |
| Avidity Biosciences Inc(RNA) | COM | 05370A108 | $124.4M | 5,605,566 | 2.5% |
| Cytokinetics Inc(CYTK) | COM NEW | 23282W605 | $117.9M | 2,574,198 | 2.4% |
| Illumina Inc(ILMN) | COM | 452327109 | $114.1M | 564,375 | 2.3% |
| Natera Inc(NTRA) | COM | 632307104 | $104.8M | 2,609,283 | 2.1% |
| Vericel Corp(VCEL) | COM | 92346J108 | $81.7M | 3,099,904 | 1.7% |
| Cutera Inc(CUTREUR) | COM | 232109108 | $79.5M | 1,798,675 | 1.6% |
| Acadia Pharmaceuticals Inc(ACAD) | COM | 004225108 | $58.4M | 3,670,938 | 1.2% |
| Globus MED Inc(GMED) | CL A | 379577208 | $55.5M | 747,685 | 1.1% |
| Axonics Inc(AXNX*) | COM | 05465P101 | $55.3M | 884,974 | 1.1% |
| Ventyx Biosciences Inc(VTYX) | COM | 92332V107 | $50.9M | 1,551,778 | 1.0% |
| Regenxbio Inc(RGNX) | COM | 75901B107 | $41.9M | 1,845,366 | 0.9% |
| Avadel Pharmaceuticals PLC | SPONSORED ADR | 05337M104 | $41.1M | 5,741,939 | 0.8% |
| Protagonist Therapeutics Inc(PTGX) | COM | 74366E102 | $39.2M | 3,591,986 | 0.8% |
| Adicet BIO Inc(TORCEUR) | COM | 007002108 | $37.9M | 4,241,472 | 0.8% |
| PMV Pharmaceuticals Inc(PMVP) | COM | 69353Y103 | $37.9M | 4,356,920 | 0.8% |
| Tarsus Pharmaceuticals Inc(TARS) | COM | 87650L103 | $37.4M | 2,548,125 | 0.8% |
| Bicycle Therapeutics PLC(BCYC) | SPONSORED ADS | 088786108 | $37.3M | 1,258,587 | 0.8% |
| Fulcrum Therapeutics Inc(FULC) | COM | 359616109 | $36.4M | 4,993,279 | 0.7% |
| Stoke Therapeutics Inc(STOK) | COM | 86150R107 | $35.7M | 3,870,981 | 0.7% |
| 10X Genomics Inc(TXG) | CL A COM | 88025U109 | $31.8M | 872,592 | 0.6% |
| Oyster PT Pharma Inc | COM | 69242L106 | $25.7M | 2,304,977 | 0.5% |
| Olink Hldg AB | SPONSORED ADS | 680710100 | $24.9M | 981,918 | 0.5% |
| Outset MED Inc(OMGBP) | COM | 690145107 | $23.5M | 909,652 | 0.5% |
| GH Research PLC(GHRS) | ORDINARY SHARES | G3855L106 | $21.1M | 2,168,957 | 0.4% |
| Iveric BIO Inc(OPHTEUR) | COM | 46583P102 | $17.6M | 821,288 | 0.4% |
| Milestone Pharmaceuticals in(MIST) | COM | 59935V107 | $17.1M | 4,315,102 | 0.3% |
| Cincor Pharma Inc | COM | 17240Y109 | $17.1M | 1,389,705 | 0.3% |
| C4 Therapeutics Inc(CCCC) | COM STK | 12529R107 | $16.6M | 2,819,472 | 0.3% |
| Allakos Inc(ALLKGUSD) | COM | 01671P100 | $13.8M | 1,643,500 | 0.3% |
| Castle Biosciences Inc(CSTL) | COM | 14843C105 | $12.2M | 516,995 | 0.2% |
| Guardant Health Inc(GH) | COM | 40131M109 | $11.7M | 430,887 | 0.2% |
| Terns Pharmaceuticals Inc(TERN) | COM | 880881107 | $10.2M | 1,000,000 | 0.2% |
| Health Sciences ACQ Corp 2 | ORD SHS | G4411D109 | $10.0M | 1,000,000 | 0.2% |
| Aadi Bioscience Inc(WHWK) | COM | 00032Q104 | $9.8M | 764,701 | 0.2% |
| Monte Rosa Therapeutics Inc(GLUE) | COM | 61225M102 | $9.2M | 1,214,572 | 0.2% |
| Sight Sciences Inc(SGHT) | COM | 82657M105 | $8.1M | 665,323 | 0.2% |