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Siren, L.L.C.

Q2 2026 Holdings

Filed 2026-08-13 | 119 holdings | $4.9B | 13F-HR | View on SEC ↗ · Holdings Table ↗

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IssuerClassCUSIPValue ↑Shares% Portfolio
enGene Therapeutics Inc(ENGN)COM29286X101$10.8M6,256,6620.2%
Adagene Inc(ADAG)ADS005329107$11.2M2,666,6660.2%
Inhibikase Therapeutics Inc(IKT)COM NEW45719W205$11.9M5,850,0000.2%
Generate Biomedicines Inc(GENB)COM SHS370920100$12.4M736,1040.3%
CytomX Therapeutics Inc(CTMX)COM23284F105$13.0M3,457,7110.3%
Microsoft Corp(MSFT)COM594918104$14.0M37,5000.3%
Nebius Group NV(NBIS)SHS CLASS AN97284108$14.4M52,0000.3%
Neumora Therapeutics Inc(NMRA)COM640979100$14.4M8,497,8220.3%
MapLight Therapeutics Inc(MPLT)COM56565P103$16.1M450,0000.3%
Rezolute Inc(RZLT)COM NEW76200L309$17.3M3,328,2870.4%
Nvidia Corp(NVDA)COM67066G104$19.0M95,0000.4%
Taiwan Semiconductor Manufacturing Co Ltd(TSM)SPONSORED ADS874039100$21.3M44,7000.4%
Zura Bio Ltd(ZURA)CLASS A ORD SHSG9TY5A101$22.0M3,734,8660.4%
Tyra Biosciences Inc(TYRA)COM90240B106$23.2M725,0000.5%
Damora Therapeutics Inc(GLTO)COM NEW36322Q206$23.4M900,0000.5%
Seaport Therapeutics Inc(SPTX)COMMON STOCK81221K108$23.8M1,095,3160.5%
Oruka Therapeutics Inc(ORKA)COM687604108$23.8M250,0000.5%
Monopar Therapeutics Inc(MNPR)COM NEW61023L207$25.0M270,1180.5%
Annexon Inc(ANNX)COM03589W102$25.5M4,458,6460.5%
Amylyx Pharmaceuticals Inc(AMLX)COM03237H101$26.6M1,480,5860.5%
Rapport Therapeutics Inc(RAPP)COM75383L102$26.7M641,4690.5%
Sionna Therapeutics Inc(SION)COM829401108$26.9M610,5150.5%
Absci Corp(ABSI)COM00091E109$28.7M2,474,7640.6%
Dbv Technologies SA(DBVT)SPONSORED ADS23306J309$30.5M1,857,3620.6%
Alphabet Inc(GOOGL)CAP STK CL A02079K305$32.2M90,0000.7%
Oric Pharmaceuticals Inc(ORIC)COM68622P109$32.5M2,998,1920.7%
Trevi Therapeutics Inc(TRVI)COM89532M101$33.3M1,786,8670.7%
Capital One Finl Corp(COF)COM14040H105$34.4M171,6150.7%
Cullinan Therapeutics Inc(CGEM)COM230031106$34.5M1,893,4100.7%
Remitly Global Inc(RELY)COM75960P104$34.6M1,543,2710.7%
Denali Therapeutics Inc(DNLI)COM24823R105$35.9M1,396,5130.7%
Silence Therapeutics PLC(SLN)ADS82686Q101$36.4M3,311,4380.7%
Palvella Therapeutics Inc(PVLA)COM697947109$39.3M257,4850.8%
Taboola.com Ltd(TBLA)ORD SHSM8744T106$42.1M8,423,4100.9%
Structure Therapeutics Inc(GPCR)SPONSORED ADS86366E106$46.9M872,9670.9%
Dyne Therapeutics, Inc(DYN)COM26818M108$47.3M2,129,1251.0%
Kailera Therapeutics Inc(KLRA)COMMON STOCK482931102$48.8M2,214,2861.0%
Crinetics Pharmaceuticals Inc(CRNX)COM22663K107$53.2M1,420,7881.1%
Olema Pharmaceuticals Inc(OLMA)COM68062P106$60.8M4,856,9491.2%
Septerna Inc(SEPN)COM81734D104$63.6M1,900,0001.3%
Cytokinetics Inc(CYTK)COM NEW23282W605$64.7M758,9521.3%
Disc Medicine Inc(IRON)COM254604101$65.0M888,4011.3%
Stoke Therapeutics Inc(STOK)COM86150R107$65.3M1,995,3471.3%
Definium Therapeutics Inc(DFTX)COM SHS24477V105$66.8M1,419,4931.4%
Taysha Gene Therapies Inc(TSHA)COM SHS877619106$67.1M9,846,5791.4%
Relay Therapeutics Inc(RLAY)COM75943R102$68.3M3,650,0001.4%
Cogent Biosciences Inc(COGT)COM19240Q201$72.0M1,859,2791.5%
Arcus Biosciences Inc(RCUS)COM03969F109$74.6M2,420,4301.5%
Hemab Therapeutics Holdings Inc(COAG)COM SHS423494103$76.6M2,086,8341.6%
Abivax SA(ABVX)SPONSORED ADS00370M103$76.8M576,0001.6%
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