Q4 2022 Holdings
Filed 2023-02-14 | 96 holdings | $3.6B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Amicus Therapeutics Inc(FOLD) | COM | 03152W109 | $337.5M | 27,642,917 | 9.5% |
| Amylyx Pharmaceuticals Inc(AMLX) | COM | 03237H101 | $225.0M | 6,088,333 | 6.3% |
| Madrigal Pharmaceuticals Inc(MDGL) | COM | 558868105 | $212.4M | 731,932 | 6.0% |
| Cerevel Therapeutics Hldng I(CERE1EUR) | COM | 15678U128 | $205.4M | 6,511,727 | 5.8% |
| Prometheus Biosciences Inc | COM | 74349U108 | $133.4M | 1,212,694 | 3.7% |
| Verona Pharma PLC(VRNA) | SPONSORED ADS | 925050106 | $127.5M | 4,880,719 | 3.6% |
| Horizon Therapeutics PUB L | SHS | G46188101 | $109.2M | 960,000 | 3.1% |
| Mirati Therapeutics Inc(MRTXEUR) | COM | 60468T105 | $99.3M | 2,191,425 | 2.8% |
| Lianbio | SPONSORED ADS | 53000N108 | $94.4M | 57,558,451 | 2.7% |
| Madrigal Pharmaceuticals Inc(MDGL)Put | COM | 558868105 | $87.1M | 300,000 | 2.4% |
| Sarepta Therapeutics Inc(SRPT) | COM | 803607100 | $84.1M | 649,250 | 2.4% |
| Inhibrx Inc(INBXUSD) | COM | 45720L107 | $81.7M | 3,313,783 | 2.3% |
| Arcellx Inc(ACLX) | COMMON STOCK | 03940C100 | $80.5M | 2,598,305 | 2.3% |
| Aldeyra Therapeutics Inc(ALDX) | COM | 01438T106 | $79.0M | 11,350,085 | 2.2% |
| Xenon Pharmaceuticals Inc(XENE) | COM | 98420N105 | $75.8M | 1,921,273 | 2.1% |
| Crinetics Pharmaceuticals in(CRNX) | COM | 22663K107 | $73.9M | 4,039,276 | 2.1% |
| Bellus Health Inc New(BLU) | COM NEW | 07987C204 | $73.1M | 8,891,027 | 2.1% |
| Springworks Therapeutics Inc | COM | 85205L107 | $68.1M | 2,617,691 | 1.9% |
| Nuvalent Inc(NUVL) | COM | 670703107 | $67.2M | 2,255,007 | 1.9% |
| Iovance Biotherapeutics Inc(IOVA) | COM | 462260100 | $63.7M | 9,971,780 | 1.8% |
| Vaxcyte Inc(PCVX) | COM | 92243G108 | $56.1M | 1,170,000 | 1.6% |
| Biomarin Pharmaceutical Inc(BMRN) | COM | 09061G101 | $52.4M | 506,481 | 1.5% |
| Adma Biologics Inc(ADMA) | COM | 000899104 | $46.2M | 11,900,255 | 1.3% |
| Meiragtx Hldgs PLC(MGTX) | COM | G59665102 | $45.4M | 6,963,277 | 1.3% |
| Treace Medical Concepts Inc(TMCI) | COM | 89455T109 | $44.7M | 1,946,403 | 1.3% |
| Veru Inc(VERUEUR) | COM | 92536C103 | $41.5M | 7,858,011 | 1.2% |
| Albireo Pharma Inc(BDQM) | COM | 01345P106 | $38.0M | 1,757,160 | 1.1% |
| Cogent Biosciences Inc(COGT) | COM | 19240Q201 | $37.1M | 3,207,441 | 1.0% |
| Viridian Therapeutics Inc(VRDN) | COM | 92790C104 | $35.7M | 1,220,575 | 1.0% |
| Rapt Therapeutics Inc(RAPTEUR) | COM | 75382E109 | $35.6M | 1,798,955 | 1.0% |
| Zymeworks del Inc(ZYME) | COM | 98985Y108 | $35.5M | 4,511,275 | 1.0% |
| Acrivon Therapeutics Inc(ACRV) | COMMON STOCK | 004890109 | $34.7M | 3,007,858 | 1.0% |
| Establishment Labs Hldgs Inc(ESTA) | COM | G31249108 | $32.7M | 497,857 | 0.9% |
| Astria Therapeutics Inc(CATBUSD) | COM | 04635X102 | $32.6M | 2,189,462 | 0.9% |
| Cincor Pharma Inc | COM | 17240Y109 | $31.7M | 2,576,325 | 0.9% |
| Immatics N.v(IMTX) | SHS | N44445109 | $30.4M | 3,491,500 | 0.9% |
| Relay Therapeutics Inc(RLAY) | COM | 75943R102 | $29.0M | 1,943,097 | 0.8% |
| Lyra Therapeutics Inc(LYRA) | COM | 55234L105 | $28.7M | 9,146,730 | 0.8% |
| Outset MED Inc(OMGBP) | COM | 690145107 | $28.1M | 1,089,427 | 0.8% |
| Harmony Biosciences Hldgs in(HRMY) | COM | 413197104 | $22.7M | 411,804 | 0.6% |
| Rocket Pharmaceuticals Inc(RCKT) | COM | 77313F106 | $21.1M | 1,078,204 | 0.6% |
| VBI Vaccines Inc CDA(VAC2USD) | COM NEW | 91822J103 | $20.4M | 52,335,002 | 0.6% |
| Rain Oncology Inc | COM | 75082Q105 | $19.9M | 2,483,619 | 0.6% |
| Akero Therapeutics Inc(AKRO) | COM | 00973Y108 | $19.2M | 350,525 | 0.5% |
| Tarsus Pharmaceuticals Inc(TARS) | COM | 87650L103 | $19.0M | 1,296,416 | 0.5% |
| Solid Biosciences Inc(SLDB) | COM NEW | 83422E204 | $18.8M | 3,495,933 | 0.5% |
| Nautilus Biotechnology Inc(NAUT) | COM | 63909J108 | $16.4M | 9,111,151 | 0.5% |
| Roivant Sciences LTD(ROIV) | SHS | G76279101 | $15.8M | 1,981,570 | 0.4% |
| Athira Pharma Inc | COM | 04746L104 | $15.2M | 4,797,278 | 0.4% |
| Prothena Corp PLC(PRTA) | SHS | G72800108 | $14.3M | 237,646 | 0.4% |