Q2 2025 Holdings
Filed 2025-08-14 | 30 holdings | $5.7B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Ascendis Pharma(ASND) | Sponsored ADR | 04351P101 | $859.5M | 4,980,000 | 15.1% |
| United Therapeutics Corp(UTHR) | Common | 91307C102 | $681.0M | 2,370,000 | 11.9% |
| Argenx SE(ARGX) | Sponsored ADR | 04016X101 | $647.7M | 1,175,000 | 11.3% |
| Madrigal Pharmaceuticals Inc(MDGL) | Common | 558868105 | $567.5M | 1,875,000 | 9.9% |
| Krystal Biotech Inc(KRYS) | Common | 501147102 | $365.6M | 2,660,000 | 6.4% |
| Kymera Therapeutics Inc(KYMR) | Common | 501575104 | $286.1M | 6,555,555 | 5.0% |
| Apellis Pharmaceuticals Inc.(APLS) | Common | 03753U106 | $211.6M | 12,222,222 | 3.7% |
| Avidity Biosciences Inc(RNA) | Common | 05370A108 | $200.2M | 7,050,000 | 3.5% |
| Moonlake Immunotherapeutics(MLTX) | CLASS A ORD | 61559X104 | $195.9M | 4,150,000 | 3.4% |
| Akero Therapeutics Inc(AKRO) | Common | 00973Y108 | $186.8M | 3,500,000 | 3.3% |
| Soleno Therapeutics Inc(SLNO) | Common | 834203309 | $171.7M | 2,050,000 | 3.0% |
| Xenon Pharmaceuticals Inc(XENE) | Common | 98420N105 | $169.0M | 5,400,000 | 3.0% |
| Arrowhead Pharmaceuticals Inc.(ARWR) | Common | 04280A100 | $167.5M | 10,600,000 | 2.9% |
| Merus N V | Common | N5749R100 | $166.0M | 3,155,555 | 2.9% |
| Vera Therapeutics Inc(VERA) | Common | 92337R101 | $148.4M | 6,300,000 | 2.6% |
| Amicus Therapeutics Inc.(FOLD) | Common | 03152W109 | $103.1M | 18,000,000 | 1.8% |
| Alkermes PLC(ALKS) | Common | G01767105 | $83.0M | 2,900,000 | 1.5% |
| Ocular Therapeutix Inc(OCUL) | Common | 67576A100 | $68.7M | 7,400,000 | 1.2% |
| 89Bio Inc(ETNBGBP) | Common | 282559103 | $66.3M | 6,750,000 | 1.2% |
| Centessa Pharmaceuticals PLC(CNTA) | SPONSORED ADR | 152309100 | $65.7M | 5,000,000 | 1.2% |
| Uniqure NV(QURE) | Common | N90064101 | $50.5M | 3,625,000 | 0.9% |
| Taysha Gene Therapies Inc(TSHA) | Common | 877619106 | $50.1M | 21,700,000 | 0.9% |
| Blueprint Medicines Corp(2L9) | Common | 09627Y109 | $48.1M | 375,000 | 0.8% |
| Tourmaline BIO Inc(TRML) | Common | 89157D105 | $40.9M | 2,555,555 | 0.7% |
| Biocryst Pharmaceuticals Inc(BCRX) | Common | 09058V103 | $40.3M | 4,500,000 | 0.7% |
| Mannkind Corp(MNKD) | Common | 56400P706 | $21.9M | 5,850,000 | 0.4% |
| Monte Rosa Therapeutics Inc(GLUE) | Common | 61225M102 | $16.8M | 3,725,000 | 0.3% |
| Septerna Inc(SEPN) | Common | 81734D104 | $13.1M | 1,237,500 | 0.2% |
| Ultragenyx Pharmaceutical Inc(RARE) | Common | 90400D108 | $12.0M | 330,000 | 0.2% |
| Whitehawk Therapeutics Inc(WHWK) | Common | 00032Q104 | $5.3M | 2,849,402 | 0.1% |