Q3 2025 Holdings
Filed 2025-11-14 | 32 holdings | $7.7B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Ascendis Pharma(ASND) | Sponsored ADR | 04351P101 | $1.0B | 5,110,000 | 13.1% |
| United Therapeutics Corp(UTHR) | Common | 91307C102 | $847.7M | 2,022,222 | 11.0% |
| Madrigal Pharmaceuticals Inc(MDGL) | Common | 558868105 | $840.7M | 1,833,000 | 10.9% |
| Argenx SE(ARGX) | Sponsored ADR | 04016X101 | $730.2M | 990,000 | 9.4% |
| Krystal Biotech Inc(KRYS) | Common | 501147102 | $490.4M | 2,777,777 | 6.3% |
| Arrowhead Pharmaceuticals Inc.(ARWR) | Common | 04280A100 | $375.9M | 10,900,000 | 4.9% |
| Kymera Therapeutics Inc(KYMR) | Common | 501575104 | $359.4M | 6,350,000 | 4.6% |
| Merus N V | Common | N5749R100 | $333.5M | 3,542,500 | 4.3% |
| Avidity Biosciences Inc(RNA) | Common | 05370A108 | $333.1M | 7,645,000 | 4.3% |
| Apellis Pharmaceuticals Inc.(APLS) | Common | 03753U106 | $276.6M | 12,222,222 | 3.6% |
| Centessa Pharmaceuticals PLC(CNTA) | SPONSORED ADR | 152309100 | $262.1M | 10,808,080 | 3.4% |
| Uniqure NV(QURE) | Common | N90064101 | $259.4M | 4,444,444 | 3.4% |
| Xenon Pharmaceuticals Inc(XENE) | Common | 98420N105 | $216.8M | 5,400,000 | 2.8% |
| Akero Therapeutics Inc(AKRO) | Common | 00973Y108 | $187.8M | 3,955,555 | 2.4% |
| Vera Therapeutics Inc(VERA) | Common | 92337R101 | $180.5M | 6,210,000 | 2.3% |
| Soleno Therapeutics Inc(SLNO) | Common | 834203309 | $174.3M | 2,577,777 | 2.3% |
| Structure Therapeutics Inc.(GPCR) | SPONSORED ADS | 86366E106 | $144.4M | 5,155,555 | 1.9% |
| Tourmaline BIO Inc(TRML) | Common | 89157D105 | $122.2M | 2,555,555 | 1.6% |
| Ocular Therapeutix Inc(OCUL) | Common | 67576A100 | $119.8M | 10,250,000 | 1.5% |
| Amicus Therapeutics Inc.(FOLD) | Common | 03152W109 | $118.4M | 15,025,000 | 1.5% |
| 89Bio Inc(ETNBGBP) | Common | 282559103 | $93.9M | 6,387,790 | 1.2% |
| Taysha Gene Therapies Inc(TSHA) | Common | 877619106 | $71.0M | 21,700,000 | 0.9% |
| Alkermes PLC(ALKS) | Common | G01767105 | $67.2M | 2,240,000 | 0.9% |
| Oruka Therapeutics Inc(ORKA) | Common | 687604108 | $25.6M | 1,333,340 | 0.3% |
| Septerna Inc(SEPN) | Common | 81734D104 | $25.2M | 1,337,500 | 0.3% |
| Mannkind Corp(MNKD) | Common | 56400P706 | $24.0M | 4,468,877 | 0.3% |
| Moonlake Immunotherapeutics(MLTX) | CLASS A ORD | 61559X104 | $14.3M | 2,000,000 | 0.2% |
| Biocryst Pharmaceuticals Inc(BCRX) | Common | 09058V103 | $9.5M | 1,250,000 | 0.1% |
| Whitehawk Therapeutics Inc(WHWK) | Common | 00032Q104 | $5.4M | 2,849,402 | 0.1% |
| Tango Therapeutics Inc(TNGX) | Common | 87583X109 | $4.6M | 545,000 | 0.1% |
| United Therapeutics Corp(UTHR)Call | Common | 91307C102 | $4.4M | 200,000 | 0.1% |
| Structure Therapeutics Inc.(GPCR)Call | SPONSORED ADS | 86366E106 | $2.2M | 250,000 | 0.0% |