Q4 2025 Holdings
Filed 2026-02-17 | 86 holdings | $17.1B | 13F-HR | View on SEC ↗ · Holdings Table ↗
Sign in to see sub-manager breakdown
| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Incyte Corporation(INCY) | COM | 45337C102 | $3.0B | 30,743,991 | 17.8% |
| BeOne Medicines Ltd.(ONC) | SPONSORED ADS | 07725L102 | $2.7B | 8,799,053 | 15.7% |
| Madrigal Pharmaceuticals, Inc.(MDGL) | COM | 558868105 | $1.2B | 2,141,701 | 7.3% |
| Insmed Incorporated(INSM) | COM PAR $.01 | 457669307 | $1.1B | 6,592,746 | 6.7% |
| Acadia Pharmaceuticals Inc.(ACAD) | COM | 004225108 | $1.1B | 42,896,690 | 6.7% |
| Celcuity Inc.(CELC) | COM | 15102K100 | $789.5M | 7,915,792 | 4.6% |
| Revolution Medicines, Inc.(RVMD) | COM | 76155X100 | $753.1M | 9,455,357 | 4.4% |
| Kymera Therapeutics, Inc.(KYMR) | COM | 501575104 | $673.6M | 8,657,242 | 3.9% |
| Summit Therapeutics Inc.(SMMT) | COM | 86627T108 | $636.5M | 36,391,063 | 3.7% |
| Rhythm Pharmaceuticals, Inc.(RYTM) | COM | 76243J105 | $599.9M | 5,604,483 | 3.5% |
| Kodiak Sciences Inc.(KOD) | COM | 50015M109 | $556.9M | 19,919,186 | 3.3% |
| Praxis Precision Medicines, Inc.(PRAX) | COM | 74006W207 | $332.0M | 1,126,488 | 1.9% |
| Alkermes plc(ALKS) | SHS | G01767105 | $280.1M | 10,012,267 | 1.6% |
| Grail, Inc.(GRAL) | COM | 384747101 | $178.5M | 2,085,333 | 1.0% |
| Edgewise Therapeutics, Inc.(EWTX) | COM | 28036F105 | $163.2M | 6,575,940 | 1.0% |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | COM | 04280A100 | $144.4M | 2,175,645 | 0.8% |
| Ionis Pharmaceuticals, Inc.(IONS) | COM | 462222100 | $141.8M | 1,791,841 | 0.8% |
| Immunovant, Inc.(IMVT) | COM | 45258J102 | $138.7M | 5,457,881 | 0.8% |
| Immatics N.V.(IMTX) | SHS | N44445109 | $127.0M | 12,094,094 | 0.7% |
| Ideaya Biosciences, Inc.(IDYA) | COM | 45166A102 | $125.1M | 3,618,826 | 0.7% |
| Roivant Sciences Ltd.(ROIV) | SHS | G76279101 | $120.5M | 5,555,017 | 0.7% |
| Abivax S.A.(ABVX) | SPONSORED ADS | 00370M103 | $118.1M | 875,796 | 0.7% |
| Kiniksa Pharmaceuticals International, plc(KNSA) | ORD SHS CL A | G52694109 | $116.6M | 2,826,246 | 0.7% |
| Replimune Group, Inc.(REPL) | COM | 76029N106 | $107.4M | 11,045,336 | 0.6% |
| Stoke Therapeutics, Inc.(STOK) | COM | 86150R107 | $105.9M | 3,336,697 | 0.6% |
| Structure Therapeutics Inc.(GPCR) | SPONSORED ADS | 86366E106 | $99.6M | 1,432,529 | 0.6% |
| AbCellera Biologics Inc.(ABCL) | COM | 00288U106 | $94.1M | 27,525,640 | 0.6% |
| Nurix Therapeutics, Inc.(NRIX) | COM | 67080M103 | $88.4M | 4,658,556 | 0.5% |
| Immunocore Holdings plc(IMCR) | ADS | 45258D105 | $80.6M | 2,322,656 | 0.5% |
| Bicycle Therapeutics plc(BCYC) | SPONSORED ADS | 088786108 | $77.1M | 10,885,357 | 0.5% |
| Crinetics Pharmaceuticals, Inc.(CRNX) | COM | 22663K107 | $76.8M | 1,648,869 | 0.4% |
| Monte Rosa Therapeutics, Inc.(GLUE) | COM | 61225M102 | $68.1M | 4,345,736 | 0.4% |
| Celcuity Inc. | Note 2.75% 8/1/2031 | 15102KAA8 | $66.6M | $30,750,000 | 0.4% |
| Ultragenyx Pharmaceutical Inc.(RARE) | COM | 90400D108 | $63.8M | 2,772,692 | 0.4% |
| Denali Therapeutics Inc.(DNLI) | COM | 24823R105 | $61.6M | 3,731,695 | 0.4% |
| Viridian Therapeutics, Inc.(VRDN) | COM | 92790C104 | $61.4M | 1,971,678 | 0.4% |
| Entrada Therapeutics, Inc.(TRDA) | COM | 29384C108 | $52.1M | 5,072,730 | 0.3% |
| Rapport Therapeutics, Inc.(RAPP) | COM | 75383L102 | $46.9M | 1,547,090 | 0.3% |
| Terns Pharmaceuticals, Inc.(TERN) | COM | 880881107 | $38.4M | 950,000 | 0.2% |
| BioNTech SE(BNTX) | SPONSORED ADS | 09075V102 | $35.1M | 368,923 | 0.2% |
| Spyre Therapeutics, Inc.(SYRE) | COM | 00773J202 | $32.8M | 1,000,000 | 0.2% |
| Dianthus Therapeutics, Inc.(DNTH) | COM | 252828108 | $32.5M | 789,759 | 0.2% |
| Prelude Therapeutics Inc.(PRLD) | COM | 74065P101 | $29.4M | 10,123,824 | 0.2% |
| DBV Technologies S.A.(DBVT) | SPONSORED ADS | 23306J309 | $28.0M | 1,461,425 | 0.2% |
| Disc Medicine, Inc.(IRON) | COM | 254604101 | $26.8M | 337,050 | 0.2% |
| Jade Biosciences, Inc.(JBIO) | COM | 008064206 | $25.3M | 1,641,137 | 0.1% |
| Taysha Gene Therapies, Inc.(TSHA) | COM SHS | 877619106 | $22.0M | 4,004,756 | 0.1% |
| BioCryst Pharmaceuticals, Inc.(BCRX) | COM | 09058V103 | $22.0M | 2,822,727 | 0.1% |
| Ventyx Biosciences, Inc.(VTYX) | COM | 92332V107 | $21.2M | 2,349,280 | 0.1% |
| argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $21.2M | 25,174 | 0.1% |