Q4 2025 Holdings
Filed 2026-02-17 | 108 holdings | $4.9B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Edgewise Therapeutics Inc(EWTX) | COM | 28036F105 | $385.1M | 15,518,492 | 7.9% |
| ELI Lilly & Co(LLY) | COM | 532457108 | $323.7M | 301,200 | 6.6% |
| Boston Scientific Corp(BSX) | COM | 101137107 | $230.7M | 2,419,300 | 4.7% |
| Sinovac Biotech LTD(SVA) | SHS | P8696W104 | $184.5M | 2,718,735 | 3.8% |
| Edwards Lifesciences Corp(EW) | COM | 28176E108 | $157.1M | 1,842,900 | 3.2% |
| Upstream BIO Inc(UPB) | COM | 91678A107 | $154.6M | 5,693,589 | 3.2% |
| Intuitive Surgical Inc(ISRG) | COM NEW | 46120E602 | $149.2M | 263,400 | 3.0% |
| Sionna Therapeutics Inc(SION) | COM | 829401108 | $146.5M | 3,561,655 | 3.0% |
| MBX Biosciences Inc(MBX) | COM | 55287L101 | $124.1M | 3,935,203 | 2.5% |
| Argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $122.8M | 146,000 | 2.5% |
| Enliven Therapeutics Inc(ELVN) | COM | 29337E102 | $122.6M | 7,959,538 | 2.5% |
| Alnylam Pharmaceuticals Inc(ALNY) | COM | 02043Q107 | $114.8M | 288,800 | 2.3% |
| Stryker Corporation(SYK) | COM | 863667101 | $114.2M | 325,000 | 2.3% |
| ARS Pharmaceuticals Inc(SPRY) | COM | 82835W108 | $96.6M | 8,288,510 | 2.0% |
| Terns Pharmaceuticals Inc(TERN) | COM | 880881107 | $87.0M | 2,153,300 | 1.8% |
| Disc Medicine Inc(IRON) | COM | 254604101 | $84.8M | 1,067,550 | 1.7% |
| Caris Life Sciences Inc(CAI) | COM | 142152107 | $84.1M | 3,116,011 | 1.7% |
| Natera Inc(NTRA) | COM | 632307104 | $83.8M | 365,800 | 1.7% |
| Compass Therapeutics Inc(CMPX) | COM | 20454B104 | $81.7M | 15,219,994 | 1.7% |
| Structure Therapeutics Inc(GPCR) | SPONSORED ADS | 86366E106 | $80.8M | 1,161,803 | 1.6% |
| Danaher Corporation(DHR) | COM | 235851102 | $68.6M | 299,800 | 1.4% |
| CG Oncology Inc(CGON) | COM | 156944100 | $63.0M | 1,516,550 | 1.3% |
| Apellis Pharmaceuticals Inc(APLS) | COM | 03753U106 | $61.0M | 2,429,868 | 1.2% |
| Arrivent Biopharma Inc(AVBP) | COM | 04272N102 | $60.9M | 3,027,328 | 1.2% |
| The Cigna Group(CI) | COM | 125523100 | $56.4M | 205,000 | 1.2% |
| Rapt Therapeutics Inc(RAPT) | COM NEW | 75382E208 | $55.6M | 1,642,891 | 1.1% |
| Corvus Pharmaceuticals Inc(CRVS) | COM | 221015100 | $55.2M | 7,165,006 | 1.1% |
| United Therapeutics Corp del(UTHR) | COM | 91307C102 | $51.3M | 105,200 | 1.0% |
| Abivax SA(ABVX) | SPONSORED ADS | 00370M103 | $49.6M | 367,900 | 1.0% |
| Roivant Sciences LTD(ROIV) | SHS | G76279101 | $47.5M | 2,190,907 | 1.0% |
| Crinetics Pharmaceuticals in(CRNX) | COM | 22663K107 | $46.5M | 999,000 | 0.9% |
| Axsome Therapeutics Inc(AXSM) | COM | 05464T104 | $46.2M | 253,121 | 0.9% |
| Eyepoint Inc(EYPT) | COM NEW | 30233G209 | $45.1M | 2,468,314 | 0.9% |
| Avidity Biosciences Inc(RNA) | COM | 05370A108 | $44.7M | 619,530 | 0.9% |
| Neurocrine Biosciences Inc(NBIX) | COM | 64125C109 | $44.6M | 314,240 | 0.9% |
| Dyne Therapeutics Inc(DYN) | COM | 26818M108 | $43.1M | 2,202,184 | 0.9% |
| Bristol-Myers Squibb Co(BMY) | COM | 110122108 | $41.8M | 775,000 | 0.9% |
| Pfizer Inc(PFE) | COM | 717081103 | $41.2M | 1,652,900 | 0.8% |
| Trevi Therapeutics Inc(TRVI) | COM | 89532M101 | $39.9M | 3,190,700 | 0.8% |
| Neuropace Inc(NPCE) | COM | 641288105 | $37.2M | 2,406,335 | 0.8% |
| Ascendis Pharma A/S(ASND) | SPONSORED ADR | 04351P101 | $36.7M | 171,977 | 0.7% |
| Exact Sciences Corp(EXAS) | COM | 30063P105 | $35.7M | 351,716 | 0.7% |
| Mineralys Therapeutics Inc(MLYS) | COM | 603170101 | $35.6M | 980,400 | 0.7% |
| Elevance Health Inc Formerly(ELV) | COM | 036752103 | $34.7M | 99,100 | 0.7% |
| Forte Biosciences Inc(FBRX) | COM NEW | 34962G208 | $32.6M | 1,196,955 | 0.7% |
| Prelude Therapeutics Inc(PRLD) | COM | 74065P101 | $31.6M | 10,909,256 | 0.6% |
| Cybin Inc(HELP) | COM NEW | 23256X407 | $31.4M | 3,840,500 | 0.6% |
| Oric Pharmaceuticals Inc(ORIC) | COM | 68622P109 | $29.8M | 3,641,756 | 0.6% |
| Krystal Biotech Inc(KRYS) | COM | 501147102 | $29.5M | 119,800 | 0.6% |
| Praxis Precision Medicines I(PRAX) | COM NEW | 74006W207 | $27.9M | 94,500 | 0.6% |