Q4 2025 Holdings
Filed 2026-02-17 | 76 holdings | $2.9B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Abivax SA(ABVX) | SPONSORED ADS | 00370M103 | $256.2M | 1,900,000 | 8.7% |
| Invesco QQQ Trust Series 1(QQQ)Put | UNIT SER 1 | 46090E103 | $215.0M | 350,000 | 7.3% |
| Arcellx Inc(ACLX) | COMMON STOCK | 03940C100 | $190.7M | 2,925,000 | 6.5% |
| Terns Pharmaceuticals Inc(TERN) | COM | 880881107 | $181.8M | 4,500,000 | 6.2% |
| BioMarin Pharmaceutical Inc(BMRN) | COM | 09061G101 | $178.3M | 3,000,000 | 6.1% |
| Globus Medical Inc(GMED) | CL A | 379577208 | $111.3M | 1,275,000 | 3.8% |
| Nurix Therapeutics Inc(NRIX) | COM | 67080M103 | $89.0M | 4,690,000 | 3.0% |
| Alcon AG(ALC) | ORD SHS | H01301128 | $87.1M | 1,105,000 | 3.0% |
| Dexcom Inc(DXCM) | COM | 252131107 | $84.6M | 1,275,000 | 2.9% |
| Merck & Co Inc(MRK) | COM | 58933Y105 | $81.6M | 775,000 | 2.8% |
| Taysha Gene Therapies Inc(TSHA) | COM SHS | 877619106 | $75.6M | 13,750,000 | 2.6% |
| Abbott Laboratories(ABT) | COM | 002824100 | $75.2M | 600,000 | 2.6% |
| Immatics NV(IMTX) | SHS | N44445109 | $64.3M | 6,125,000 | 2.2% |
| Tyra Biosciences Inc(TYRA) | COM | 90240B106 | $63.8M | 2,425,000 | 2.2% |
| Bicara Therapeutics Inc(BCAX) | COM | 055477103 | $60.2M | 3,575,000 | 2.0% |
| Arrowhead Pharmaceuticals Inc(ARWR) | COM | 04280A100 | $59.8M | 900,000 | 2.0% |
| Enliven Therapeutics Inc(ELVN) | COM | 29337E102 | $59.0M | 3,830,000 | 2.0% |
| Disc Medicine Inc(IRON) | COM | 254604101 | $58.4M | 735,000 | 2.0% |
| Jazz Pharmaceuticals PLC(JAZZ) | SHS USD | G50871105 | $49.3M | 290,000 | 1.7% |
| Day One Biopharmaceuticals Inc(DAWN) | COM | 23954D109 | $48.5M | 5,200,000 | 1.6% |
| Lexeo Therapeutics Inc(LXEO) | COM | 52886X107 | $44.4M | 4,475,000 | 1.5% |
| Alto Neuroscience Inc(ANRO) | COM SHS | 02157Q109 | $44.2M | 2,485,000 | 1.5% |
| Apogee Therapeutics Inc(APGE) | COM | 03770N101 | $41.5M | 550,000 | 1.4% |
| Olema Pharmaceuticals Inc(OLMA) | COM | 68062P106 | $41.3M | 1,650,000 | 1.4% |
| Axsome Therapeutics Inc(AXSM) | COM | 05464T104 | $38.4M | 210,000 | 1.3% |
| Ascendis Pharma A/S(ASND) | SPONSORED ADR | 04351P101 | $37.3M | 175,000 | 1.3% |
| Rapport Therapeutics Inc(RAPP) | COM | 75383L102 | $33.7M | 1,110,000 | 1.1% |
| Solid Biosciences Inc(SLDB) | COM NEW | 83422E204 | $32.8M | 5,815,000 | 1.1% |
| Celldex Therapeutics Inc(CLDX) | COM NEW | 15117B202 | $31.6M | 1,165,000 | 1.1% |
| Scholar Rock Holding Corp(SRRK) | COM | 80706P103 | $30.8M | 700,000 | 1.0% |
| KalVista Pharmaceuticals Inc(KALV) | COM | 483497103 | $30.5M | 1,890,000 | 1.0% |
| Vera Therapeutics Inc(VERA) | CL A | 92337R101 | $27.9M | 550,000 | 0.9% |
| Xenon Pharmaceuticals Inc(XENE) | COM | 98420N105 | $26.9M | 600,000 | 0.9% |
| Lantheus Holdings Inc(LNTH) | COM | 516544103 | $24.0M | 360,000 | 0.8% |
| Revolution Medicines Inc(RVMD) | COM | 76155X100 | $23.5M | 295,000 | 0.8% |
| Zymeworks Inc(ZYME) | COM | 98985Y108 | $22.8M | 865,000 | 0.8% |
| Immunocore Holdings PLC(IMCR) | ADS | 45258D105 | $20.3M | 585,000 | 0.7% |
| Upstream Bio Inc(UPB) | COM | 91678A107 | $19.5M | 720,000 | 0.7% |
| Beta Bionics Inc(BBNX) | COM | 08659B102 | $18.3M | 600,000 | 0.6% |
| Crescent Biopharma Inc(CBIO) | COM | G2545C104 | $17.8M | 1,500,000 | 0.6% |
| BioCryst Pharmaceuticals Inc(BCRX) | COM | 09058V103 | $17.6M | 2,250,000 | 0.6% |
| Penumbra Inc(PEN) | COM | 70975L107 | $15.5M | 50,000 | 0.5% |
| Geron Corp(GERN) | COM | 374163103 | $14.9M | 11,320,000 | 0.5% |
| Repligen Corp(RGEN) | COM | 759916109 | $13.6M | 83,000 | 0.5% |
| Zimmer Biomet Holdings Inc(ZBH) | COM | 98956P102 | $13.5M | 150,000 | 0.5% |
| Bristol-Myers Squibb Co(BMY) | COM | 110122108 | $13.5M | 250,000 | 0.5% |
| Monte Rosa Therapeutics Inc(GLUE) | COM | 61225M102 | $12.2M | 775,000 | 0.4% |
| Fulcrum Therapeutics Inc(FULC) | COM | 359616109 | $10.7M | 950,000 | 0.4% |
| Savara Inc(SVRA) | COM | 805111101 | $9.7M | 1,606,000 | 0.3% |
| Engene Holdings Inc(ENGN) | COM | 29286M105 | $9.5M | 1,055,000 | 0.3% |