Q1 2025 Holdings
Filed 2025-08-06 | 87 holdings | $2.8B | 13F-HR/A | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Verona Pharma PLC(VRNA) | SPONSORED ADS | 925050106 | $416.7M | 6,563,340 | 14.7% |
| Arcellx Inc(ACLX) | COMMON STOCK | 03940C100 | $192.0M | 2,926,478 | 6.8% |
| Amicus Therapeutics Inc(FOLD) | COM | 03152W109 | $175.2M | 21,464,527 | 6.2% |
| Edgewise Therapeutics Inc(EWTX) | COM | 28036F105 | $144.0M | 6,547,328 | 5.1% |
| Rhythm Pharmaceuticals Inc(RYTM) | COM | 76243J105 | $135.0M | 2,548,445 | 4.8% |
| Nuvalent Inc(NUVL) | COM | 670703107 | $115.9M | 1,633,968 | 4.1% |
| Soleno Therapeutics Inc(SLNO) | COM | 834203309 | $107.6M | 1,506,602 | 3.8% |
| Intra-Cellular Therapies Inc(ITCIEUR) | COM | 46116X101 | $103.7M | 786,358 | 3.7% |
| Meiragtx Hldgs PLC(MGTX) | COM | G59665102 | $85.3M | 12,581,103 | 3.0% |
| Artivion Inc(AORT) | COM | 228903100 | $68.7M | 2,793,703 | 2.4% |
| Aldeyra Therapeutics Inc(ALDX) | COM | 01438T106 | $53.3M | 9,275,851 | 1.9% |
| Protagonist Therapeutics Inc(PTGX) | COM | 74366E102 | $52.8M | 1,091,271 | 1.9% |
| Evolus Inc(EOLS) | COM | 30052C107 | $49.7M | 4,129,142 | 1.8% |
| Immunovant Inc(IMVT) | COM | 45258J102 | $48.6M | 2,844,072 | 1.7% |
| Solid Biosciences Inc(SLDB) | COM NEW | 83422E204 | $44.1M | 11,906,646 | 1.6% |
| Centessa Pharmaceuticals PLC(CNTA) | SPONSORED ADS | 152309100 | $43.7M | 3,040,395 | 1.5% |
| Iovance Biotherapeutics Inc(IOVA) | COM | 462260100 | $42.3M | 12,711,788 | 1.5% |
| Immatics N.v(IMTX) | SHS | N44445109 | $42.3M | 9,383,456 | 1.5% |
| Apogee Therapeutics Inc(APGE) | COM | 03770N101 | $41.9M | 1,122,767 | 1.5% |
| Axsome Therapeutics Inc(AXSM) | COM | 05464T104 | $41.4M | 355,107 | 1.5% |
| Insmed Inc(INSM) | COM PAR $.01 | 457669307 | $38.9M | 509,300 | 1.4% |
| Spyre Therapeutics Inc(SYRE) | COM NEW | 00773J202 | $37.3M | 2,313,272 | 1.3% |
| Praxis Precision Medicines I(PRAX) | COM NEW | 74006W207 | $37.1M | 980,894 | 1.3% |
| Argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $35.2M | 59,510 | 1.2% |
| Astria Therapeutics Inc(CATBUSD) | COM | 04635X102 | $34.6M | 6,485,420 | 1.2% |
| Akero Therapeutics Inc(AKRO) | COM | 00973Y108 | $32.1M | 792,960 | 1.1% |
| Merus N V | COM | N5749R100 | $29.1M | 690,485 | 1.0% |
| Amylyx Pharmaceuticals Inc(AMLX) | COM | 03237H101 | $27.9M | 7,874,348 | 1.0% |
| Adma Biologics Inc(ADMA) | COM | 000899104 | $27.2M | 1,373,233 | 1.0% |
| Vaxcyte Inc(PCVX) | COM | 92243G108 | $26.7M | 706,567 | 0.9% |
| Janux Therapeutics Inc(JANX) | COM | 47103J105 | $26.2M | 970,412 | 0.9% |
| Dyne Therapeutics Inc(DYN) | COM | 26818M108 | $24.2M | 2,313,403 | 0.9% |
| Celcuity Inc(CELC) | COM | 15102K100 | $23.9M | 2,362,279 | 0.8% |
| Zymeworks Inc(ZYME) | COM | 98985Y108 | $22.2M | 1,864,672 | 0.8% |
| Intuitive Surgical Inc(ISRG) | COM NEW | 46120E602 | $20.1M | 40,619 | 0.7% |
| Orchestra Biomed Hldgs Inc(OBIO) | COM | 68572M106 | $19.7M | 4,592,556 | 0.7% |
| Beta Bionics Inc(BBNX) | COM | 08659B102 | $19.5M | 1,593,608 | 0.7% |
| Insulet Corp(PODD) | COM | 45784P101 | $18.8M | 71,597 | 0.7% |
| Repligen Corp(RGEN) | COM | 759916109 | $16.5M | 129,801 | 0.6% |
| Bright Minds Biosciences Inc(DRUG) | COM NEW | 10919W405 | $16.0M | 444,649 | 0.6% |
| Madrigal Pharmaceuticals Inc(MDGL) | COM | 558868105 | $15.4M | 46,500 | 0.5% |
| Inhibrx Biosciences Inc(INBX) | COM | 45720N103 | $14.9M | 1,064,026 | 0.5% |
| Boston Scientific Corp(BSX) | COM | 101137107 | $13.1M | 130,000 | 0.5% |
| Sionna Therapeutics Inc(SION) | COM | 829401108 | $13.1M | 1,251,101 | 0.5% |
| Inhibikase Therapeutics Inc(IKT) | COM NEW | 45719W205 | $13.0M | 5,925,000 | 0.5% |
| Viking Therapeutics Inc(VKTX) | COM | 92686J106 | $12.3M | 509,005 | 0.4% |
| Dexcom Inc(DXCM) | COM | 252131107 | $12.2M | 178,000 | 0.4% |
| Neurocrine Biosciences(NBIX) | COM | 64125C109 | $11.1M | 100,050 | 0.4% |
| Edgewise Therapeutics Inc(EWTX)Call | COM | 28036F105 | $11.0M | 500,000 | 0.4% |
| Xenon Pharmaceuticals Inc(XENE) | COM | 98420N105 | $10.9M | 325,324 | 0.4% |