Q3 2025 Holdings
Filed 2025-11-14 | 93 holdings | $3.5B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Rhythm Pharmaceuticals Inc(RYTM) | COM | 76243J105 | $288.4M | $419,104,969 | 8.3% |
| Ascendis Pharma A/S(ASND) | SPONSORED ADR | 04351P101 | $216.4M | 1,088,501 | 6.2% |
| Arcellx Inc(ACLX) | COMMON STOCK | 03940C100 | $202.7M | 2,468,353 | 5.9% |
| Celcuity Inc(CELC) | COM | 15102K100 | $146.0M | 2,956,319 | 4.2% |
| Nuvalent Inc(NUVL) | COM | 670703107 | $135.1M | 1,562,336 | 3.9% |
| Merus N V | COM | N5749R100 | $127.4M | 1,353,093 | 3.7% |
| Amylyx Pharmaceuticals Inc(AMLX) | COM | 03237H101 | $121.7M | 8,952,365 | 3.5% |
| Roivant Sciences LTD(ROIV) | SHS | G76279101 | $111.5M | 7,368,461 | 3.2% |
| Meiragtx Hldgs PLC(MGTX) | COM | G59665102 | $103.8M | 12,626,103 | 3.0% |
| Insmed Inc(INSM) | COM PAR $.01 | 457669307 | $101.1M | 702,130 | 2.9% |
| Travere Therapeutics Inc(TVTX) | COM | 89422G107 | $90.7M | 3,794,615 | 2.6% |
| Artivion Inc(AORT) | COM | 228903100 | $85.5M | 2,020,000 | 2.5% |
| Praxis Precision Medicines I(PRAX) | COM NEW | 74006W207 | $82.9M | 1,564,554 | 2.4% |
| Immatics N.v(IMTX) | SHS | N44445109 | $79.9M | 9,383,456 | 2.3% |
| Centessa Pharmaceuticals PLC(CNTA) | SPONSORED ADS | 152309100 | $75.2M | 3,100,902 | 2.2% |
| Solid Biosciences Inc(SLDB) | COM NEW | 83422E204 | $73.0M | 11,833,539 | 2.1% |
| Protagonist Therapeutics Inc(PTGX) | COM | 74366E102 | $68.4M | 1,030,134 | 2.0% |
| Neurocrine Biosciences Inc(NBIX) | COM | 64125C109 | $63.2M | 450,050 | 1.8% |
| Edgewise Therapeutics Inc(EWTX) | COM | 28036F105 | $61.6M | 3,795,894 | 1.8% |
| Verona Pharma PLC(VRNA) | SPONSORED ADS | 925050106 | $55.9M | 524,088 | 1.6% |
| Penumbra Inc(PEN) | COM | 70975L107 | $55.9M | 220,547 | 1.6% |
| Akero Therapeutics Inc(AKRO) | COM | 00973Y108 | $53.9M | 1,135,766 | 1.6% |
| Apogee Therapeutics Inc(APGE) | COM | 03770N101 | $53.7M | 1,351,989 | 1.6% |
| Omada Health Inc(OMDA) | COM | 68170A108 | $53.0M | 2,396,330 | 1.5% |
| Amicus Therapeutics Inc(FOLD) | COM | 03152W109 | $50.2M | 6,370,851 | 1.4% |
| Astria Therapeutics Inc(CATBUSD) | COM | 04635X102 | $47.2M | 6,485,420 | 1.4% |
| Inhibrx Biosciences Inc(INBX) | COM | 45720N103 | $44.7M | 1,327,707 | 1.3% |
| Repligen Corp(RGEN) | COM | 759916109 | $36.1M | 270,428 | 1.0% |
| Zymeworks Inc(ZYME) | COM | 98985Y108 | $35.7M | 2,090,663 | 1.0% |
| Sionna Therapeutics Inc(SION) | COM | 829401108 | $34.7M | 1,179,098 | 1.0% |
| Caris Life Sciences Inc(CAI) | COM | 142152107 | $33.2M | 1,098,163 | 1.0% |
| Abivax SA(ABVX) | SPONSORED ADS | 00370M103 | $33.0M | 388,608 | 1.0% |
| Viridian Therapeutics Inc(VRDN) | COM | 92790C104 | $31.6M | 1,462,400 | 0.9% |
| Cytomx Therapeutics Inc(CTMX) | COM | 23284F105 | $30.9M | 9,680,185 | 0.9% |
| Boston Scientific Corp(BSX) | COM | 101137107 | $30.3M | 310,000 | 0.9% |
| Aldeyra Therapeutics Inc(ALDX) | COM | 01438T106 | $27.3M | 5,222,311 | 0.8% |
| Bright Minds Biosciences Inc(DRUG) | COM NEW | 10919W405 | $27.3M | 449,290 | 0.8% |
| Immunovant Inc(IMVT) | COM | 45258J102 | $25.6M | 1,587,890 | 0.7% |
| Exact Sciences Corp(EXAS) | COM | 30063P105 | $25.5M | 465,487 | 0.7% |
| Palvella Therapeutics Inc NE(PVLA) | COM | 697947109 | $24.8M | 395,093 | 0.7% |
| Oruka Therapeutics Inc(ORKA) | COM | 687604108 | $24.4M | 1,268,021 | 0.7% |
| Intuitive Surgical Inc(ISRG) | COM NEW | 46120E602 | $23.3M | 52,119 | 0.7% |
| Irhythm Technologies Inc(IRTC) | COM | 450056106 | $21.2M | 123,000 | 0.6% |
| Aquestive Therapeutics Inc(AQST) | COM | 03843E104 | $21.0M | 3,760,099 | 0.6% |
| Spyre Therapeutics Inc(SYRE) | COM NEW | 00773J202 | $20.6M | 1,229,445 | 0.6% |
| Adagio MED Hldgs Inc(ADGM) | COM | 00534B100 | $19.2M | 9,876,576 | 0.6% |
| Axsome Therapeutics Inc(AXSM) | COM | 05464T104 | $18.1M | 148,900 | 0.5% |
| Adma Biologics Inc(ADMA) | COM | 000899104 | $16.9M | 1,153,468 | 0.5% |
| Engene Holdings Inc(ENGN) | COM | 29286M105 | $14.3M | 2,097,236 | 0.4% |
| Orchestra Biomed Hldgs Inc(OBIO) | COM | 68572M106 | $13.1M | 5,292,556 | 0.4% |