Q4 2025 Holdings
Filed 2026-02-17 | 116 holdings | $5.6B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Praxis Precision Medicines I(PRAX) | COM NEW | 74006W207 | $588.3M | 1,995,986 | 10.5% |
| Celcuity Inc(CELC) | COM | 15102K100 | $315.2M | 3,160,200 | 5.6% |
| Rhythm Pharmaceuticals Inc(RYTM) | COM | 76243J105 | $272.6M | 2,546,391 | 4.9% |
| Ascendis Pharma A/S(ASND) | SPONSORED ADR | 04351P101 | $230.6M | 1,081,421 | 4.1% |
| Apogee Therapeutics Inc(APGE) | COM | 03770N101 | $175.9M | 2,330,651 | 3.1% |
| Roivant Sciences LTD(ROIV) | SHS | G76279101 | $173.3M | 7,985,461 | 3.1% |
| Nuvalent Inc(NUVL) | COM | 670703107 | $167.5M | 1,665,105 | 3.0% |
| Travere Therapeutics Inc(TVTX) | COM | 89422G107 | $163.5M | 4,278,180 | 2.9% |
| Spdr Series Trust(XBI)Put | STATE STREET SPD | 78464A870 | $134.1M | 1,100,000 | 2.4% |
| Exact Sciences Corp(EXAS) | COM | 30063P105 | $121.9M | 1,200,487 | 2.2% |
| Protagonist Therapeutics Inc(PTGX) | COM | 74366E102 | $117.9M | 1,350,425 | 2.1% |
| Inhibrx Biosciences Inc(INBX) | COM | 45720N103 | $114.8M | 1,452,707 | 2.0% |
| Edgewise Therapeutics(EWTX) | COM | 28036F105 | $110.6M | 4,457,974 | 2.0% |
| Immatics N.v(IMTX) | SHS | N44445109 | $109.0M | 10,383,456 | 1.9% |
| Spyre Therapeutics Inc(SYRE) | COM NEW | 00773J202 | $100.5M | 3,069,225 | 1.8% |
| Amylyx Pharmaceuticals Inc(AMLX) | COM | 03237H101 | $100.1M | 8,284,882 | 1.8% |
| Arcellx Inc(ACLX) | COMMON STOCK | 03940C100 | $95.6M | 1,466,071 | 1.7% |
| Viridian Therapeutics Inc(VRDN) | COM | 92790C104 | $94.7M | 3,042,703 | 1.7% |
| Boston Scientific Corp(BSX) | COM | 101137107 | $93.3M | 979,000 | 1.7% |
| Amicus Therapeutics Inc(FOLD) | COM | 03152W109 | $90.7M | 6,370,851 | 1.6% |
| Zymeworks Inc(ZYME) | COM | 98985Y108 | $85.9M | 3,261,850 | 1.5% |
| Astria Therapeutics Inc(CATBUSD) | COM | 04635X102 | $84.9M | 6,485,420 | 1.5% |
| Meiragtx Hldgs PLC(MGTX) | COM | G59665102 | $82.1M | 10,326,103 | 1.5% |
| Artivion Inc(AORT) | COM | 228903100 | $78.6M | 1,722,290 | 1.4% |
| Centessa Pharmaceuticals PLC(CNTA) | SPONSORED ADS | 152309100 | $73.0M | 2,917,634 | 1.3% |
| Dyne Therapeutics Inc(DYN) | COM | 26818M108 | $68.0M | 3,478,944 | 1.2% |
| Nurix Therapeutics Inc(NRIX) | COM | 67080M103 | $67.5M | 3,555,877 | 1.2% |
| Solid Biosciences Inc(SLDB) | COM NEW | 83422E204 | $66.7M | 11,833,539 | 1.2% |
| Belite BIO Inc(BLTE) | SPONSORED ADS | 07782B104 | $66.3M | 414,239 | 1.2% |
| Abivax SA(ABVX) | SPONSORED ADS | 00370M103 | $61.8M | 458,343 | 1.1% |
| Invivyd Inc(IVVD) | COM | 00534A102 | $53.8M | 21,785,166 | 1.0% |
| Engene Holdings Inc(ENGN) | COM | 29286M105 | $53.0M | 5,869,076 | 0.9% |
| Repligen Corp(RGEN) | COM | 759916109 | $51.7M | 315,541 | 0.9% |
| Immunovant Inc(IMVT) | COM | 45258J102 | $50.7M | 1,994,890 | 0.9% |
| Intuitive Surgical Inc(ISRG) | COM NEW | 46120E602 | $49.8M | 87,919 | 0.9% |
| Sionna Therapeutics Inc(SION) | COM | 829401108 | $48.5M | 1,179,098 | 0.9% |
| Neurocrine Biosciences Inc(NBIX) | COM | 64125C109 | $47.0M | 331,050 | 0.8% |
| Danaher Corporation(DHR) | COM | 235851102 | $45.8M | 200,000 | 0.8% |
| Oruka Therapeutics Inc(ORKA) | COM | 687604108 | $44.8M | 1,476,501 | 0.8% |
| Cytomx Therapeutics Inc(CTMX) | COM | 23284F105 | $41.2M | 9,680,185 | 0.7% |
| Omada Health Inc(OMDA) | COM | 68170A108 | $37.8M | 2,396,330 | 0.7% |
| Cidara Therapeutics Inc(CDTX) | COM NEW | 171757206 | $36.5M | 165,131 | 0.7% |
| Disc Medicine Inc(IRON) | COM | 254604101 | $35.8M | 450,743 | 0.6% |
| Bright Minds Biosciences Inc(DRUG) | COM NEW | 10919W405 | $35.1M | 449,290 | 0.6% |
| Penumbra Inc(PEN) | COM | 70975L107 | $34.4M | 110,529 | 0.6% |
| Alto Neuroscience Inc(ANRO) | COM SHS | 02157Q109 | $31.8M | 1,784,393 | 0.6% |
| Caris Life Sciences Inc(CAI) | COM | 142152107 | $30.7M | 1,136,206 | 0.5% |
| Jazz Pharmaceuticals PLC(JAZZ) | SHS USD | G50871105 | $28.9M | 170,000 | 0.5% |
| Palisade BIO Inc(PALI) | COM | 696389402 | $28.3M | 12,050,000 | 0.5% |
| Rapt Therapeutics Inc(RAPT) | COM NEW | 75382E208 | $28.0M | 825,890 | 0.5% |