Q2 2025 Holdings
Filed 2025-08-14 | 73 holdings | $7.0B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Madrigal Pharmaceuticals Inc(MDGL) | COM | 558868105 | $603.4M | 1,993,687 | 8.6% |
| Natera Inc(NTRA) | COM | 632307104 | $438.2M | 2,593,645 | 6.2% |
| PTC Therapeutics Inc(PTCT) | COM | 69366J200 | $378.3M | 7,746,415 | 5.4% |
| Argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $371.2M | 673,497 | 5.3% |
| Protagonist Therapeutics Inc(PTGX) | COM | 74366E102 | $318.1M | 5,756,277 | 4.5% |
| Insmed Inc(INSM) | COM PAR $.01 | 457669307 | $310.4M | 3,084,558 | 4.4% |
| Akero Therapeutics Inc(AKRO) | COM | 00973Y108 | $292.3M | 5,477,561 | 4.2% |
| Verona Pharma PLC(VRNA) | SPONSORED ADS | 925050106 | $288.6M | 3,051,878 | 4.1% |
| Avidity Biosciences Inc(RNA) | COM | 05370A108 | $273.2M | 9,618,845 | 3.9% |
| Stryker Corporation(SYK) | COM | 863667101 | $233.6M | 590,517 | 3.3% |
| Penumbra Inc(PEN) | COM | 70975L107 | $221.6M | 863,553 | 3.2% |
| Merus N V | COM | N5749R100 | $210.4M | 4,000,553 | 3.0% |
| Acadia Pharmaceuticals Inc(ACAD) | COM | 004225108 | $194.0M | 8,995,547 | 2.8% |
| ZAI LAB LTD(ZLAB) | ADR | 98887Q104 | $193.6M | 5,536,876 | 2.8% |
| Axsome Therapeutics Inc(AXSM) | COM | 05464T104 | $158.3M | 1,516,903 | 2.3% |
| Radnet Inc(RDNT) | COM | 750491102 | $153.1M | 2,690,344 | 2.2% |
| Immunocore Hldgs PLC(IMCR) | ADS | 45258D105 | $152.8M | 4,869,798 | 2.2% |
| Alkermes PLC(ALKS) | SHS | G01767105 | $134.0M | 4,682,289 | 1.9% |
| Neurocrine Biosciences Inc(NBIX) | COM | 64125C109 | $133.5M | 1,062,072 | 1.9% |
| Tarsus Pharmaceuticals Inc(TARS) | COM | 87650L103 | $126.1M | 3,111,680 | 1.8% |
| Apogee Therapeutics Inc(APGE) | COM | 03770N101 | $117.8M | 2,712,097 | 1.7% |
| Masimo Corp(MASI) | COM | 574795100 | $114.9M | 683,294 | 1.6% |
| Establishment Labs Hldgs Inc(ESTA) | COM | G31249108 | $110.4M | 2,584,131 | 1.6% |
| Intuitive Surgical Inc(ISRG) | COM NEW | 46120E602 | $110.0M | 202,456 | 1.6% |
| Cytokinetics Inc(CYTK) | COM NEW | 23282W605 | $89.9M | 2,721,158 | 1.3% |
| Quest Diagnostics Inc(DGX) | COM | 74834L100 | $89.8M | 500,000 | 1.3% |
| Uniqure NV(QURE) | SHS | N90064101 | $71.9M | 5,158,231 | 1.0% |
| GH Research PLC(GHRS) | ORDINARY SHARES | G3855L106 | $67.5M | 5,540,457 | 1.0% |
| Urogen Pharma LTD(URGN) | COM | M96088105 | $62.3M | 4,543,895 | 0.9% |
| Ultragenyx Pharmaceutical in(RARE) | COM | 90400D108 | $62.1M | 1,707,402 | 0.9% |
| Abbott Labs(ABT) | COM | 002824100 | $60.4M | 444,000 | 0.9% |
| Stoke Therapeutics Inc(STOK) | COM | 86150R107 | $58.2M | 5,123,525 | 0.8% |
| Taysha Gene Therapies Inc(TSHA) | COM SHS | 877619106 | $57.8M | 25,021,584 | 0.8% |
| Spyre Therapeutics Inc(SYRE) | COM NEW | 00773J202 | $54.2M | 3,621,996 | 0.8% |
| Beta Bionics Inc(BBNX) | COM | 08659B102 | $48.0M | 3,299,191 | 0.7% |
| GE Healthcare Technologies I(GEHC) | COMMON STOCK | 36266G107 | $46.4M | 626,000 | 0.7% |
| Guardant Health Inc(GH) | COM | 40131M109 | $44.6M | 856,501 | 0.6% |
| CG Oncology Inc(CGON) | COM | 156944100 | $44.2M | 1,701,216 | 0.6% |
| Rocket Pharmaceuticals Inc(RCKT) | COM | 77313F106 | $43.3M | 17,687,772 | 0.6% |
| Immatics N.v(IMTX) | SHS | N44445109 | $37.5M | 6,970,152 | 0.5% |
| Soleno Therapeutics Inc(SLNO) | COM | 834203309 | $35.6M | 424,408 | 0.5% |
| Moonlake Immunotherapeutics(MLTX) | CLASS A ORD | 61559X104 | $35.0M | 741,090 | 0.5% |
| Tempus AI Inc(TEM) | CL A | 88023B103 | $25.4M | 400,000 | 0.4% |
| Lenz Therapeutics Inc(LENZ) | COM | 52635N103 | $25.3M | 863,389 | 0.4% |
| Compass Pathways PLC(CMPS) | SPONSORED ADS | 20451W101 | $23.0M | 8,221,929 | 0.3% |
| Orchestra Biomed Hldgs Inc(OBIO) | COM | 68572M106 | $22.3M | 8,306,062 | 0.3% |
| Oruka Therapeutics Inc(ORKA) | COM | 687604108 | $21.8M | 1,945,649 | 0.3% |
| Neurogene Inc(NGNE) | COM | 64135M105 | $20.4M | 1,362,456 | 0.3% |
| Centessa Pharmaceuticals PLC(CNTA) | SPONSORED ADS | 152309100 | $20.1M | 1,529,836 | 0.3% |
| 89Bio Inc(ETNBGBP) | COM | 282559103 | $19.3M | 1,967,527 | 0.3% |