Q3 2025 Holdings
Filed 2025-11-14 | 74 holdings | $8.1B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Madrigal Pharmaceuticals Inc(MDGL) | COM | 558868105 | $914.4M | 1,993,687 | 11.3% |
| Argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $496.7M | 673,497 | 6.1% |
| Avidity Biosciences Inc(RNA) | COM | 05370A108 | $495.5M | 11,372,829 | 6.1% |
| PTC Therapeutics Inc(PTCT) | COM | 69366J200 | $475.4M | 7,746,415 | 5.9% |
| Insmed Inc(INSM) | COM PAR $.01 | 457669307 | $444.2M | 3,084,558 | 5.5% |
| Protagonist Therapeutics Inc(PTGX) | COM | 74366E102 | $382.4M | 5,756,277 | 4.7% |
| Natera Inc(NTRA) | COM | 632307104 | $321.9M | 2,000,000 | 4.0% |
| Akero Therapeutics Inc(AKRO) | COM | 00973Y108 | $260.1M | 5,477,561 | 3.2% |
| Uniqure NV(QURE) | SHS | N90064101 | $258.3M | 4,424,968 | 3.2% |
| Penumbra Inc(PEN) | COM | 70975L107 | $219.5M | 866,499 | 2.7% |
| Radnet Inc(RDNT) | COM | 750491102 | $214.6M | 2,815,544 | 2.6% |
| Merus N V | COM | N5749R100 | $190.7M | 2,025,277 | 2.3% |
| Tarsus Pharmaceuticals Inc(TARS) | COM | 87650L103 | $188.8M | 3,177,436 | 2.3% |
| Stryker Corporation(SYK) | COM | 863667101 | $181.1M | 490,000 | 2.2% |
| Immunocore Hldgs PLC(IMCR) | ADS | 45258D105 | $176.9M | 4,869,798 | 2.2% |
| Acadia Pharmaceuticals Inc(ACAD) | COM | 004225108 | $152.5M | 7,144,524 | 1.9% |
| Cytokinetics Inc(CYTK) | COM NEW | 23282W605 | $149.6M | 2,721,158 | 1.8% |
| Neurocrine Biosciences Inc(NBIX) | COM | 64125C109 | $149.1M | 1,062,072 | 1.8% |
| Axsome Therapeutics Inc(AXSM) | COM | 05464T104 | $135.9M | 1,118,883 | 1.7% |
| Stoke Therapeutics Inc(STOK) | COM | 86150R107 | $120.4M | 5,123,525 | 1.5% |
| Apogee Therapeutics Inc(APGE) | COM | 03770N101 | $107.8M | 2,712,097 | 1.3% |
| Establishment Labs Hldgs Inc(ESTA) | COM | G31249108 | $106.1M | 2,588,831 | 1.3% |
| Masimo Corp(MASI) | COM | 574795100 | $100.8M | 683,294 | 1.2% |
| Ultragenyx Pharmaceutical in(RARE) | COM | 90400D108 | $98.0M | 3,258,266 | 1.2% |
| Guardant Health Inc(GH) | COM | 40131M109 | $92.5M | 1,481,033 | 1.1% |
| Urogen Pharma LTD(URGN) | COM | M96088105 | $90.7M | 4,543,895 | 1.1% |
| Intuitive Surgical Inc(ISRG) | COM NEW | 46120E602 | $90.5M | 202,456 | 1.1% |
| GH Research PLC(GHRS) | ORDINARY SHARES | G3855L106 | $79.6M | 5,569,564 | 1.0% |
| Taysha Gene Therapies Inc(TSHA) | COM SHS | 877619106 | $79.6M | 24,354,291 | 1.0% |
| ZAI LAB LTD(ZLAB) | ADR | 98887Q104 | $77.7M | 2,291,372 | 1.0% |
| Immatics N.v(IMTX) | SHS | N44445109 | $75.1M | 8,815,617 | 0.9% |
| Xencor Inc(XNCR) | COM | 98401F105 | $73.0M | 6,221,054 | 0.9% |
| CG Oncology Inc(CGON) | COM | 156944100 | $68.5M | 1,701,216 | 0.8% |
| Beta Bionics Inc(BBNX) | COM | 08659B102 | $65.6M | 3,299,191 | 0.8% |
| Spyre Therapeutics Inc(SYRE) | COM NEW | 00773J202 | $60.7M | 3,621,996 | 0.7% |
| Rocket Pharmaceuticals Inc(RCKT) | COM | 77313F106 | $57.7M | 17,687,772 | 0.7% |
| Centessa Pharmaceuticals PLC(CNTA) | SPONSORED ADS | 152309100 | $55.6M | 2,291,747 | 0.7% |
| Alkermes PLC(ALKS) | SHS | G01767105 | $50.2M | 1,672,356 | 0.6% |
| Compass Pathways PLC(CMPS) | SPONSORED ADS | 20451W101 | $49.9M | 8,707,390 | 0.6% |
| Cogent Biosciences Inc(COGT) | COM | 19240Q201 | $49.8M | 3,467,486 | 0.6% |
| Verastem Inc(VSTM) | COM NEW | 92337C203 | $47.9M | 5,426,306 | 0.6% |
| Quest Diagnostics Inc(DGX) | COM | 74834L100 | $47.6M | 250,000 | 0.6% |
| Lenz Therapeutics Inc(LENZ) | COM | 52635N103 | $40.2M | 863,389 | 0.5% |
| Rapt Therapeutics Inc(RAPT) | COM NEW | 75382E208 | $37.9M | 1,470,499 | 0.5% |
| Oruka Therapeutics Inc(ORKA) | COM | 687604108 | $37.4M | 1,945,649 | 0.5% |
| Dyne Therapeutics Inc(DYN) | COM | 26818M108 | $36.6M | 2,890,567 | 0.5% |
| Crinetics Pharmaceuticals in(CRNX) | COM | 22663K107 | $36.3M | 872,387 | 0.4% |
| Aquestive Therapeutics Inc(AQST) | COM | 03843E104 | $34.9M | 6,250,000 | 0.4% |
| Abivax SA(ABVX) | SPONSORED ADS | 00370M103 | $29.7M | 350,000 | 0.4% |
| GE Healthcare Technologies I(GEHC) | COMMON STOCK | 36266G107 | $29.6M | 393,500 | 0.4% |