Q4 2025 Holdings
Filed 2026-02-17 | 91 holdings | $10.0B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Madrigal Pharmaceuticals Inc(MDGL) | COM | 558868105 | $1.2B | 1,993,687 | 11.6% |
| Insmed Inc(INSM) | COM PAR $.01 | 457669307 | $842.9M | 4,842,879 | 8.4% |
| PTC Therapeutics Inc(PTCT) | COM | 69366J200 | $588.4M | 7,746,415 | 5.9% |
| Argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $566.4M | 673,497 | 5.7% |
| Protagonist Therapeutics Inc(PTGX) | COM | 74366E102 | $441.9M | 5,059,053 | 4.4% |
| Natera Inc(NTRA) | COM | 632307104 | $343.6M | 1,500,000 | 3.4% |
| Radnet Inc(RDNT) | COM | 750491102 | $281.0M | 3,938,500 | 2.8% |
| Tarsus Pharmaceuticals Inc(TARS) | COM | 87650L103 | $273.1M | 3,335,320 | 2.7% |
| Cogent Biosciences Inc(COGT) | COM | 19240Q201 | $269.7M | 7,592,241 | 2.7% |
| Penumbra Inc(PEN) | COM | 70975L107 | $269.4M | 866,499 | 2.7% |
| Irhythm Technologies Inc(IRTC) | COM | 450056106 | $209.7M | 1,181,990 | 2.1% |
| Apogee Therapeutics Inc(APGE) | COM | 03770N101 | $204.7M | 2,712,097 | 2.1% |
| Apellis Pharmaceuticals Inc(APLS) | COM | 03753U106 | $192.6M | 7,666,764 | 1.9% |
| Acadia Pharmaceuticals Inc(ACAD) | COM | 004225108 | $190.8M | 7,144,524 | 1.9% |
| Establishment Labs Hldgs Inc(ESTA) | COM | G31249108 | $188.7M | 2,588,831 | 1.9% |
| Stoke Therapeutics Inc(STOK) | COM | 86150R107 | $176.1M | 5,546,856 | 1.8% |
| Repligen Corp(RGEN) | COM | 759916109 | $174.3M | 1,064,000 | 1.7% |
| Cytokinetics Inc(CYTK) | COM NEW | 23282W605 | $172.9M | 2,721,158 | 1.7% |
| Immunocore Hldgs PLC(IMCR) | ADS | 45258D105 | $169.0M | 4,869,798 | 1.7% |
| Axsome Therapeutics Inc(AXSM) | COM | 05464T104 | $162.2M | 888,001 | 1.6% |
| Guardant Health Inc(GH) | COM | 40131M109 | $151.3M | 1,481,033 | 1.5% |
| Neurocrine Biosciences Inc(NBIX) | COM | 64125C109 | $150.6M | 1,062,072 | 1.5% |
| Spyre Therapeutics Inc(SYRE) | COM NEW | 00773J202 | $136.7M | 4,171,996 | 1.4% |
| ZAI LAB LTD(ZLAB) | ADR | 98887Q104 | $122.8M | 6,959,032 | 1.2% |
| Immatics N.v(IMTX) | SHS | N44445109 | $120.1M | 11,433,354 | 1.2% |
| Belite BIO Inc(BLTE) | SPONSORED ADS | 07782B104 | $114.4M | 715,332 | 1.1% |
| Urogen Pharma LTD(URGN) | COM | M96088105 | $106.4M | 4,543,895 | 1.1% |
| Xencor Inc(XNCR) | COM | 98401F105 | $103.8M | 6,777,461 | 1.0% |
| Insulet Corp(PODD) | COM | 45784P101 | $92.3M | 324,600 | 0.9% |
| Taysha Gene Therapies Inc(TSHA) | COM SHS | 877619106 | $90.2M | 16,398,297 | 0.9% |
| Masimo Corp(MASI) | COM | 574795100 | $88.9M | 683,294 | 0.9% |
| Uniqure NV(QURE) | SHS | N90064101 | $88.8M | 3,711,462 | 0.9% |
| Stryker Corporation(SYK) | COM | 863667101 | $86.1M | 245,000 | 0.9% |
| CG Oncology Inc(CGON) | COM | 156944100 | $83.5M | 2,012,127 | 0.8% |
| Castle Biosciences Inc(CSTL) | COM | 14843C105 | $82.3M | 2,115,237 | 0.8% |
| Immunovant Inc(IMVT) | COM | 45258J102 | $80.8M | 3,177,850 | 0.8% |
| Beta Bionics Inc(BBNX) | COM | 08659B102 | $76.2M | 2,500,000 | 0.8% |
| GH Research PLC(GHRS) | ORDINARY SHARES | G3855L106 | $75.4M | 5,933,815 | 0.8% |
| Replimune Group Inc(REPL) | COM | 76029N106 | $69.4M | 7,140,352 | 0.7% |
| Ultragenyx Pharmaceutical in(RARE) | COM | 90400D108 | $69.0M | 3,000,139 | 0.7% |
| Crinetics Pharmaceuticals in(CRNX) | COM | 22663K107 | $62.9M | 1,351,326 | 0.6% |
| Oruka Therapeutics Inc(ORKA) | COM | 687604108 | $62.4M | 2,058,148 | 0.6% |
| Rocket Pharmaceuticals Inc(RCKT) | COM | 77313F106 | $62.1M | 17,687,772 | 0.6% |
| Compass Pathways PLC(CMPS) | SPONSORED ADS | 20451W101 | $60.4M | 8,757,390 | 0.6% |
| Intuitive Surgical Inc(ISRG) | COM NEW | 46120E602 | $57.3M | 101,228 | 0.6% |
| Rapt Therapeutics Inc(RAPT) | COM NEW | 75382E208 | $55.5M | 1,637,165 | 0.6% |
| Celcuity Inc(CELC) | COM | 15102K100 | $54.9M | 550,160 | 0.5% |
| Verastem Inc(VSTM) | COM NEW | 92337C203 | $50.8M | 6,576,306 | 0.5% |
| Alkermes PLC(ALKS) | SHS | G01767105 | $46.8M | 1,672,356 | 0.5% |
| Centessa Pharmaceuticals PLC(CNTA) | SPONSORED ADS | 152309100 | $44.8M | 1,790,837 | 0.4% |