Q4 2022 Holdings
Filed 2023-02-14 | 85 holdings | $4.6B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Spdr SER TR(XBI)Call | S&P BIOTECH | 78464A870 | $337.1M | 4,062,000 | 7.3% |
| Argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $236.8M | 625,000 | 5.1% |
| United Therapeutics Corp del(UTHR) | COM | 91307C102 | $218.4M | 785,500 | 4.7% |
| Neurocrine Biosciences Inc(NBIX) | COM | 64125C109 | $212.6M | 1,780,000 | 4.6% |
| Akero Therapeutics Inc(AKRO) | COM | 00973Y108 | $209.6M | 3,825,000 | 4.5% |
| Prothena Corp PLC(PRTA) | SHS | G72800108 | $177.9M | 2,953,000 | 3.9% |
| Arvinas Inc(ARVN) | COM | 04335A105 | $169.3M | 4,950,000 | 3.7% |
| Boston Scientific Corp(BSX) | COM | 101137107 | $150.7M | 3,256,700 | 3.3% |
| Syndax Pharmaceuticals Inc(SNDX) | COM | 87164F105 | $149.2M | 5,861,000 | 3.2% |
| Ultragenyx Pharmaceutical in(RARE) | COM | 90400D108 | $138.5M | 2,990,000 | 3.0% |
| Sarepta Therapeutics Inc(SRPT) | COM | 803607100 | $136.7M | 1,055,000 | 3.0% |
| Madrigal Pharmaceuticals Inc(MDGL) | COM | 558868105 | $124.8M | 430,000 | 2.7% |
| Universal Hlth Svcs Inc(UHS) | CL B | 913903100 | $116.3M | 825,600 | 2.5% |
| Jazz Pharmaceuticals PLC(JAZZ) | SHS USD | G50871105 | $115.9M | 727,541 | 2.5% |
| Zentalis Pharmaceuticals Inc(ZNTL) | COM | 98943L107 | $103.7M | 5,150,000 | 2.2% |
| Acadia Healthcare Company in(ACHC) | COM | 00404A109 | $95.9M | 1,165,000 | 2.1% |
| Surgery Partners Inc(SGRY) | COM | 86881A100 | $86.7M | 3,112,000 | 1.9% |
| Dexcom Inc(DXCM) | COM | 252131107 | $85.7M | 756,800 | 1.9% |
| Astrazeneca PLC(AZN) | SPONSORED ADR | 046353108 | $81.4M | 1,200,000 | 1.8% |
| Lilly ELI & Co(LLY) | COM | 532457108 | $79.4M | 217,000 | 1.7% |
| Vaxcyte Inc(PCVX) | COM | 92243G108 | $77.5M | 1,615,400 | 1.7% |
| Avidity Biosciences Inc(RNA) | COM | 05370A108 | $72.7M | 3,275,000 | 1.6% |
| Natera Inc(NTRA) | COM | 632307104 | $72.3M | 1,798,900 | 1.6% |
| Ideaya Biosciences Inc(IDYA) | COM | 45166A102 | $69.5M | 3,824,800 | 1.5% |
| Immunocore Hldgs PLC(IMCR) | ADS | 45258D105 | $65.9M | 1,154,000 | 1.4% |
| Altimmune Inc(ALT) | COM NEW | 02155H200 | $65.6M | 3,990,000 | 1.4% |
| Revolution Medicines Inc(RVMD) | COM | 76155X100 | $59.0M | 2,475,000 | 1.3% |
| Karuna Therapeutics Inc | COM | 48576A100 | $58.8M | 299,000 | 1.3% |
| Arrowhead Pharmaceuticals in(ARWR) | COM | 04280A100 | $55.8M | 1,375,000 | 1.2% |
| Axsome Therapeutics Inc(AXSM) | COM | 05464T104 | $51.7M | 670,000 | 1.1% |
| Vertex Pharmaceuticals Inc(VRTX) | COM | 92532F100 | $49.7M | 172,000 | 1.1% |
| Legend Biotech Corp(LEGN) | SPONSORED ADS | 52490G102 | $48.4M | 970,000 | 1.0% |
| Kezar Life Sciences Inc | COM | 49372L100 | $47.7M | 6,782,400 | 1.0% |
| Pliant Therapeutics Inc(PLRX) | COM | 729139105 | $43.3M | 2,240,400 | 0.9% |
| Ventyx Biosciences Inc(VTYX) | COM | 92332V107 | $42.1M | 1,285,000 | 0.9% |
| Icon PLC(ICLR) | SHS | G4705A100 | $41.8M | 215,000 | 0.9% |
| Quest Diagnostics Inc(DGX) | COM | 74834L100 | $40.4M | 258,000 | 0.9% |
| BIO RAD Labs Inc(BIO) | CL A | 090572207 | $38.8M | 92,200 | 0.8% |
| Bellus Health Inc New(BLU) | COM NEW | 07987C204 | $37.8M | 4,599,998 | 0.8% |
| Tenet Healthcare Corp(THC) | COM NEW | 88033G407 | $35.0M | 717,300 | 0.8% |
| Karyopharm Therapeutics Inc(KPTIEUR) | COM | 48576U106 | $32.8M | 9,633,911 | 0.7% |
| Biontech SE(BNTX) | SPONSORED ADS | 09075V102 | $32.4M | 215,400 | 0.7% |
| Verve Therapeutics Inc | COM | 92539P101 | $30.3M | 1,565,000 | 0.7% |
| Rocket Pharmaceuticals Inc(RCKT) | COM | 77313F106 | $29.9M | 1,527,087 | 0.6% |
| Intra-Cellular Therapies Inc(ITCIEUR) | COM | 46116X101 | $26.7M | 504,000 | 0.6% |
| Arcutis Biotherapeutics Inc(ARQT) | COM | 03969K108 | $26.0M | 1,755,000 | 0.6% |
| Prometheus Biosciences Inc | COM | 74349U108 | $22.4M | 204,000 | 0.5% |
| Intellia Therapeutics Inc(NTLA) | COM | 45826J105 | $22.3M | 638,200 | 0.5% |
| VIR Biotechnology Inc(VIR) | COM | 92764N102 | $21.5M | 850,000 | 0.5% |
| Phathom Pharmaceuticals Inc(PHAT) | COM | 71722W107 | $21.3M | 1,900,000 | 0.5% |