Q4 2025 Holdings
Filed 2026-02-12 | 95 holdings | $2.7B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Spdr Series Trust(XBI)Put | STATE STREET SPD | 78464A870 | $353.6M | 2,900,000 | 13.0% |
| Krystal Biotech Inc(KRYS) | COM | 501147102 | $232.0M | 941,059 | 8.6% |
| Celcuity Inc(CELC) | COM | 15102K100 | $180.4M | 1,808,258 | 6.7% |
| Novocure LTD(NVCR) | ORD SHS | G6674U108 | $110.3M | 8,530,665 | 4.1% |
| Praxis Precision Medicines I(PRAX) | COM NEW | 74006W207 | $107.0M | 362,966 | 3.9% |
| TG Therapeutics Inc(TGTX) | COM | 88322Q108 | $93.6M | 3,139,312 | 3.5% |
| Dexcom Inc(DXCM) | COM | 252131107 | $86.1M | 1,297,094 | 3.2% |
| Biomarin Pharmaceutical Inc(BMRN) | COM | 09061G101 | $78.4M | 1,320,000 | 2.9% |
| Globus MED Inc(GMED) | CL A | 379577208 | $77.4M | 887,000 | 2.9% |
| Beta Bionics Inc(BBNX) | COM | 08659B102 | $77.2M | 2,534,565 | 2.8% |
| Amicus Therapeutics Inc(FOLD) | COM | 03152W109 | $74.2M | 5,207,284 | 2.7% |
| Twist Bioscience Corp(TWST) | COM | 90184D100 | $59.1M | 1,861,802 | 2.2% |
| Organogenesis Hldgs Inc(ORGO) | COM | 68621F102 | $51.7M | 9,985,951 | 1.9% |
| Syndax Pharmaceuticals Inc(SNDX) | COM | 87164F105 | $47.2M | 2,247,110 | 1.7% |
| Mirum Pharmaceuticals Inc(MIRM) | COM | 604749101 | $45.3M | 573,614 | 1.7% |
| Insulet Corp(PODD) | COM | 45784P101 | $42.6M | 150,000 | 1.6% |
| Neuropace Inc(NPCE) | COM | 641288105 | $41.7M | 2,703,208 | 1.5% |
| Axogen Inc(AXGN) | COM | 05463X106 | $39.5M | 1,206,855 | 1.5% |
| ANI Pharmaceuticals Inc(ANIP) | COM | 00182C103 | $38.4M | 486,243 | 1.4% |
| Alkermes PLC(ALKS) | SHS | G01767105 | $37.0M | 1,322,364 | 1.4% |
| Livanova PLC(LIVN) | SHS | G5509L101 | $34.9M | 567,500 | 1.3% |
| GSK PLC(GSK) | SPONSORED ADR | 37733W204 | $31.3M | 639,000 | 1.2% |
| Geron Corp(GERN) | COM | 374163103 | $30.7M | 23,290,000 | 1.1% |
| United Therapeutics Corp del(UTHR) | COM | 91307C102 | $29.2M | 60,000 | 1.1% |
| Immunovant Inc(IMVT) | COM | 45258J102 | $28.2M | 1,110,000 | 1.0% |
| Vaxcyte Inc(PCVX) | COM | 92243G108 | $28.1M | 608,958 | 1.0% |
| Alnylam Pharmaceuticals Inc(ALNY) | COM | 02043Q107 | $27.8M | 70,000 | 1.0% |
| Inspire MED SYS Inc(INSP) | COM | 457730109 | $27.6M | 299,399 | 1.0% |
| Vericel Corp(VCEL) | COM | 92346J108 | $27.5M | 764,000 | 1.0% |
| Argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $26.7M | 31,726 | 1.0% |
| Rapt Therapeutics Inc(RAPT) | COM NEW | 75382E208 | $25.9M | 764,000 | 1.0% |
| Neurocrine Biosciences Inc(NBIX) | COM | 64125C109 | $25.0M | 175,982 | 0.9% |
| Kiniksa Pharmaceuticals Intl(KNSA) | ORD SHS CL A | G52694109 | $24.2M | 587,000 | 0.9% |
| Edap TMS S A(EDA) | SPONSORED ADR | 268311107 | $24.0M | 7,309,254 | 0.9% |
| Teleflex Incorporated(TFX) | COM | 879369106 | $23.2M | 190,000 | 0.9% |
| Nurix Therapeutics Inc(NRIX) | COM | 67080M103 | $23.1M | 1,219,394 | 0.9% |
| Edgewise Therapeutics Inc(EWTX) | COM | 28036F105 | $22.6M | 910,000 | 0.8% |
| Inhibikase Therapeutics Inc(IKT) | COM NEW | 45719W205 | $22.3M | 10,875,000 | 0.8% |
| Pharvaris N V(PHVS) | COM | N69605108 | $19.5M | 702,052 | 0.7% |
| Invivyd Inc(IVVD) | COM | 00534A102 | $19.0M | 7,708,727 | 0.7% |
| Capricor Therapeutics Inc(CAPR) | COM NEW | 14070B309 | $18.7M | 646,390 | 0.7% |
| Tenet Healthcare Corp(THC) | COM NEW | 88033G407 | $18.4M | 92,500 | 0.7% |
| Arcus Biosciences Inc(RCUS) | COM | 03969F109 | $17.0M | 711,983 | 0.6% |
| Enliven Therapeutics Inc(ELVN) | COM | 29337E102 | $15.8M | 1,025,000 | 0.6% |
| MBX Biosciences Inc(MBX) | COM | 55287L101 | $12.9M | 408,900 | 0.5% |
| Rigel Pharmaceuticals Inc(RIGL) | COM | 766559702 | $12.9M | 300,034 | 0.5% |
| Jade Biosciences Inc(JBIO) | COM NEW | 008064206 | $12.3M | 796,744 | 0.5% |
| Trevi Therapeutics Inc(TRVI) | COM | 89532M101 | $11.3M | 900,000 | 0.4% |
| Sionna Therapeutics Inc(SION) | COM | 829401108 | $11.0M | 268,500 | 0.4% |
| Septerna Inc(SEPN) | COM | 81734D104 | $10.7M | 383,368 | 0.4% |