Q3 2025 Holdings
Filed 2025-11-14 | 47 holdings | $3.3B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Mirum Pharmaceuticals Inc(MIRM) | COM | 604749101 | $498.2M | 6,795,121 | 14.9% |
| Newamsterdam Pharma Company(NAMS) | ORDINARY SHARES | N62509109 | $475.0M | 16,701,956 | 14.2% |
| Verona Pharma PLC(VRNA) | SPONSORED ADS | 925050106 | $361.1M | 3,383,950 | 10.8% |
| Bridgebio Pharma Inc(BBIO) | COM | 10806X102 | $199.7M | 3,845,457 | 6.0% |
| Arcutis Biotherapeutics Inc(ARQT) | COM | 03969K108 | $186.1M | 9,874,511 | 5.6% |
| Phathom Pharmaceuticals Inc(PHAT) | COM | 71722W107 | $146.7M | 12,466,489 | 4.4% |
| Krystal Biotech Inc(KRYS) | COM | 501147102 | $121.5M | 688,460 | 3.6% |
| Maze Therapeutics Inc(MAZE) | COM | 578784100 | $118.4M | 4,567,274 | 3.5% |
| MBX Biosciences Inc(MBX) | COM | 55287L101 | $116.4M | 6,652,013 | 3.5% |
| Disc Medicine Inc(IRON) | COM | 254604101 | $95.1M | 1,438,534 | 2.8% |
| Trevi Therapeutics Inc(TRVI) | COM | 89532M101 | $93.9M | 10,259,409 | 2.8% |
| Tarsus Pharmaceuticals Inc(TARS) | COM | 87650L103 | $69.4M | 1,167,527 | 2.1% |
| Kalvista Pharmaceuticals Inc(KALV) | COM | 483497103 | $61.4M | 5,039,867 | 1.8% |
| ZAI LAB LTD(ZLAB) | ADR | 98887Q104 | $55.1M | 1,627,320 | 1.7% |
| Agios Pharmaceuticals Inc(AGIO) | COM | 00847X104 | $51.4M | 1,279,754 | 1.5% |
| Erasca Inc(ERAS) | COM | 29479A108 | $49.6M | 22,729,436 | 1.5% |
| Cytokinetics Inc(CYTK) | COM NEW | 23282W605 | $48.9M | 890,445 | 1.5% |
| Revolution Medicines Inc(RVMD) | COM | 76155X100 | $46.6M | 997,455 | 1.4% |
| Palvella Therapeutics Inc NE(PVLA) | COM | 697947109 | $45.3M | 722,400 | 1.4% |
| Savara Inc(SVRA) | COM | 805111101 | $40.9M | 11,462,301 | 1.2% |
| Dyne Therapeutics Inc(DYN) | COM | 26818M108 | $34.4M | 2,718,105 | 1.0% |
| Abivax SA(ABVX) | SPONSORED ADS | 00370M103 | $32.1M | 378,300 | 1.0% |
| Aura Biosciences Inc(AURA) | COM | 05153U107 | $31.5M | 5,100,000 | 0.9% |
| Ultragenyx Pharmaceutical in(RARE) | COM | 90400D108 | $29.6M | 983,715 | 0.9% |
| Lexeo Therapeutics Inc(LXEO) | COM | 52886X107 | $29.4M | 4,424,725 | 0.9% |
| Valneva SE(VALN) | SPONSORED ADS | 92025Y103 | $28.0M | 2,291,666 | 0.8% |
| Avidity Biosciences Inc(RNA) | COM | 05370A108 | $27.2M | 625,000 | 0.8% |
| Ascendis Pharma A/S(ASND) | SPONSORED ADR | 04351P101 | $26.5M | 133,333 | 0.8% |
| Alkermes PLC(ALKS) | SHS | G01767105 | $21.0M | 700,647 | 0.6% |
| Mereo Biopharma Group PLC(MREO) | SPON ADS | 589492107 | $19.4M | 9,440,112 | 0.6% |
| Akero Therapeutics Inc(AKRO) | COM | 00973Y108 | $17.4M | 366,784 | 0.5% |
| Vaxcyte Inc(PCVX) | COM | 92243G108 | $17.1M | 474,405 | 0.5% |
| Evolus Inc(EOLS) | COM | 30052C107 | $16.2M | 2,630,665 | 0.5% |
| Design Therapeutics Inc(DSGN) | COM | 25056L103 | $14.7M | 1,953,547 | 0.4% |
| Immunocore Hldgs PLC(IMCR) | ADS | 45258D105 | $14.0M | 384,782 | 0.4% |
| Acadia Pharmaceuticals Inc(ACAD) | COM | 004225108 | $13.1M | 613,837 | 0.4% |
| Jade Biosciences Inc(JBIO) | COM NEW | 008064206 | $12.2M | 1,413,280 | 0.4% |
| Assembly Biosciences Inc(ASMB) | COM NEW | 045396207 | $11.7M | 456,249 | 0.3% |
| Adverum Biotechnologies Inc(AVU0) | COM NEW | 00773U207 | $9.4M | 2,077,431 | 0.3% |
| Travere Therapeutics Inc(TVTX) | COM | 89422G107 | $9.4M | 392,092 | 0.3% |
| Newamsterdam Pharma Company | *W EXP 99/99/999 | N62509117 | $8.6M | 500,333 | 0.3% |
| Engene Holdings Inc(ENGN) | COM | 29286M105 | $7.9M | 1,157,380 | 0.2% |
| Autolus Therapeutics PLC(AUTL) | SPON ADS | 05280R100 | $7.5M | 4,623,324 | 0.2% |
| Macrogenics Inc(MGNX) | COM | 556099109 | $5.3M | 3,175,665 | 0.2% |
| Silence Therapeutics PLC(SLN) | ADS | 82686Q101 | $5.0M | 970,130 | 0.2% |
| Allogene Therapeutics Inc(ALLO) | COM | 019770106 | $4.8M | 3,868,750 | 0.1% |
| Crescent Biopharma Inc.(CBIO) | COM | G2545C104 | $3.2M | 272,951 | 0.1% |