Q4 2022 Holdings
Filed 2023-02-14 | 66 holdings | $3.3B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Prothena Corp PLC(PRTA) | SHS | G72800108 | $698.0M | 11,584,280 | 21.2% |
| Sarepta Therapeutics Inc(SRPT) | COM | 803607100 | $388.7M | 2,999,453 | 11.8% |
| Apellis Pharmaceuticals Inc(APLS) | COM | 03753U106 | $268.0M | 5,183,431 | 8.2% |
| Anaptysbio Inc(ANAB) | COM | 032724106 | $233.1M | 7,521,024 | 7.1% |
| Galapagos NV(GLPG) | SPON ADR | 36315X101 | $165.6M | 3,730,730 | 5.0% |
| Xencor Inc(XNCR) | COM | 98401F105 | $137.6M | 5,282,516 | 4.2% |
| Arvinas Inc(ARVN) | COM | 04335A105 | $106.8M | 3,123,300 | 3.3% |
| Revolution Medicines Inc(RVMD) | COM | 76155X100 | $106.2M | 4,458,731 | 3.2% |
| Morphic Hldg Inc | COM | 61775R105 | $105.7M | 3,951,566 | 3.2% |
| Acadia Pharmaceuticals Inc(ACAD) | COM | 004225108 | $95.4M | 5,991,479 | 2.9% |
| Springworks Therapeutics Inc | COM | 85205L107 | $90.0M | 3,460,208 | 2.7% |
| Kura Oncology Inc(KURA) | COM | 50127T109 | $82.4M | 6,638,371 | 2.5% |
| ZAI LAB LTD(ZLAB) | ADR | 98887Q104 | $66.2M | 2,157,686 | 2.0% |
| Relay Therapeutics Inc(RLAY) | COM | 75943R102 | $62.2M | 4,163,824 | 1.9% |
| Zymeworks del Inc(ZYME) | COM ADDED | 98985Y108 | $59.5M | 7,568,573 | 1.8% |
| Alector Inc(ALEC) | COM | 014442107 | $37.4M | 4,056,548 | 1.1% |
| NGM Biopharmaceuticals Inc(NGMUSD) | COM | 62921N105 | $32.3M | 6,435,518 | 1.0% |
| Adicet BIO Inc(TORCEUR) | COM | 007002108 | $31.8M | 3,560,700 | 1.0% |
| Edgewise Therapeutics Inc(EWTX) | COM | 28036F105 | $31.2M | 3,493,194 | 1.0% |
| Tango Therapeutics Inc(TNGX) | COM | 87583X109 | $30.5M | 4,201,414 | 0.9% |
| Atea Pharmaceuticals Inc(AVIR) | COM | 04683R106 | $29.7M | 6,184,861 | 0.9% |
| Voyager Therapeutics Inc(VYGR) | COM | 92915B106 | $29.0M | 4,753,907 | 0.9% |
| Allogene Therapeutics Inc(ALLO) | COM | 019770106 | $28.2M | 4,488,200 | 0.9% |
| Dyne Therapeutics Inc(DYN) | COM | 26818M108 | $26.9M | 2,322,384 | 0.8% |
| Nuvation BIO Inc(NUVB) | COM CL A | 67080N101 | $26.7M | 13,896,543 | 0.8% |
| Crinetics Pharmaceuticals in(CRNX) | COM | 22663K107 | $24.3M | 1,330,263 | 0.7% |
| Oric Pharmaceuticals Inc(ORIC) | COM | 68622P109 | $20.1M | 3,418,068 | 0.6% |
| Kymera Therapeutics Inc(KYMR) | COM | 501575104 | $19.9M | 796,093 | 0.6% |
| Graphite BIO Inc(GRPH) | COM | 38870X104 | $19.0M | 5,712,096 | 0.6% |
| Janux Therapeutics Inc(JANX) | COM | 47103J105 | $18.7M | 1,421,319 | 0.6% |
| Chinook Therapeutics Inc(290A) | COM | 16961L106 | $18.1M | 690,000 | 0.6% |
| Centessa Pharmaceuticals PLC(CNTA) | SPONSORED ADS | 152309100 | $16.2M | 5,232,279 | 0.5% |
| Poseida Therapeutics Inc(PSTXUSD) | COM | 73730P108 | $14.0M | 2,650,000 | 0.4% |
| Ventyx Biosciences Inc(VTYX) | COM | 92332V107 | $13.1M | 400,000 | 0.4% |
| Ovid Therapeutics Inc(OVID) | COM | 690469101 | $11.4M | 6,117,400 | 0.3% |
| Prime Medicine Inc(PRME) | COM ADDED | 74168J101 | $11.1M | 600,000 | 0.3% |
| Cullinan Oncology Inc(CGEM) | COM | 230031106 | $10.9M | 1,035,038 | 0.3% |
| 2Seventy BIO Inc(TSVT*) | COMMON STOCK | 901384107 | $10.7M | 1,143,494 | 0.3% |
| Geron Corp(GERN) | COM | 374163103 | $9.7M | 4,028,507 | 0.3% |
| Aveo Pharmaceuticals Inc(0HJQ) | COM NEW | 053588307 | $9.7M | 650,489 | 0.3% |
| Bioatla Inc(BCAB) | COM | 09077B104 | $9.3M | 1,124,439 | 0.3% |
| Design Therapeutics Inc(DSGN) | COM | 25056L103 | $9.1M | 884,903 | 0.3% |
| Gracell Biotechnologies Inc | SPONSORED ADS | 38406L103 | $7.7M | 3,343,202 | 0.2% |
| Macrogenics Inc(MGNX) | COM | 556099109 | $7.5M | 1,117,455 | 0.2% |
| Immatics N.v(IMTX) | SHS | N44445109 | $6.5M | 743,000 | 0.2% |
| Arcutis Biotherapeutics Inc(ARQT) | COM | 03969K108 | $6.1M | 415,322 | 0.2% |
| Precision Biosciences Inc | COM | 74019P108 | $6.0M | 5,035,971 | 0.2% |
| Health Sciences ACQ Corp 2 | ORD SHS | G4411D109 | $4.0M | 400,000 | 0.1% |
| Selecta Biosciences Inc(SELBUSD) | COM | 816212104 | $4.0M | 3,500,000 | 0.1% |
| Praxis Precision Medicines I | COM | 74006W108 | $3.8M | 1,585,324 | 0.1% |