Q4 2025 Holdings
Filed 2026-02-17 | 72 holdings | $9.8B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Ascendis Pharma A/S(ASND) | SH | 04351P101 | $2.2B | 10,281,496 | 22.5% |
| Cidara Therapeutics Inc(CDTX) | SH | 171757206 | $743.4M | 3,365,523 | 7.6% |
| Rhythm Pharmaceuticals Inc(RYTM) | SH | 76243J105 | $713.6M | 6,666,837 | 7.3% |
| Avidity Biosciences Inc(RNA) | SH | 05370A108 | $623.3M | 8,641,031 | 6.4% |
| Vaxcyte Inc(PCVX) | SH | 92243G108 | $494.8M | 10,724,599 | 5.1% |
| Sionna Therapeutics Inc(SION) | SH | 829401108 | $407.5M | 9,905,045 | 4.2% |
| Newamsterdam Pharma Co NV(NAMS) | SH | N62509109 | $335.0M | 9,550,191 | 3.4% |
| Tyra Biosciences Inc(TYRA) | SH | 90240B106 | $320.7M | 12,198,625 | 3.3% |
| Wave Life Sciences LTD(WVE) | SH | Y95308105 | $309.5M | 18,203,009 | 3.2% |
| Mineralys Therapeutics Inc(MLYS) | SH | 603170101 | $265.8M | 7,323,750 | 2.7% |
| Edgewise Therapeutics Inc(EWTX) | SH | 28036F105 | $258.8M | 10,428,437 | 2.7% |
| Septerna Inc(SEPN) | SH | 81734D104 | $195.0M | 6,995,858 | 2.0% |
| Nuvalent Inc(NUVL) | SH | 670703107 | $189.1M | 1,880,057 | 1.9% |
| Disc Medicine Inc(IRON) | SH | 254604101 | $156.9M | 1,976,132 | 1.6% |
| Janux Therapeutics Inc(JANX) | SH | 47103J105 | $154.4M | 11,189,693 | 1.6% |
| Pepgen Inc(PEPG) | SH | 713317105 | $130.6M | 20,064,545 | 1.3% |
| Taysha Gene Therapies Inc(TSHA) | SH | 877619106 | $129.6M | 23,555,648 | 1.3% |
| ARS Pharmaceuticals Inc(SPRY) | SH | 82835W108 | $126.5M | 10,860,977 | 1.3% |
| Biocryst Pharmaceuticals Inc(BCRX) | SH | 09058V103 | $123.5M | 15,827,186 | 1.3% |
| Bicara Therapeutics Inc(BCAX) | SH | 055477103 | $117.1M | 6,955,993 | 1.2% |
| Praxis Precision Medicines I(PRAX) | SH | 74006W207 | $110.2M | 373,787 | 1.1% |
| GH Research PLC(GHRS) | SH | G3855L106 | $97.5M | 7,676,697 | 1.0% |
| Geron Corp(GERN) | SH | 374163103 | $84.2M | 63,771,366 | 0.9% |
| Arcellx Inc(ACLX) | SH | 03940C100 | $82.6M | 1,267,156 | 0.8% |
| Climb BIO Inc(CLYM) | SH | 28658R106 | $77.7M | 11,293,828 | 0.8% |
| VOR Biopharma Inc(VOR) | SH | 929033207 | $70.7M | 5,404,998 | 0.7% |
| Belite BIO Inc(BLTE) | SH | 07782B104 | $69.2M | 432,484 | 0.7% |
| Fulcrum Therapeutics Inc(FULC) | SH | 359616109 | $68.5M | 6,053,960 | 0.7% |
| Lenz Therapeutics Inc(LENZ) | SH | 52635N103 | $66.9M | 4,178,823 | 0.7% |
| Dianthus Therapeutics Inc(DNTH) | SH | 252828108 | $66.4M | 1,611,733 | 0.7% |
| Olema Pharmaceuticals Inc(OLMA) | SH | 68062P106 | $65.0M | 2,600,000 | 0.7% |
| Evommune Inc(EVMN) | SH | 30054Y107 | $59.2M | 3,458,770 | 0.6% |
| Jade Biosciences Inc(JBIO) | SH | 008064206 | $56.6M | 3,671,083 | 0.6% |
| Spyre Therapeutics Inc(SYRE) | SH | 00773J202 | $53.1M | 1,621,620 | 0.5% |
| Lexeo Therapeutics Inc(LXEO) | SH | 52886X107 | $49.7M | 5,000,000 | 0.5% |
| LB Pharmaceuticals Inc(LBRX) | SH | 50180M108 | $49.2M | 2,208,604 | 0.5% |
| Monopar Therapeutics Inc(MNPR) | SH | 61023L207 | $43.6M | 667,207 | 0.4% |
| Capricor Therapeutics Inc(CAPR) | SH | 14070B309 | $43.5M | 1,507,844 | 0.4% |
| 4D Molecular Therapeutics in(FDMT) | SH | 35104E100 | $42.4M | 5,653,211 | 0.4% |
| Invivyd Inc(IVVD) | SH | 00534A102 | $42.3M | 17,119,096 | 0.4% |
| Artiva Biotherapeutics Inc(ARTV) | SH | 04317A107 | $42.3M | 9,853,302 | 0.4% |
| Grail Inc(GRAL) | SH | 384747101 | $36.7M | 428,266 | 0.4% |
| Assembly Biosciences Inc(ASMB) | SH | 045396207 | $34.7M | 1,020,410 | 0.4% |
| Solid Biosciences Inc(SLDB) | SH | 83422E204 | $32.8M | 5,811,423 | 0.3% |
| Acumen Pharmaceuticals Inc(ABOS) | SH | 00509G209 | $31.5M | 14,932,063 | 0.3% |
| Benitec Biopharma Inc(BNTC) | SH | 08205P209 | $24.9M | 1,850,000 | 0.3% |
| Contineum Therapeutics Inc(CTNM) | SH | 21217B100 | $24.9M | 2,179,711 | 0.3% |
| Rezolute Inc(RZLT) | SH | 76200L309 | $21.7M | 9,180,000 | 0.2% |
| Acrivon Therapeutics Inc(ACRV) | SH | 004890109 | $20.1M | 8,340,508 | 0.2% |
| Nkarta Inc(NKTX) | SH | 65487U108 | $20.0M | 10,805,129 | 0.2% |