Q1 2026 Holdings
Filed 2026-05-15 | 86 holdings | $9.4B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Ascendis Pharma A/S(ASND) | SPONSORED ADR | 04351P101 | $2.4B | 10,281,496 | 24.9% |
| Vaxcyte Inc(PCVX) | COMMON STOCK | 92243G108 | $666.8M | 11,474,599 | 7.1% |
| Rhythm Pharmaceuticals Inc(RYTM) | COMMON STOCK | 76243J105 | $579.8M | 6,666,837 | 6.1% |
| Tyra Biosciences Inc(TYRA) | COMMON STOCK | 90240B106 | $467.2M | 12,198,625 | 5.0% |
| Sionna Therapeutics Inc(SION) | COMMON STOCK | 829401108 | $397.1M | 9,905,045 | 4.2% |
| Edgewise Therapeutics Inc(EWTX) | COMMON STOCK | 28036F105 | $328.5M | 10,428,437 | 3.5% |
| Newamsterdam Pharma Co NV(NAMS) | COMMON STOCK | N62509109 | $305.7M | 9,550,191 | 3.2% |
| Nuvalent Inc(NUVL) | COMMON STOCK | 670703107 | $259.6M | 2,534,145 | 2.8% |
| Dianthus Therapeutics Inc(DNTH) | COMMON STOCK | 252828108 | $219.2M | 2,611,733 | 2.3% |
| Mineralys Therapeutics Inc(MLYS) | COMMON STOCK | 603170101 | $208.4M | 7,692,750 | 2.2% |
| Spyglass Pharma Inc(SGP) | COMMON STOCK | 85220G109 | $207.8M | 8,021,117 | 2.2% |
| Wave Life Sciences LTD(WVE) | COMMON STOCK | Y95308105 | $195.6M | 26,975,505 | 2.1% |
| Septerna Inc(SEPN) | COMMON STOCK | 81734D104 | $168.1M | 6,995,858 | 1.8% |
| Disc Medicine Inc(IRON) | COMMON STOCK | 254604101 | $156.7M | 2,450,221 | 1.7% |
| Janux Therapeutics Inc(JANX) | COMMON STOCK | 47103J105 | $155.5M | 11,189,693 | 1.6% |
| Biocryst Pharmaceuticals Inc(BCRX) | COMMON STOCK | 09058V103 | $150.7M | 15,827,186 | 1.6% |
| Bicara Therapeutics Inc(BCAX) | COMMON STOCK | 055477103 | $144.3M | 7,255,993 | 1.5% |
| Praxis Precision Medicines I(PRAX) | COMMON STOCK | 74006W207 | $120.4M | 373,787 | 1.3% |
| GH Research PLC(GHRS) | COMMON STOCK | G3855L106 | $107.9M | 7,676,697 | 1.1% |
| ZAI LAB LTD(ZLAB) | COMMON STOCK | 98887Q104 | $107.4M | 5,707,262 | 1.1% |
| Taysha Gene Therapies Inc(TSHA) | COMMON STOCK | 877619106 | $105.3M | 23,555,648 | 1.1% |
| VOR Biopharma Inc(VOR) | COMMON STOCK | 929033207 | $96.4M | 5,404,998 | 1.0% |
| Geron Corp(GERN) | COMMON STOCK | 374163103 | $95.0M | 63,771,366 | 1.0% |
| ARS Pharmaceuticals Inc(SPRY) | COMMON STOCK | 82835W108 | $87.2M | 10,860,977 | 0.9% |
| Sarepta Therapeutics Inc(SRPT) | COMMON STOCK | 803607100 | $84.9M | 3,902,596 | 0.9% |
| Spyre Therapeutics Inc(SYRE) | COMMON STOCK | 00773J202 | $81.8M | 1,621,620 | 0.9% |
| Evommune Inc(EVMN) | COMMON STOCK | 30054Y107 | $80.3M | 3,494,638 | 0.9% |
| Climb BIO Inc(CLYM) | COMMON STOCK | 28658R106 | $77.4M | 11,300,939 | 0.8% |
| Solid Biosciences Inc(SLDB) | COMMON STOCK | 83422E204 | $67.2M | 9,339,978 | 0.7% |
| Artiva Biotherapeutics Inc(ARTV) | COMMON STOCK | 04317A107 | $63.5M | 9,853,302 | 0.7% |
| Damora Therapeutics Inc(GLTO) | COMMON STOCK | 36322Q206 | $62.1M | 2,399,310 | 0.7% |
| Xencor Inc(XNCR) | COMMON STOCK | 98401F105 | $59.1M | 4,897,237 | 0.6% |
| LB Pharmaceuticals Inc(LBRX) | COMMON STOCK | 50180M108 | $54.5M | 2,208,604 | 0.6% |
| Jade Biosciences Inc(JBIO) | COMMON STOCK | 008064206 | $51.6M | 3,671,083 | 0.5% |
| Acumen Pharmaceuticals Inc(ABOS) | COMMON STOCK | 00509G209 | $49.5M | 20,992,669 | 0.5% |
| 4D Molecular Therapeutics in(FDMT) | COMMON STOCK | 35104E100 | $47.0M | 5,049,779 | 0.5% |
| Fulcrum Therapeutics Inc(FULC) | COMMON STOCK | 359616109 | $46.4M | 6,053,960 | 0.5% |
| Capricor Therapeutics Inc(CAPR) | COMMON STOCK | 14070B309 | $45.8M | 1,507,844 | 0.5% |
| Century Therapeutics Inc(IPSC) | COMMON STOCK | 15673T100 | $40.1M | 17,754,430 | 0.4% |
| Olema Pharmaceuticals Inc(OLMA) | COMMON STOCK | 68062P106 | $38.8M | 2,600,000 | 0.4% |
| Lenz Therapeutics Inc(LENZ) | COMMON STOCK | 52635N103 | $38.2M | 4,178,823 | 0.4% |
| Monopar Therapeutics Inc(MNPR) | COMMON STOCK | 61023L207 | $36.6M | 667,207 | 0.4% |
| Pepgen Inc(PEPG) | COMMON STOCK | 713317105 | $35.5M | 20,064,545 | 0.4% |
| Design Therapeutics Inc(DSGN) | COMMON STOCK | 25056L103 | $31.6M | 2,972,973 | 0.3% |
| Mirum Pharmaceuticals Inc(MIRM) | COMMON STOCK | 604749101 | $29.4M | 318,554 | 0.3% |
| Bioage Labs Inc(BIOA) | COMMON STOCK | 09077V100 | $28.9M | 1,650,648 | 0.3% |
| Lexeo Therapeutics Inc(LXEO) | COMMON STOCK | 52886X107 | $28.7M | 5,000,000 | 0.3% |
| Assembly Biosciences Inc(ASMB) | COMMON STOCK | 045396207 | $28.3M | 1,020,410 | 0.3% |
| Rezolute Inc(RZLT) | COMMON STOCK | 76200L309 | $28.0M | 9,180,000 | 0.3% |
| Aktis Oncology Inc(AKTS) | COMMON STOCK | 01021M104 | $26.9M | 1,503,084 | 0.3% |