Q4 2024 Holdings
Filed 2025-02-14 | 119 holdings | $2.3B | 13F-HR | View on SEC ↗ · Holdings Table ↗
Sign in to see sub-manager breakdown
| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Scholar Rock Holding Corp(SRRK) | COM | 80706P103 | $399.8M | 9,250,005 | 17.7% |
| Beigene Ltd(ONC) | SPONSORED ADR | 07725L102 | $120.7M | 653,721 | 5.3% |
| Kymera Therapeutics Inc(KYMR) | COM | 501575104 | $119.5M | 2,969,733 | 5.3% |
| Apellis Pharmaceuticals Inc(APLS) | COM | 03753U106 | $89.9M | 2,816,258 | 4.0% |
| Crinetics Pharmaceuticals Inc(CRNX) | COM | 22663K107 | $82.3M | 1,609,652 | 3.6% |
| argenx SE(ARGX) | SPONSORED ADR | 04016X101 | $70.8M | 115,045 | 3.1% |
| Bicara Therapeutics Inc(BCAX) | COM | 055477103 | $57.0M | 3,272,827 | 2.5% |
| Arrowhead Pharmaceuticals Inc(ARWR) | COM | 04280A100 | $54.6M | 2,901,681 | 2.4% |
| NewAmsterdam Pharma Company NV(NAMS) | ORDINARY SHARES | N62509109 | $53.9M | 2,095,638 | 2.4% |
| Septerna Inc(SEPN) | COM | 81734D104 | $50.4M | 2,202,514 | 2.2% |
| Centessa Pharmaceuticals PLC(CNTA) | SPONSORED ADS | 152309100 | $50.3M | 3,004,677 | 2.2% |
| SpringWorks Therapeutics Inc | COM | 85205L107 | $49.8M | 1,377,701 | 2.2% |
| Neumora Therapeutics Inc(NMRA) | COM | 640979100 | $46.6M | 4,396,100 | 2.1% |
| Wave Life Sciences Ltd(WVE) | SHS | Y95308105 | $46.4M | 3,750,491 | 2.0% |
| Ascendis Pharma A/S(ASND) | SPONSORED ADR | 04351P101 | $40.9M | 297,321 | 1.8% |
| Madrigal Pharmaceuticals Inc(MDGL) | COM | 558868105 | $38.9M | 125,942 | 1.7% |
| Taboola.com Ltd(TBLA) | ORD SHS | M8744T106 | $36.4M | 9,969,495 | 1.6% |
| Apogee Therapeutics Inc(APGE) | COM | 03770N101 | $33.9M | 747,325 | 1.5% |
| Merus NV | COM | N5749R100 | $33.0M | 784,412 | 1.5% |
| Avidity Biosciences Inc(RNA) | COM | 05370A108 | $32.8M | 1,127,295 | 1.4% |
| Vera Therapeutics Inc(VERA) | CL A | 92337R101 | $32.1M | 758,465 | 1.4% |
| Dyne Therapeutics Inc(DYN) | COM | 26818M108 | $31.7M | 1,347,456 | 1.4% |
| Xenon Pharmaceuticals Inc(XENE) | COM | 98420N105 | $29.2M | 743,769 | 1.3% |
| Lexicon Pharmaceuticals Inc(LXRX) | COM NEW | 528872302 | $28.8M | 38,918,903 | 1.3% |
| Bicycle Therapeutics PLC(BCYC) | SPONSORED ADS | 088786108 | $25.8M | 1,839,398 | 1.1% |
| Revolution Medicines Inc(RVMD) | COM | 76155X100 | $25.0M | 571,548 | 1.1% |
| Vaxcyte Inc(PCVX) | COM | 92243G108 | $24.6M | 299,991 | 1.1% |
| Arcus Biosciences Inc(RCUS) | COM | 03969F109 | $24.0M | 1,612,077 | 1.1% |
| Erasca Inc(ERAS) | COM | 29479A108 | $22.2M | 8,857,179 | 1.0% |
| Stoke Therapeutics Inc(STOK) | COM | 86150R107 | $22.1M | 2,000,000 | 1.0% |
| IGM Biosciences Inc(1K0) | COM | 449585108 | $20.3M | 3,330,422 | 0.9% |
| Edgewise Therapeutics Inc(EWTX) | COM | 28036F105 | $19.6M | 734,343 | 0.9% |
| Silence Therapeutics PLC(SLN) | ADS | 82686Q101 | $19.5M | 2,831,770 | 0.9% |
| Cytokinetics Inc(CYTK) | COM NEW | 23282W605 | $18.9M | 402,323 | 0.8% |
| Denali Therapeutics Inc(DNLI) | COM | 24823R105 | $17.0M | 834,028 | 0.8% |
| Korro Bio Inc(KRRO) | COM | 500946108 | $15.9M | 418,833 | 0.7% |
| Soleno Therapeutics Inc(SLNO) | COM | 834203309 | $15.8M | 351,818 | 0.7% |
| Prothena Corporation PLC(PRTA) | SHS | G72800108 | $15.2M | 1,099,840 | 0.7% |
| Solid Biosciences Inc(SLDB) | COM NEW | 83422E204 | $15.0M | 3,749,041 | 0.7% |
| Cullinan Therapeutics Inc(CGEM) | COM | 230031106 | $14.8M | 1,211,357 | 0.7% |
| Upstream Bio Inc(UPB) | COM | 91678A107 | $13.2M | 800,000 | 0.6% |
| Trevi Therapeutics Inc(TRVI) | COM | 89532M101 | $12.0M | 2,906,060 | 0.5% |
| Kura Oncology Inc(KURA) | COM | 50127T109 | $11.7M | 1,339,942 | 0.5% |
| Taysha Gene Therapies Inc(TSHA) | COM SHS | 877619106 | $11.4M | 6,602,475 | 0.5% |
| Remitly Global Inc(RELY) | COM | 75960P104 | $11.1M | 490,449 | 0.5% |
| Cartesian Therapeutics Inc(RNAC) | COM NEW | 816212302 | $10.2M | 572,236 | 0.5% |
| Microsoft Corp(MSFT) | COM | 594918104 | $9.7M | 23,000 | 0.4% |
| Janux Therapeutics Inc(JANX) | COM | 47103J105 | $9.4M | 175,000 | 0.4% |
| Seer Inc(SEER) | COM CL A | 81578P106 | $9.2M | 4,000,000 | 0.4% |
| Ionis Pharmaceuticals Inc(IONS) | COM | 462222100 | $8.7M | 250,000 | 0.4% |