Q3 2025 Holdings
Filed 2025-11-13 | 117 holdings | $2.6B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Scholar Rock Holding Corp(SRRK) | COM | 80706P103 | $344.5M | 9,250,005 | 13.5% |
| Kymera Therapeutics Inc(KYMR) | COM | 501575104 | $194.0M | 3,428,150 | 7.6% |
| BeOne Medicines AG(ONC) | SPONSORED ADS | 07725L102 | $168.0M | 492,990 | 6.6% |
| Arrowhead Pharmaceuticals Inc(ARWR) | COM | 04280A100 | $92.1M | 2,669,880 | 3.6% |
| Bicara Therapeutics Inc(BCAX) | COM | 055477103 | $82.4M | 5,216,969 | 3.2% |
| Centessa Pharmaceuticals PLC(CNTA) | SPONSORED ADS | 152309100 | $78.3M | 3,227,517 | 3.1% |
| Crinetics Pharmaceuticals Inc(CRNX) | COM | 22663K107 | $70.3M | 1,688,611 | 2.8% |
| Edgewise Therapeutics Inc(EWTX) | COM | 28036F105 | $63.2M | 3,897,099 | 2.5% |
| Disc Medicine Inc(IRON) | COM | 254604101 | $60.4M | 913,401 | 2.4% |
| Dyne Therapeutics Inc(DYN) | COM | 26818M108 | $59.8M | 4,729,174 | 2.3% |
| Apellis Pharmaceuticals Inc(APLS) | COM | 03753U106 | $58.3M | 2,578,396 | 2.3% |
| Avidity Biosciences Inc(RNA) | COM | 05370A108 | $56.0M | 1,285,610 | 2.2% |
| Stoke Therapeutics Inc(STOK) | COM | 86150R107 | $52.8M | 2,247,347 | 2.1% |
| Lexicon Pharmaceuticals Inc(LXRX) | COM NEW | 528872302 | $52.5M | 38,918,903 | 2.1% |
| Rhythm Pharmaceuticals Inc(RYTM) | COM | 76243J105 | $50.5M | 499,975 | 2.0% |
| Tango Therapeutics Inc(TNGX) | COM | 87583X109 | $49.4M | 5,883,188 | 1.9% |
| Revolution Medicines Inc(RVMD) | COM | 76155X100 | $48.7M | 1,043,720 | 1.9% |
| Ascendis Pharma A/S(ASND) | SPONSORED ADR | 04351P101 | $46.9M | 235,862 | 1.8% |
| Rezolute Inc(RZLT) | COM NEW | 76200L309 | $45.8M | 4,870,000 | 1.8% |
| Solid Biosciences Inc(SLDB) | COM NEW | 83422E204 | $45.8M | 7,415,905 | 1.8% |
| Septerna Inc(SEPN) | COM | 81734D104 | $41.4M | 2,202,514 | 1.6% |
| Arcus Biosciences Inc(RCUS) | COM | 03969F109 | $39.6M | 2,912,077 | 1.5% |
| Taysha Gene Therapies Inc(TSHA) | COM SHS | 877619106 | $36.0M | 11,014,737 | 1.4% |
| Taboola.com Ltd(TBLA) | ORD SHS | M8744T106 | $34.0M | 9,969,495 | 1.3% |
| Xenon Pharmaceuticals Inc(XENE) | COM | 98420N105 | $32.6M | 812,761 | 1.3% |
| Soleno Therapeutics Inc(SLNO) | COM | 834203309 | $31.6M | 467,342 | 1.2% |
| Rapport Therapeutics Inc(RAPP) | COM | 75383L102 | $31.3M | 1,053,469 | 1.2% |
| Structure Therapeutics Inc(GPCR) | SPONSORED ADS | 86366E106 | $28.8M | 1,026,811 | 1.1% |
| Wave Life Sciences Ltd(WVE) | SHS | Y95308105 | $27.1M | 3,696,322 | 1.1% |
| Remitly Global Inc(RELY) | COM | 75960P104 | $26.4M | 1,618,271 | 1.0% |
| Cogent Biosciences Inc(COGT) | COM | 19240Q201 | $24.8M | 1,724,279 | 1.0% |
| Trevi Therapeutics Inc(TRVI) | COM | 89532M101 | $23.2M | 2,536,867 | 0.9% |
| NewAmsterdam Pharma Company NV(NAMS) | ORDINARY SHARES | N62509109 | $21.8M | 765,705 | 0.9% |
| Korro Bio Inc(KRRO) | COM | 500946108 | $20.1M | 418,833 | 0.8% |
| Erasca Inc(ERAS) | COM | 29479A108 | $19.1M | 8,757,249 | 0.7% |
| IHS Holding Limited(IHS) | ORD SHS | G4701H109 | $16.1M | 2,357,520 | 0.6% |
| Uniqure NV(QURE) | SHS | N90064101 | $16.1M | 275,200 | 0.6% |
| Bicycle Therapeutics PLC(BCYC) | SPONSORED ADS | 088786108 | $15.6M | 2,012,752 | 0.6% |
| Silence Therapeutics PLC(SLN) | ADS | 82686Q101 | $15.1M | 2,911,438 | 0.6% |
| Rapt Therapeutics Inc(RAPT) | COM NEW | 75382E208 | $15.0M | 580,466 | 0.6% |
| Upstream Bio Inc(UPB) | COM | 91678A107 | $14.8M | 788,450 | 0.6% |
| Gossamer Bio Inc(GOSS) | COM | 38341P102 | $13.7M | 5,208,968 | 0.5% |
| Arrivent Biopharma Inc(AVBP) | COM | 04272N102 | $12.9M | 700,000 | 0.5% |
| Amazon.com Inc(AMZN) | COM | 023135106 | $12.8M | 58,500 | 0.5% |
| Oric Pharmaceuticals Inc(ORIC) | COM | 68622P109 | $12.1M | 1,007,575 | 0.5% |
| Denali Therapeutics Inc(DNLI) | COM | 24823R105 | $11.9M | 821,513 | 0.5% |
| Ionq Inc(IONQ) | COM | 46222L108 | $10.5M | 170,000 | 0.4% |
| Sionna Therapeutics Inc(SION) | COM | 829401108 | $9.6M | 325,000 | 0.4% |
| CrowdStrike Holdings Inc(CRWD) | CL A | 22788C105 | $9.1M | 18,500 | 0.4% |
| Microsoft Corp(MSFT) | COM | 594918104 | $8.9M | 17,150 | 0.3% |