Q4 2025 Holdings
Filed 2026-02-13 | 115 holdings | $3.4B | 13F-HR | View on SEC ↗ · Holdings Table ↗
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| Issuer | Class | CUSIP | Value ↓ | Shares | % Portfolio |
|---|---|---|---|---|---|
| Scholar Rock Holding Corp(SRRK) | COM | 80706P103 | $476.8M | 10,825,013 | 14.2% |
| Kymera Therapeutics Inc(KYMR) | COM | 501575104 | $255.7M | 3,286,830 | 7.6% |
| BeOne Medicines AG(ONC) | SPONSORED ADS | 07725L102 | $151.9M | 500,000 | 4.5% |
| Edgewise Therapeutics Inc(EWTX) | COM | 28036F105 | $112.4M | 4,529,990 | 3.4% |
| Revolution Medicines Inc(RVMD) | COM | 76155X100 | $106.3M | 1,335,075 | 3.2% |
| Centessa Pharmaceuticals PLC(CNTA) | SPONSORED ADS | 152309100 | $100.7M | 4,027,517 | 3.0% |
| Arrowhead Pharmaceuticals Inc(ARWR) | COM | 04280A100 | $99.6M | 1,500,476 | 3.0% |
| Bicara Therapeutics Inc(BCAX) | COM | 055477103 | $87.8M | 5,216,969 | 2.6% |
| Olema Pharmaceuticals Inc(OLMA) | COM | 68062P106 | $82.5M | 3,300,700 | 2.5% |
| Disc Medicine Inc(IRON) | COM | 254604101 | $78.5M | 988,401 | 2.3% |
| Structure Therapeutics Inc(GPCR) | SPONSORED ADS | 86366E106 | $75.0M | 1,078,698 | 2.2% |
| Tango Therapeutics Inc(TNGX) | COM | 87583X109 | $72.3M | 8,165,374 | 2.2% |
| Arcus Biosciences Inc(RCUS) | COM | 03969F109 | $71.7M | 3,007,077 | 2.1% |
| Stoke Therapeutics Inc(STOK) | COM | 86150R107 | $71.3M | 2,247,347 | 2.1% |
| Crinetics Pharmaceuticals Inc(CRNX) | COM | 22663K107 | $70.2M | 1,507,636 | 2.1% |
| Dyne Therapeutics Inc(DYN) | COM | 26818M108 | $68.5M | 3,502,941 | 2.0% |
| Apellis Pharmaceuticals Inc(APLS) | COM | 03753U106 | $64.8M | 2,578,396 | 1.9% |
| Cogent Biosciences Inc(COGT) | COM | 19240Q201 | $57.9M | 1,629,279 | 1.7% |
| Septerna Inc(SEPN) | COM | 81734D104 | $55.8M | 2,000,000 | 1.7% |
| Taysha Gene Therapies Inc(TSHA) | COM SHS | 877619106 | $55.7M | 10,129,913 | 1.7% |
| Rhythm Pharmaceuticals Inc(RYTM) | COM | 76243J105 | $53.5M | 499,975 | 1.6% |
| Ascendis Pharma A/S(ASND) | SPONSORED ADR | 04351P101 | $50.3M | 235,862 | 1.5% |
| Rapt Therapeutics Inc(RAPT) | COM NEW | 75382E208 | $46.6M | 1,375,000 | 1.4% |
| Taboola.com Ltd(TBLA) | ORD SHS | M8744T106 | $46.0M | 9,969,495 | 1.4% |
| Lexicon Pharmaceuticals Inc(LXRX) | COM NEW | 528872302 | $44.8M | 38,918,903 | 1.3% |
| Zymeworks Inc(ZYME) | COM | 98985Y108 | $44.2M | 1,680,121 | 1.3% |
| Solid Biosciences Inc(SLDB) | COM NEW | 83422E204 | $43.4M | 7,690,405 | 1.3% |
| Wave Life Sciences Ltd(WVE) | SHS | Y95308105 | $41.7M | 2,450,000 | 1.2% |
| Xenon Pharmaceuticals Inc(XENE) | COM | 98420N105 | $36.4M | 812,761 | 1.1% |
| Dbv Technologies SA(DBVT) | SPONSORED ADS | 23306J309 | $35.6M | 1,857,362 | 1.1% |
| Erasca Inc(ERAS) | COM | 29479A108 | $32.6M | 8,757,249 | 1.0% |
| enGene Holdings Inc(ENGN) | COM | 29286M105 | $30.1M | 3,336,264 | 0.9% |
| Trevi Therapeutics Inc(TRVI) | COM | 89532M101 | $28.6M | 2,286,867 | 0.9% |
| Spyre Therapeutics Inc(SYRE) | COM NEW | 00773J202 | $26.8M | 818,598 | 0.8% |
| Mineralys Therapeutics Inc(MLYS) | COM | 603170101 | $25.4M | 699,999 | 0.8% |
| Denali Therapeutics Inc(DNLI) | COM | 24823R105 | $23.1M | 1,396,513 | 0.7% |
| Remitly Global Inc(RELY) | COM | 75960P104 | $22.3M | 1,618,271 | 0.7% |
| Fulcrum Therapeutics Inc(FULC) | COM | 359616109 | $22.1M | 1,950,000 | 0.7% |
| Rapport Therapeutics Inc(RAPP) | COM | 75383L102 | $21.5M | 708,469 | 0.6% |
| Silence Therapeutics PLC(SLN) | ADS | 82686Q101 | $17.7M | 2,911,438 | 0.5% |
| IHS Holding Limited(IHS) | ORD SHS | G4701H109 | $17.6M | 2,357,520 | 0.5% |
| Gossamer Bio Inc(GOSS) | COM | 38341P102 | $16.1M | 5,208,968 | 0.5% |
| Upstream Bio Inc(UPB) | COM | 91678A107 | $16.0M | 588,450 | 0.5% |
| Bicycle Therapeutics PLC(BCYC) | SPONSORED ADS | 088786108 | $14.3M | 2,012,752 | 0.4% |
| Monopar Therapeutics Inc(MNPR) | COM NEW | 61023L207 | $13.9M | 212,298 | 0.4% |
| Cullinan Therapeutics Inc(CGEM) | COM | 230031106 | $12.4M | 1,193,410 | 0.4% |
| Sionna Therapeutics Inc(SION) | COM | 829401108 | $12.3M | 300,000 | 0.4% |
| Inhibikase Therapeutics Inc(IKT) | COM NEW | 45719W205 | $12.0M | 5,850,000 | 0.4% |
| NovaBridge Biosciences(NBP) | SPONSORED ADS | 44975P103 | $11.9M | 3,000,000 | 0.4% |
| Amazon.com Inc(AMZN) | COM | 023135106 | $11.9M | 51,500 | 0.4% |